Abstract: This invention is related to artificial intelligent (AI) system with biodegradable endovascular nanoscale-structured flowmeter layer for monitoring cerebral blood flow during mental performance, blood flow through in-stent re-stenosis (ISR) and thromboembolism. The invention is based on blood flow inducing changes in magnetization of nanoscale microwave ferrites. These changes in magnetization, then interact with the microwave in a frequency-dependent manner using a microprocessor for processing and transmission via cellular phone network to human-machine interface for control of computers, machines or weapon systems. It detects reduction of blood flow through ISR and microembolic signals due to thromboembolism of the vessel much earlier before severe symptoms develop.

Abstract: The present invention provides monitoring of brain blood circulation in a patient with cardiac pacemaker for the prevention of symptoms associated with pacemaker syndrome and stroke. The monitoring of brain blood flow velocity is performed using a transcranial Doppler ultrasound device synchronized with an implanted cardiac pacemaker, to select the pacing mode that enhances cerebral perfusion in the patient. The system further detects microembolic signals in the cerebral circulation and triggers sonothrombolysis as well as release of thromolytic and neuroprotective agents for clot dissolution.

Abstract: The present invention generally relates to mental performance monitoring of brain activity that implements computing using blockchain and artificial intelligence technologies. Specifically, this invention relates to creating a blockchain from data obtained from a mental performance monitoring device that measures in real-time the mental activity and applying artificial intelligence machine-learning for pattern recognition of ‘best performance’ envelope to raise work efficiency, certify cognitive biometric status, detect cerebral microemboli, perform motor, sensory, facial, object and color processing tasks.

Abstract: The present invention generally relates to mental performance monitoring of brain activity that implements computing using blockchain and artificial intelligence technologies. Specifically, this invention relates to creating a blockchain from data obtained from a mental performance monitoring device that measures in real-time the mental activity and applying artificial intelligence machine-learning for pattern recognition of ‘best performance’ envelope to raise work efficiency, certify cognitive biometric status, detect cerebral microemboli, perform motor, sensory, facial, object and color processing tasks.

Abstract: The present invention provides a medical emergency first aid during accidents using cervical spine collar to insert a splint for stabilization, resuscitation, initiation of mild to moderate external hypothermia, and vital signs monitoring in victims of traumatic brain (TBI) and cervical spinal injury (CSI). The cervical spine collar of the present invention is housed in the head rest of the vehicle seat and could be deployed automatically using artificial intelligence (AI) or manually by an assistant. One embodiment incorporates a protective helmet with cooling apparatus to induce mild to moderate external hypothermia of the brain to prevent deleterious effects of TBI.

Abstract: The present invention provides a method for monitoring long-term potentiation and long-term depression, comprising placing a subject in head down bed rest position and monitoring in real-time cerebral mean blood flow velocity using a transcranial Doppler device during psychophysiologic tasks. The method involves using Fourier analysis of mean blood flow velocity data to derive spectral density peaks of cortical and subcortical processes. The effect of head-down bed rest at different time intervals is seen as accentuation of the cortical peaks in long-term potentiation and attenuation of subcortical peaks in long-term depression, relative to baseline. The effect of different interventions could be evaluated for research, diagnosis, rehabilitation and therapeutic use.

Abstract: A system for life support in high performance avionics that utilizes cerebral blood flow velocity measurements and responses to real-time neuropsychological tests of brain function, to accomplish prevention of gravitational loss of consciousness, determination of cognitive state-of-being of the crewmember, regulation of autonomy-decision making level, while taking into account individualized +Gz-tolerance and cognitive abilities under +Gz-stress, comprising a transcranial Doppler device, attached to a microcomputer, operatively connected to the mainframe avionic computer.

Abstract: The present invention is a method for assessment of color processing mechanism in the human brain using cerebral blood flow velocity monitoring, specifically transcranial Doppler ultrasound. The method including steps of transluminating color discs from a light source of a specific color temperature, which act on the visual pathways and color centers to alter mean blood flow velocity in the cerebral arteries. The mean flow velocity is analyzed and using Fourier computation to calculate spectral density estimates. Opponent mechanism in the cortical and subcortical regions determined as opposing tendency for short wavelength versus medium wavelength or for medium wavelength versus long wavelength colors. The method is applied for diagnosis, and treatment of variety of conditions.

