Abstract: The invention relates to determining a model of a cardiac implant deployed in a cardiac region of a patient. A database including a plurality of different records is provided, each record including at least data representative of an image of a cardiac region and an associated model of the cardiac implant deployed in said cardiac region. A patient-specific image of the cardiac region for which the model of the cardiac implant deployed in said cardiac region is to be determined, is received. An approximation of the patient-specific image of the cardiac region is calculated based on a weighted combination of images of the cardiac region in a plurality of records. The model of the cardiac implant deployed in the cardiac region associated to the patient-specific image of said cardiac region is determined based on weighted combination of models of the cardiac implant associated to the images of the cardiac region in the plurality of records used for approximating said patient-specific image of the cardiac region.

Abstract: A mop holder, in cases a flat mop holder, having an upper side and an opposite lower side, which faces or can face, in cases, an inner side of a mop cover, comprises, in a region of the upper side, a connecting piece which is adapted and arranged to receive a mop handle and to connect the mop handle to the mop holder. The connecting piece comprises a pivot-tilt joint which is adapted and arranged to permit a movability of the mop holder relative to the mop handle about an axis of rotation and about a tilt axis. The pivot-tilt joint comprises an elastic pretensioning device which is adapted and arranged to urge the mop holder with respect to the tilt axis and with respect to the axis of rotation into a predetermined, in cases central, starting position.

Abstract: The disclosure relates to a valve, comprising a main plunger for controlling a main volume flow and comprising a pilot-control plunger for controlling a pilot-control volume flow. The main and pilot-control plungers are longitudinally moveably guided in a valve housing and the pilot-control plunger can be actuated by a magnetic device. The position of the main plunger can be adjusted by the pilot-control plunger in that a fluid pressure at the main plunger is communicated, via a fluid connection, into the pilot control chamber containing the pilot-control piston, which keeps the main plunger in its closed position blocking the main volume flow when the magnetic device is not actuated. When the magnetic device is actuated, the pilot-control plunger moves into a position in which the fluid pressure falls in the pilot-control chamber until the main plunger moves into an open position controlling the main volume flow.

Abstract: Devices, systems, and methods for managing chassis of data processing systems are disclosed. The chassis may be managed by reversibly attaching them to structural members such as rails. When so attached, the chassis may be fixedly held in a position. To facilitate access to an interior of the chassis, the chassis may be detached from the structural member and moved to a maintenance position. To detach the chassis from the structural member, the chassis may include a latch. The latch may be positioned in an ear of the chassis and may be protected by a frame. The frame may include a recess, hole, or other feature to facilitate access to the latch. The access may allow application of force to a single portion of the latch to rotate or otherwise actuate the latch. Actuation of the latch may facilitate detachment of the chassis from the structural member.

Abstract: The present disclosure includes MGMT modifications that cause MGMT resistance to MGMT inhibitors. The present disclosure also includes in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids to encode and express an MGMT variant that is resistant to MGMT inhibitors. Inhibitor-resistant MGMT modifications and modification of an MGMT-encoding nucleic can occur or be used in conjunction with a therapeutic modification, e.g., in a single cell. Expression of inhibitor-resistant MGMT can selectively protect modified cells from a selection regimen, such as a selection regimen including an MGMT inhibitor and an alkylating agent. Accordingly, in vivo, in vitro, and ex vivo modification of MGMT-encoding nucleic acids can be used in gene therapy to select for modified cells.

Abstract: The invention concerns a sensor arrangement (9) for an apparatus (1) for the additive manufacture of a component (2) in a manufacturing process in which build material (13), preferably comprising a metal powder, is consolidated on a construction area (8) in a processing area (3) by means of irradiation of the build material (13) with at least one energy beam (AL), the sensor arrangement (9) comprising: a sensor module (90) which is configured to detect oxygen molecules in a gas sample (P) permeating into the sensor module (90) and to generate an electrical sensor signal (S) based on the quantity of the oxygen molecules, a selective filter element (F) configured to filter the gas sample (P) so that at least hydrogen molecules and/or hydrogen ions and/or water molecules and/or hydroxide ions are filtered out of the gas sample (P). The invention further concerns a manufacturing apparatus as well as a measurement method with such a sensor arrangement.

Abstract: Described is a pallet including a base having a length extending between a first end and a second end opposite the first end and a width transverse to the length; and a cage removably coupled to the base.

Abstract: In one embodiment, a computer-implemented system includes treatment apparatuses configured to be manipulated by patients while performing an exercise session, patient interfaces associated with the plurality of patients, and a server computing device configured to receive first characteristics pertaining to the patients, and initiate a virtual shared session on the patient interfaces associated with the patients. The virtual shared session includes at least a set of multimedia feeds, and each multimedia feed of the set of multimedia feeds is associated with one or more of the patients. During the virtual shared session, the server computing device may present a first layout including the set of multimedia feeds, the first characteristics, or some combination thereof.

