Patents by Inventor Philip A. Lessard
Philip A. Lessard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12116584Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: GrantFiled: May 20, 2022Date of Patent: October 15, 2024Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
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Publication number: 20240200089Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: ApplicationFiled: January 24, 2024Publication date: June 20, 2024Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg Bougri, Matthew Parker, Philip A. Lessard
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Patent number: 11932864Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: GrantFiled: May 19, 2022Date of Patent: March 19, 2024Assignee: AGRIVIDA INC.Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
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Publication number: 20220315939Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: ApplicationFiled: May 20, 2022Publication date: October 6, 2022Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
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Publication number: 20220282269Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: ApplicationFiled: May 19, 2022Publication date: September 8, 2022Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
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Patent number: 11390879Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: GrantFiled: May 29, 2018Date of Patent: July 19, 2022Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Matthew Parker, Philip A. Lessard
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Patent number: 11371052Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: GrantFiled: November 3, 2017Date of Patent: June 28, 2022Assignee: AGRIVIDA, INC.Inventors: R. Michael Raab, Oleg Bougri, Philip A. Lessard, Christopher Bonin, Michael B. Lanahan
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Publication number: 20200299709Abstract: Methods and compositions are described for producing a phytase in transgenic maize plants and then incorporating parts of the transgenic maize plants in animal feed. The feed phytase enzyme displays activity across a broad pH range, and tolerance to temperatures that are often encountered during the process of preparing animal feeds. Methods of producing an animal feed that incorporate the transgenic maize plants, parts thereof or plant derived phytases, as well as methods of promoting the release of inorganic phosphate from a phytic acid in an animal, producing an animal meat, or reducing the ratio of intake of an animal feed per weight of the animal meat by feeding an animal with the animal feed incorporating transgenic maize plants are provided.Type: ApplicationFiled: November 3, 2017Publication date: September 24, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Philip A. LESSARD, Christopher BONIN, Michael B. LANAHAN
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Publication number: 20200071716Abstract: The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.Type: ApplicationFiled: May 29, 2018Publication date: March 5, 2020Applicant: AGRIVIDA, INC.Inventors: R. Michael RAAB, Oleg BOUGRI, Matthew PARKER, Philip A. LESSARD
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Patent number: 9598700Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.Type: GrantFiled: March 11, 2013Date of Patent: March 21, 2017Assignee: Agrivida, Inc.Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
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Patent number: 9434954Abstract: Vectors for altering the expression of one or more starch regulation enzymes are provided. Methods of transformation of plant tissues to express elements altering expression of one or more starch regulation enzymes, and resulting transgenic plants are provided. Methods of using the transgenic plants are provided.Type: GrantFiled: June 27, 2011Date of Patent: September 6, 2016Assignee: Agrivida, Inc.Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab
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Publication number: 20130318656Abstract: Vectors for altering the expression of one or more starch regulation enzymes are provided. Methods of transformation of plant tissues to express elements altering expression of one or more starch regulation enzymes, and resulting transgenic plants are provided. Methods of using the transgenic plants are provided.Type: ApplicationFiled: June 27, 2011Publication date: November 28, 2013Applicant: Agrivida, Inc.Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab
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Publication number: 20130269061Abstract: Genetically engineered plants having altered levels of one or more starch regulation enzymes and a polysaccharide degrading enzyme are provided. Methods of genetically engineering plants to express products altering expression of one or more starch regulation enzymes and polysaccharide degrading enzymes, and genetic constructs are provided. Methods of agricultural processing and animal feed using the genetically engineered plants are described.Type: ApplicationFiled: March 11, 2013Publication date: October 10, 2013Inventors: Philip A. Lessard, Michael Lanahan, Vladimir Samoylov, Oleg Bougri, Jonas Emery, R. Michael Raab, Dongcheng Zhang
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Patent number: 8314071Abstract: Certain aspects of the invention relate to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the invention relates to methods of use of said antibiotics.Type: GrantFiled: December 22, 2008Date of Patent: November 20, 2012Assignee: Massachusetts Institute of TechnologyInventors: Anthony J. Sinskey, Philip A. Lessard, Kazuhiro Kurosawa
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Publication number: 20100249051Abstract: Certain aspects of the invention relates to antibiotics, as well as pharmaceutically acceptable salts, pro-drugs and/or analogs thereof. Another aspect of the inventions relates to methods of use of said antibiotics.Type: ApplicationFiled: December 22, 2008Publication date: September 30, 2010Applicant: Massachusetts Institute of TechnologyInventors: Anthony J. Sinskey, Philip A. Lessard, Kazuhiko Kurosawa
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Patent number: 6987017Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.Type: GrantFiled: August 20, 2002Date of Patent: January 17, 2006Assignee: Massachusetts Institute of TechnologyInventors: Stephane Guillouet, Anthony J. Sinskey, Avital A. Rodal, Philip A. Lessard
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Patent number: 6884606Abstract: The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.Type: GrantFiled: January 15, 2002Date of Patent: April 26, 2005Assignee: Massachusetts Institute of TechnologyInventors: Anthony J. Sinskey, Philip A. Lessard, Laura B. Willis
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Publication number: 20030027305Abstract: The present invention concerns an anaplerotic enzyme from Corynebacterium glutamicum which replenishes oxaloacetate consumed during lysine and glutamic acid production in industrial fermentations. In particular, isolated nucleic acid molecules are provided encoding the pyruvate carboxylase protein. Pyruvate carboxylase polypeptides are also provided.Type: ApplicationFiled: January 15, 2002Publication date: February 6, 2003Applicant: Archer-Daniels-Midland CompanyInventors: Anthony J. Sinskey, Philip A. Lessard, Laura B. Willis
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Publication number: 20030008359Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms.Type: ApplicationFiled: August 20, 2002Publication date: January 9, 2003Applicant: Massachussetts Institute of TechnologyInventors: Stephane Guillouet, Anthony J. Sinskey, Avital A. Rodal, Philip A. Lessard
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Patent number: 6451564Abstract: The present invention relates, in general, to the over-production of L-isoleucine by nonhuman organisms. More specifically, the present invention relates to methods for producing L-isoleucine comprising: (a) growing a transformed nonhuman organism under conditions that provide for synthesis of L-isoleucine, wherein the nonhuman organism comprises one or more copies of a transgene comprising at least one nucleotide sequence encoding catabolic threonine dehydratase; wherein the L-isoleucine is synthesized by the transformed nonhuman organism, the synthesis being greater than that of the corresponding non-transformed nonhuman organism; and (b) recovering the L-isoleucine from the culture medium in which the transformed nonhuman organism was cultured.Type: GrantFiled: June 30, 2000Date of Patent: September 17, 2002Assignee: Massachusetts Institute of TechnologyInventors: Stephane Guillouet, Avital A. Rodal, Philip A. Lessard, Anthony J. Sinskey