Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having lateral connector, a cushion with a pair of nozzles, and a clip to secure the cushion to the frame. The frame includes a vent channel and a plurality of vent holes. The frame/cushion includes structure (lugs/cut outs) to prevent the assembly of an unvented frame with an unvented cushion, for safety purposes. The frame includes cored portions that interface with corner lugs provided on the cushion. A patient interface includes a frame, a cushion (nasal mask, nasal-oro mask, nozzles, etc.) and a vent assembly including a pattern of vent holes including at least two rows.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: Provided herein are methods of reducing the incident of disease flares in a subject in need thereof.

Abstract: Provided herein are methods of inhibiting mesangial cell activation in a subject in need thereof.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: Disclosed are systems and methods for secure and seamless set up and modification of bolus calculator parameters for a bolus calculator tool by a health care provider (HCP). In one aspect, a method for enabling HCP set up of a bolus calculator includes providing a server accessible by both an HCP and a patient; upon login by the HCP, displaying, or transmitting for display, a fillable form, the fillable form including one or more fields for entry of one or more bolus calculator parameters; receiving data from the fillable form, the data corresponding to one or more bolus calculator parameters; and upon login by the patient, transmitting data to a device associated with the patient, the transmitted data based on the received data, where the transmitted data corresponds to one or more of the bolus calculator parameters in a format suitable for entry to a bolus calculator.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.

Abstract: Provided herein are methods of treating kidney diseases in a subject in need thereof.

Abstract: Network access node virtual fabrics configured dynamically over an underlay network are described. A centralized controller, such as a software-defined networking (SDN) controller, of a packet switched network is configured to establish one or more virtual fabrics as overlay networks on top of the physical underlay network of the packet switched network. For example, the SDN controller may define multiple sets of two of more access nodes connected to the packet switched network, and the access nodes of a given one of the sets may use a new data transmission protocol, referred to generally herein as a fabric control protocol (FCP), to dynamically setup tunnels as a virtual fabric over the packet switched network. The FCP tunnels may include all or a subset of the parallel data paths through the packet switched network between the access nodes for a given virtual fabric.

Abstract: This disclosure describes techniques that include performing cryptographic operations (encryption, decryption, generation of a message authentication code). Such techniques may involve the data processing unit performing any of multiple modes of encryption, decryption, and/or other cryptographic operation procedures or standards, including, Advanced Encryption Standard (AES) cryptographic operations. In some examples, the security block is implemented as a unified, multi-threaded, high-throughput encryption and decryption system for performing multiple modes of AES operations.

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: An air curtain air cleaner and sanitation system that incorporates established active UVC light projection technology with threshold air delivery air curtains to provide conditioned airflow by outward UVC light beam projection into the return airflow in a structure while maintaining an air control barrier between openings in a structure.

Abstract: A stand-up inflatable paddle board (2) comprising (i) a deck (4); (ii) a valve (6) for enabling the stand-up inflatable paddle board (2) to be inflated and deflated; (iii) indicator means (12) for indicating that the stand-up inflatable paddle board (2) requires at least one fold which is longitudinal when the stand-up inflatable paddle board (2) is to be placed in a deflated condition; and (iv) at least one deck pad (8, 10) which extends longitudinally of the deck (4) and which is for receiving a user of the stand-up inflatable paddle board (2), and the stand-up inflatable paddle board (2) being such that (v) the deck pad (8, 10) causes the stand-up inflatable paddle board to have a gap (14) which permits the fold to be effected about the gap (14).

Abstract: A fabric control protocol is described for use within a data center in which a switch fabric provides full mesh interconnectivity such that any of the servers may communicate packet data for a given packet flow to any other of the servers using any of a number of parallel data paths within the data center switch fabric. The fabric control protocol enables spraying of individual packets for a given packet flow across some or all of the multiple parallel data paths in the data center switch fabric and, optionally, reordering of the packets for delivery to the destination. The fabric control protocol may provide end-to-end bandwidth scaling and flow fairness within a single tunnel based on endpoint-controlled requests and grants for flows. In some examples, the fabric control protocol packet structure is carried over an underlying protocol, such as the User Datagram Protocol (UDP).

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having lateral connector, a cushion with a pair of nozzles, and a clip to secure the cushion to the frame. The frame includes a vent channel and a plurality of vent holes. The frame/cushion includes structure (lugs/cut outs) to prevent the assembly of an unvented frame with an unvented cushion, for safety purposes. The frame includes cored portions that interface with corner lugs provided on the cushion. A patient interface includes a frame, a cushion (nasal mask, nasal-oro mask, nozzles, etc.) and a vent assembly including a pattern of vent holes including at least two rows.

Abstract: This invention relates to a process for producing lipids and amino acids from a gaseous substrate comprising methane and oxygen. The process uses a culture of a methanotrophic microorganism in a liquid nutrient medium. The methanotrophic microorganism can be a Methylomicrobium bacterium and more specifically Methylomicrobium buryatense 5GB1. The lipid products can be in the cellular membrane of the methanotroph and can be extracted in a separate extraction zone.

Abstract: Disclosed are systems and methods for secure and seamless set up and modification of bolus calculator parameters for a bolus calculator tool by a health care provider (HCP). In one aspect, a method for enabling HCP set up of a bolus calculator includes providing a server accessible by both an HCP and a patient; upon login by the HCP, displaying, or transmitting for display, a fillable form, the fillable form including one or more fields for entry of one or more bolus calculator parameters; receiving data from the fillable form, the data corresponding to one or more bolus calculator parameters; and upon login by the patient, transmitting data to a device associated with the patient, the transmitted data based on the received data, where the transmitted data corresponds to one or more of the bolus calculator parameters in a format suitable for entry to a bolus calculator.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.