Abstract: Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.

Abstract: The present invention generally relates to high rate adsorbents and a method for their manufacture involving the steps of component mixing, extrusion, spheronization and calcination. The component mixing can involve both dry mixing in addition to wet mixing of an adsorbent with a binder, if required, and a fluid such as water. The paste so formed from the mixing stage is extruded to produce pellets which are optionally converted to beads by spheronization using in one embodiment, a marumerizer. The product is harvested and calcined to set any binder or binders used and/or burn out any additives or processing aids. This basic manufacturing scheme can be augmented by extra processing steps including ion exchange and activation to alter the composition of the adsorbents, as required.

Abstract: Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.

Abstract: The present invention relates generally to a composite adsorbent comprising at least a zeolite-containing CO2 removal adsorbent and 10% or more of a metal oxide having a heat capacity of at least 20 cal/mol-° K (83.7 J/(mol·K). The composite is preferably used in a multi-layered adsorption system in a cyclic adsorption process. The adsorption system comprises two or more layers wherein the first layer is at least a water vapor removal adsorbent, such as activated alumina, and the second layer is the novel composite adsorbent. The adsorption system is preferably used in a PSA prepurification process prior to cryogenic air separation.

Abstract: A pharmaceutical depot comprising (i) 5-fluoro-2-[[(1S)-1-(5-fluoro-2-pyridyl)ethyl]amino]-6-[(5-isopropoxy-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation.

Abstract: Adsorbent compositions useful in adsorption and separation processes are made using silicone-derived binding agents. The adsorbent compositions are made from crystallite aluminosilicate particles bound with silicone-derived binding agents, and optionally small amounts of a clay binder, to form agglomerated crystallite particles and are calcined to volatilize the organic components associated with the silicone-derived binding agents. The agglomerated crystallite particles have superior pore structures and superior crush strengths at low binder concentrations and exhibit enhanced N2 adsorption rates and capacities when used in air separation processes.

Abstract: The present invention relates generally to compositions useful in adsorption and reactive processes comprising an adsorbent powder, such as a zeolite, and a binder mixed to form an agglomerate having a porosity of 0.30??p?0.42 and a N2 pore diffusivity Dp?3.5×10?6 m2/s and wherein the mean particle diameter of the crystalline zeolite powder is 10 ?m or less; the mean particle diameter of the binder is 0.10 dA or less, and the binder concentration is 10% or less expressed on a dry weight basis.

Abstract: An anti-flashback needle adapter inhibits the uncontrolled jetting of blood upon the insertion of an arterial access needle into a blood vessel. An inner wall defines at least one inner port and an outer wall defines at least one outer port in fluid communication with the inner port. As blood enters the device from the arterial access needle, it is diverted first through the inner port and then through the outer port, which diversion has a baffle effect and dissipates the energy of the blood flow. This prevents the jetting of blood and potential contamination of nearby people and objects. A funnel member allows for the insertion of a guide wire into the arterial access needle while maintaining the blood flow dissipation properties of the device.

Abstract: A computer system (10) for identifying and delivering services to patients of a pharmacy includes: an information module (20) for obtaining and storing information about a pharmacy patient; an electronic processing tool (22) for processing said patient information from the information module (20) and identifying at least one pharmacy related service program for delivery to a patient qualified for the service program based on said processed patient information; an advisory tool (26) enabling a pharmacy to advise a patient of said identified service program for said qualified patient as identified by said electronic processing tool (22); and a service delivery module (40) for delivering said at least one identified service program to said qualified patient by use of a plug-in application (31-34) corresponding with said identified service program.

Abstract: One embodiment of the present invention sets forth a technique for performing nested kernel execution within a parallel processing subsystem. The technique involves enabling a parent thread to launch a nested child grid on the parallel processing subsystem, and enabling the parent thread to perform a thread synchronization barrier on the child grid for proper execution semantics between the parent thread and the child grid. This technique advantageously enables the parallel processing subsystem to perform a richer set of programming constructs, such as conditionally executed and nested operations and externally defined library functions without the additional complexity of CPU involvement.

Abstract: Systems and methods for auto-throttling encapsulated compute tasks. A device driver may configure a parallel processor to execute compute tasks in a number of discrete throttled modes. The device driver may also allocate memory to a plurality of different processing units in a non-throttled mode. The device driver may also allocate memory to a subset of the plurality of processing units in each of the throttling modes. Data structures defined for each task include a flag that instructs the processing unit whether the task may be executed in the non-throttled mode or in the throttled mode. A work distribution unit monitors each of the tasks scheduled to run on the plurality of processing units and determines whether the processor should be configured to run in the throttled mode or in the non-throttled mode.