Abstract: The present application relates to a system comprising a hearing aid, the hearing aid configured to be operated based on an estimation of a current listening effort of a hearing aid user.

Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: A cylinder/reciprocating-piston device for a compressed air engine includes a hollow cylinder having a hollow-cylinder wall defining a pressure space, a piston that is movable the pressure space, and valves that respectively open/close valve flow channels in the hollow-cylinder wall. The hollow-cylinder has a surface that delimits the pressure space in a radial direction, a ceiling wall that axially upwardly delimits the pressure space, a floor wall that axially downwardly delimits the pressure space, and a piston-rod opening in the floor- and/or ceiling wall that slidably guide(s) a piston rod. The piston divides the pressure space into a first pressure chamber between the piston and the ceiling wall, and a second pressure chamber between the piston and the floor wall. A minimum flow-cross section of one or more of the valve flow channels is preferably at least 10% of the effective cross-sectional surface area of the piston.

Abstract: The present application describes systems and methods for network-based blocking threat intelligence. An access control list (ACL) generator may modify ACLs and provide modified ACLs to provider edge routers based on the capabilities of the provider edge routers. In some cases, an additional provider edge router that is more capable of implementing longer ACLs may be used. In some cases, a collector may identify when threat communications are bypassing provider edge routers with limited ACL lengths and provide the customer an opportunity to buy a better router or access to an additional router that supports longer or additional ACLs. A threat intelligence system may update (e.g., continuously update) the ACL provided to the ACL generator, and the ACL generator may accordingly update the modified ACLs provided to the provider edge routers.

Abstract: A harvesting program system iteratively generates current harvesting programs for performance by harvesting equipment on a mushroom bed. The system receives current mushroom bed data corresponding to the mushroom bed including growing mushrooms at the current times. The system processes the current mushroom bed data using a mushroom bed model to generate current virtual mushroom beds corresponding to current states of the mushroom bed at the current times. The mushroom bed model is trained using labelled training mushroom bed data including known values of the mushroom bed, and using previously-generated virtual mushroom beds corresponding to predicted states of the mushroom bed. The system generates using the mushroom bed model predicted virtual mushroom beds corresponding to predicted states of the mushroom bed at future times. The system generates current harvesting programs based on the predicted virtual mushroom beds, and transmits them performance by the harvesting equipment on the mushroom bed.

Abstract: Embodiments described herein may be directed to systems, methods, apparatuses, devices, computer program products, computer-executable instructions, and/or applications for providing a remote cloud browsing session. A remote cloud browsing session may receive a request for Internet content from a user device, access the Internet content from an Internet content source, and transmit second Internet content to the user device based on the requested Internet content.

Abstract: The disclosure relates to a support structure of a passenger transport system which is designed an escalator or moving walkway and comprises an alignment device for two support structure sections of the support structure to be connected to one another. The alignment device comprises a first alignment part comprising a fastening region and a recess, and a second alignment part comprising a fastening region and a projection, wherein a contour of the projection is complementary to a contour of the recess. The projection and/or the recess also have a V-shape.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein.

Abstract: The invention relates to a rotary machine comprising a stator and a rotatably mounted rotor, with one or more magnetic field sensors arranged stationary relative to the stator at a radial distance from a stationary axis, at least one measuring device which is configured to detect magnetic field changes with the aid of the aforementioned magnetic field sensors, a rotor which is configured to generate one or more electrical signals in each case, said signals having signal components which correspond to the rotor rotation frequency and to the distance between magnetic field sensor and rotor in each case, wherein a demodulator unit carries out a demodulation of signals generated by or derived from the magnetic field sensors, such that a signal is generated which corresponds to the distance between the rotor and the magnetic field sensor.

Abstract: A cooling element for a furnace includes a first side configured to be directed towards the inside of the furnace, a second side opposite to the first side and configured to be directed away from the inside of the furnace, and a cooling fluid channel system for cooling fluid circulation. The cooling element further includes a monitoring channel system including at least one monitoring channel for pressure medium. At least a portion of the monitoring channel extends in a portion of the cooling element provided between the first side and a plane defined by the points of the cooling fluid channel system closest to the first side.

Abstract: Disclosed herein, in aspects, are compositions, methods, kits, and systems relating to efficient delivery of freights (e.g., therapeutic freights) into cells, for instance, for in vivo delivery.

Abstract: A combination cooking appliance has a cooking chamber and a microwave source with a microwave power. In a method for the safe operation of the combination cooking appliance, a cooking chamber temperature prevailing in the cooking chamber is detected, and a convection-relevant parameter is determined. The detected cooking chamber temperature and the convection-relevant parameter are evaluated to determine a maximum permissible microwave power. The microwave power of the microwave source is limited to the maximum permissible microwave power.