Abstract: A method includes determining a first set of positions for a volumetric imager and determining a second set of positions for a linear accelerator (LINAC), during radiation treatment delivery. The method further includes determining a set of radiation beam directionalities of the LINAC, wherein for each of the second set of positions for the LINAC a radiation beam corresponds to a radiation beam directionality. The method further includes generating instructions for the volumetric imager based on the first and the second set of positions, the radiation beam directionalities, and a treatment time constraint to avoid a collision between the volumetric imager and the LINAC and between the volumetric imager and the radiation beam, wherein the instructions include physical locations of the volumetric imager and timing values corresponding to the physical locations. The method further includes operating the volumetric imager during the radiation treatment delivery according to the set of instructions.

Abstract: A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

Abstract: A method of the present disclosure includes identifying, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV). The method further includes determining, based on a motion image, a partial motion range of the target, wherein the partial motion range is an untracked portion of the full motion range of the target comprising one of an untracked plane or an untracked axis. The method further includes generating, by a processing device, a partial ITV based on the partial range of motion of the target, wherein the partial ITV is a volume swept by the target as the target moves through the partial motion range, and wherein the partial ITV is smaller than the full ITV. The method further includes providing the partial ITV to assist in tracking the target.

Abstract: A method includes determining a first estimate of leaf positions for a plurality of leaves of a multi-leaf collimator (MLC) in a reference coordinate space based on an image generated by an image-based aperture verification system, wherein the leaf positions for the plurality of leaves define an aperture for the MLC. The method further includes determining a second estimate of the leaf positions for the plurality of leaves in the reference coordinate space based on data from an additional source. The method further includes verifying the leaf positions for the plurality of leaves based on comparing the first estimate to the second estimate, wherein the leaf positions are verified if the first estimate deviates from the second estimate by less than a threshold value.

Abstract: A method includes receiving, from a volumetric imager, a first image including a target of a patient. The method further includes receiving a second image including the target of the patient. The method further includes tracking, by a processing device, a position of the target using the first image and the second image.

Abstract: A method of the present disclosure includes identifying, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV). The method further includes identifying a non-target object in a motion image or the reference image. The method further includes performing a volumetric alignment of the ITV and the non-target object. The method further includes modifying a non-target to target displacement vector based on the volumetric alignment. The method further includes tracking the target based on the modified non-target to target displacement vector.

Abstract: A radiation delivery system includes a multi-leaf collimator (MLC) that includes a housing, a plurality of leaves disposed within the housing, and an image sensor disposed within the housing at a position that is offset from a beam axis. The plurality of leaves are movable to define an aperture for the MLC, and the image sensor is directed toward the plurality of leaves. The image sensor is to generate an oblique-view image of the aperture. The radiation delivery system additionally includes a processing device to receive the oblique-view image, transform the oblique-view image into a top-view image having a reference coordinate space, and determine whether the aperture for the MLC corresponds to a specified aperture based on the top-view image.

Abstract: Tracking a target structure contained within a target volume using an x-ray tomosynthesis imaging detector is described.

Abstract: A method includes determining a first estimate of leaf positions for a plurality of leaves of a multi-leaf collimator (MLC) in a reference coordinate space based on an image generated by an image-based aperture verification system, wherein the leaf positions for the plurality of leaves define an aperture for the MLC. The method further includes determining a second estimate of the leaf positions for the plurality of leaves in the reference coordinate space based on data from an additional source. The method further includes verifying the leaf positions for the plurality of leaves based on comparing the first estimate to the second estimate, wherein the leaf positions are verified if the first estimate deviates from the second estimate by less than a threshold value.

Abstract: A radiation therapy apparatus determines a set of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion. During an alignment phase or a treatment phase for a treatment stage of a target by the radiation therapy apparatus, the radiation therapy apparatus performs selects at least a first angle and a second angle from the set of angles for a first rotation of the gantry. The radiation therapy apparatus generates, using an imaging device mounted to the gantry, a first tracking image of the target from the first angle during the first rotation of the gantry. The radiation therapy apparatus generates, using the imaging device, a second tracking image of the target from the second angle during the first rotation of the gantry. The radiation therapy apparatus performs the target tracking based on the first tracking image and the second tracking image.