Abstract: The invention provides mixtures of linear nucleic acid probes, including circularizing “capture” probes, capable of massively multiplex capture of one or more sequences of interest from a plurality of target organisms. The methods provided by the invention enable rapid, precise, and economical detection of one or more organisms of interest, such as common pathogens.

Abstract: Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.

Abstract: One embodiment of the present invention sets forth a technique for automatic launching of a dependent task when execution of a first task completes. Automatically launching the dependent task reduces the latency incurred during the transition from the first task to the dependent task. Information associated with the dependent task is encoded as part of the metadata for the first task. When execution of the first task completes a task scheduling unit is notified and the dependent task is launched without requiring any release or acquisition of a semaphore. The information associated with the dependent task includes an enable flag and a pointer to the dependent task. Once the dependent task is launched, the first task is marked as complete so that memory storing the metadata for the first task may be reused to store metadata for a new task.

Abstract: One embodiment of the present invention sets forth a technique for performing low latency computation on a parallel processing subsystem. A low latency functional node is exposed to an operating system. The low latency functional node and a generic functional node are configured to target the same underlying processor resource within the parallel processing subsystem. The operating system stores low latency tasks generated by a user application within a low latency command buffer associated with the low latency functional node. The parallel processing subsystem advantageously executes tasks from the low latency command buffer prior to completing execution of tasks in the generic command buffer, thereby reducing completion latency for the low latency tasks.

Abstract: One embodiment of the present invention sets forth a technique for enabling the insertion of generated tasks into a scheduling pipeline of a multiple processor system allows a compute task that is being executed to dynamically generate a dynamic task and notify a scheduling unit of the multiple processor system without intervention by a CPU. A reflected notification signal is generated in response to a write request when data for the dynamic task is written to a queue. Additional reflected notification signals are generated for other events that occur during execution of a compute task, e.g., to invalidate cache entries storing data for the compute task and to enable scheduling of another compute task.

Abstract: One embodiment of the present invention sets forth a technique instruction level and compute thread array granularity execution preemption. Preempting at the instruction level does not require any draining of the processing pipeline. No new instructions are issued and the context state is unloaded from the processing pipeline. When preemption is performed at a compute thread array boundary, the amount of context state to be stored is reduced because execution units within the processing pipeline complete execution of in-flight instructions and become idle. If, the amount of time needed to complete execution of the in-flight instructions exceeds a threshold, then the preemption may dynamically change to be performed at the instruction level instead of at compute thread array granularity.

Abstract: One embodiment of the present invention sets forth a technique for managing the allocation and release of resources during multi-threaded program execution. Programmable reference counters are initialized to values that limit the amount of resources for allocation to tasks that share the same reference counter. Resource parameters are specified for each task to define the amount of resources allocated for consumption by each array of execution threads that is launched to execute the task. The resource parameters also specify the behavior of the array for acquiring and releasing resources. Finally, during execution of each thread in the array, an exit instruction may be configured to override the release of the resources that were allocated to the array. The resources may then be retained for use by a child task that is generated during execution of a thread.

Abstract: One embodiment of the present invention sets forth a technique for instruction level execution preemption. Preempting at the instruction level does not require any draining of the processing pipeline. No new instructions are issued and the context state is unloaded from the processing pipeline. Any in-flight instructions that follow the preemption command in the processing pipeline are captured and stored in a processing task buffer to be reissued when the preempted program is resumed. The processing task buffer is designated as a high priority task to ensure the preempted instructions are reissued before any new instructions for the preempted context when execution of the preempted context is restored.

Abstract: The present invention relates generally to a composite adsorbent comprising at least a zeolite-containing CO2 removal adsorbent and 10% or more of a metal oxide having a heat capacity of at least 20 cal/mol-° K (83.7 J/(mol·K). The composite is preferably used in a multi-layered adsorption system in a cyclic adsorption process. The adsorption system comprises two or more layers wherein the first layer is at least a water vapor removal adsorbent, such as activated alumina, and the second layer is the novel composite adsorbent. The adsorption system is preferably used in a PSA prepurification process prior to cryogenic air separation.