Abstract: A radiotherapy delivery device is provided. The device includes a source of therapeutic radiation and a first detector positioned to receive radiation from the source of therapeutic radiation. The device also includes a source of imaging radiation and a second detector positioned to receive radiation from the source of imaging radiation. A collimator assembly is positioned relative to the second source of radiation to selectively control a shape of a radiation beam emitted by the second radiation source to selectively expose part or the whole of the second radiation detector. A reconstruction processor can be operatively coupled to the detector and configured to generate patient images based on radiation received by the second detector from the second source of radiation. The device is configured to move from one imaging geometry to another using all or part of the second detector.

Abstract: A processing device determines a plurality of angles from which tracking images can be generated by an imaging device. The processing device generates a plurality of projections of a treatment planning image of a patient, the treatment planning image comprising a delineated target, wherein each projection of the plurality of projections has an angle that corresponds to one of the plurality of angles from which the tracking images can be taken. The processing device determines, for each angle of the plurality of angles, a value of a tracking quality metric for tracking the target based on an analysis of a projection generated at that angle. The processing device selects a subset of the plurality of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion.

Abstract: Systems and methods for tracking a target volume, e.g., tumor, during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions to cause the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.

Abstract: A method of image-guided radiation treatment is described. The method may include acquiring digitally reconstructed radiographs (DRRs) of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level. The method may also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target. The method may also include registering the enhanced image with the DRRs to obtain a registration result, tracking movement and position of the target using the registration result to generating tracking information.

Abstract: A method is described, including acquiring, using a camera, an image of a radiation beam incident on a phantom, the radiation beam being emitted by a radiation source. The method further includes determining a beam pointing offset based on the image and calibrating a position of the radiation source based on the beam pointing offset. A calibration system is described including the phantom, the camera, and a processing device. A phantom having an X-ray luminescent material is also described.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: A method of generating an image synthesis process is disclosed, where the image synthesis process improves image quality of degraded volumetric images. In the method, a machine learning process is trained in a supervised learning framework as the image synthesis process. In the supervised learning process, a lower-quality partial-data reconstruction of a target volume is employed as an input object in the supervised learning process and a higher-quality full data reconstruction of the target volume is employed as an expected output. The full data reconstruction is generated based on a first set of projection images of the three-dimensional volume and the partial-data reconstruction is generated based on a second set of projection images of the three-dimensional volume, where the second set of projection images includes projection images that have less image information and/or are of a lower image quality than the first set of projection images.

Abstract: A processing device determines a plurality of angles from which tracking images can be generated by an imaging device. The processing device generates a plurality of projections of a treatment planning image of a patient, the treatment planning image comprising a delineated target, wherein each projection of the plurality of projections has an angle that corresponds to one of the plurality of angles from which the tracking images can be taken. The processing device determines, for each angle of the plurality of angles, a value of a tracking quality metric for tracking the target based on an analysis of a projection generated at that angle. The processing device selects a subset of the plurality of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion.

Abstract: A method of image-guided radiation treatment is described. The method may include acquiring digitally reconstructed radiographs (DRRs) of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level, wherein the first energy level is an energy level selected within the range of 50-100 kV and the second energy level is an energy level selected within the range of 100-150 kV. The method ma also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: A method including imaging a first field of view (FOV) of a volume of interest (VOI) that includes a region of interest (ROI) from a first position and imaging the first FOV of the VOI from a second position. The method including receiving a first identification of a first portion of the imaged VOI designating the ROI to be imaged and a second identification of a second portion of the imaged VOI from the second position designating the ROI to be imaged. In response to the first identification, adjusting an aperture of a collimator of an imaging source to a second FOV corresponding to the ROI from the first position and imaging the ROI using the second FOV. In response to the second identification, adjusting the aperture of the collimator to a third FOV corresponding to the ROI from the second position and imaging the ROI using the third FOV.

Abstract: A reference image of a patient may be generated. A subsequent x-ray image of the patient may be generated after the generating of the reference image where the subsequent x-ray image is associated with a low dosage. A difference between the reference image and the subsequent x-ray image that is associated with the low dosage may be determined. A motion of the patient may be identified as having occurred based on the determined difference.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: Methods of two-dimensional x-ray imaging of a target volume and tracking a target structure contained within a target volume are described.

Abstract: Images that are associated with an identification of a tracking target of a patient to receive radiation treatment may be received. The images may be sorted into a sequence based on a motion of the patient. The sorted images may be provided via a graphical user interface. The sequence of the sorted images that are based on the motion of the patient may be provided.

Abstract: A method is described, including acquiring, using a camera, an image of a radiation beam incident on a phantom, the radiation beam being emitted by a radiation source. The method further includes determining a beam pointing offset based on the image and calibrating a position of the radiation source based on the beam pointing offset. A calibration system is described including the phantom, the camera, and a processing device. A phantom having an X-ray luminescent material is also described.

Abstract: A phantom is described. The phantom having a spherical phantom body and an X-ray luminescent material, wherein at least a portion of the X-ray luminescent material is on a surface of the phantom.

Abstract: A method of sequential monoscopic tracking is described. The method includes generating a plurality of projections of an internal target region within a body of a patient, the plurality of projections comprising projection data about a position of an internal target region of the patient. The method further includes generating external positional data about external motion of the body of the patient using one or more external sensors. The method further includes generating, by a processing device, a correlation model between the projection data and the external positional data by fitting the plurality of projections of the internal target region to the external positional data. The method further includes estimating the position of the internal target region at a later time using the correlation model.

Abstract: Images that are associated with an identification of a tracking target of a patient to receive radiation treatment may be received. The images may be sorted into a sequence based on a motion of the patient. The sorted images may be provided via a graphical user interface. The sequence of the sorted images that are based on the motion of the patient may be provided.