Abstract: A processing device determines a plurality of angles from which tracking images can be generated by an imaging device. The processing device generates a plurality of projections of a treatment planning image of a patient, the treatment planning image comprising a delineated target, wherein each projection of the plurality of projections has an angle that corresponds to one of the plurality of angles from which the tracking images can be taken. The processing device determines, for each angle of the plurality of angles, a value of a tracking quality metric for tracking the target based on an analysis of a projection generated at that angle. The processing device selects a subset of the plurality of angles that have a tracking quality metric value that satisfies a tracking quality metric criterion.

Abstract: An IGRT system and methods are described embodiments of which perform selectively integration of x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and source collimation, or inverse geometry tomosynthesis imaging to acquire or track a target during radiation treatment.

Abstract: Tracking a target structure contained within a target volume using an x-ray tomosynthesis imaging detector is described.

Abstract: Methods of two-dimensional x-ray imaging of a target volume and tracking a target structure contained within a target volume are described.

Abstract: A method of ambient light suppression in an imaging system, including illuminating leaves of a multi-leaf collimator (MLC) with a first light of a lighting system inside a housing of the MCL, receiving ambient light inside the housing of the MLC through an aperture of the MLC, and capturing, using an imaging system having optics situated inside the housing of the MLC, an image of the leaves of the MLC illuminated with the first light and the ambient light. The method may further include, suppressing the ambient light in the first image to generate a second image of the leaves of the MLC and detecting a feature of the leaves of the MLC in the second image.

Abstract: Images that are associated with an identification of a tracking target of a patient to receive radiation treatment may be received. The images may be sorted into a sequence based on a motion of the patient. The sorted images may be provided via a graphical user interface. The sequence of the sorted images that are based on the motion of the patient may be provided.

Abstract: A radiation delivery system includes a multi-leaf collimator (MLC) that includes a housing, a plurality of leaves disposed within the housing, and an image sensor disposed within the housing at a position that is offset from a beam axis. The plurality of leaves are movable to define an aperture for the MLC, and the image sensor is directed toward the plurality of leaves. The image sensor is to generate an oblique-view image of the aperture. The radiation delivery system additionally includes a processing device to receive the oblique-view image, transform the oblique-view image into a top-view image having a reference coordinate space, and determine whether the aperture for the MLC corresponds to a specified aperture based on the top-view image.

Abstract: A method of ambient light suppression in an imaging system, including illuminating leaves of a multi-leaf collimator (MLC) with a first light of a lighting system inside a housing of the MCL, receiving ambient light inside the housing of the MLC through an aperture of the MLC, and capturing, using an imaging system having optics situated inside the housing of the MLC, an image of the leaves of the MLC illuminated with the first light and the ambient light. The method may further include, suppressing the ambient light in the first image to generate a second image of the leaves of the MLC and detecting a feature of the leaves of the MLC in the second image.

Abstract: A method includes determining a first estimate of leaf positions for a plurality of leaves of a multi-leaf collimator (MLC) in a reference coordinate space based on an image generated by an image-based aperture verification system, wherein the leaf positions for the plurality of leaves define an aperture for the MLC. The method further includes determining a second estimate of the leaf positions for the plurality of leaves in the reference coordinate space based on data from an additional source. The method further includes verifying the leaf positions for the plurality of leaves based on comparing the first estimate to the second estimate, wherein the leaf positions are verified if the first estimate deviates from the second estimate by less than a threshold value.

Abstract: A method of image-guided radiation treatment is described. The method may include acquiring digitally reconstructed radiographs (DRRs) of a patient and generating a first set of image data of part or all of the patient using imaging radiation at a first energy level and a second set of image data of part or all of the patient using imaging radiation at a second energy level, wherein the first energy level is an energy level selected within the range of 50-100 kV and the second energy level is an energy level selected within the range of 100-150 kV. The method ma also include processing the first and second sets of image data to generate an enhanced image, wherein the enhanced image comprises a combination of the first and second sets of image data, and wherein part or all of the image data comprises the target.