Abstract: The present invention provides a method for determining the cerebral hemodynamic model for depression, using carotid duplex ultrasound to establish percent stenosis of a right external carotid artery and a left external carotid artery, and transcranial Doppler ultrasound instrument to measure mean flow velocity within the cerebral arteries including the right and left internal carotid arteries, right and left middle cerebral arteries, right and left anterior cerebral arteries, right and left posterior cerebral arteries, and basilar artery. Percent carotid stenosis and mean flow velocity values in cerebral arteries are used to determine the cerebral hemodynamic model associated with depression in men and women, respectively.

Abstract: The present invention provides a method and system for determining the cerebral hemodynamic model for depression, using carotid duplex ultrasound to establish percent stenosis of the extracranial right and left internal carotid arteries and transcranial Doppler ultrasound instrument to measure mean flow velocity within the cerebral including the right and left internal carotid arteries, right and left middle cerebral arteries, right and left anterior cerebral arteries, right and left posterior cerebral arteries, and basilar artery. The percent carotid stenosis and the mean flow velocity values in cerebral arteries are used to determine the cerebral hemodynamic model associated with depression in men and women, respectively.

Abstract: The present invention provides a method for monitoring long-term potentiation and long-term depression, comprising placing a subject in head down rest position and monitoring in real-time cerebral mean blood flow velocity using a transcranial Doppler device during psychophysiologic tasks. The method involves using Fourier analysis of mean blood flow velocity data to derive spectral density peaks of cortical and subcortical processes. The effect of head-down rest at different time intervals is seen as accentuation of the cortical peaks in long-term potentiation and attenuation of subcortical peaks in long-term depression. The effect of different interventions could be evaluated for research, diagnosis, rehabilitation and therapeutic use.

Abstract: The present invention is a method for assessment of color processing mechanism in the human brain using cerebral blood flow velocity monitoring, specifically transcranial Doppler ultrasound. The method including steps of transluminating color discs from a light source of a specific color temperature, which act on the visual pathways and color centers to alter mean blood flow velocity in the cerebral arteries. The mean flow velocity is analyzed and using Fourier computation to calculate spectral density estimates. Opponent mechanism in the cortical and subcortical regions determined as opposing tendency for short wavelength versus medium wavelength or for medium wavelength versus long wavelength colors. The method is applied for diagnosis, and treatment of variety of conditions.

Abstract: The invention relates to a method for hypothermia and rewarming of the cerebrospinal fluid in the brain. In one embodiment, cooling and rewarming of the cerebrospinal fluid is accomplished by applying cooling and rewarming elements externally placed in contact with the skin overlying the cerebrospinal fluid cisterns at the back of the head and spine regions of a patient. In another embodiment, hypothermia and rewarming is accomplished using a double barrel ventricular catheter placed within the lateral ventricles with one catheter used for heat exchange and the other for drainage of excess cerebrospinal fluid. In yet another embodiment of the invention, hypothermia and rewarming is accomplished using a loop catheter with fluid running through the loop placed in the lateral ventricles.

Abstract: A noninvasive method to determine cerebral blood flow velocity response to face recognition tasks of a human subject, including steps of obtaining a subject's cerebral blood flow velocity in cerebral arteries on both sides of the brain using a microcomputer integrated with a transcranial Doppler ultrasound instrument with two probes placed on the temples and sample volumes focused on cerebral vessels on both sides and calculating laterality index for both arteries. Simultaneously, testing the subject with face or object processing tasks presented on the screen of a digital computer while monitoring the mean blood flow velocity during each stage of the task in real-time. Processing the acquired data to determine the spectrum analysis using a microcomputer that is operatively connected to a computer workstation for image retrieval and cross matching.

Abstract: A non-invasive method and system to determine face and object processing in a human subject, said method with high temporal resolution, user-friendly and portable, including steps of obtaining a subjects baseline cerebral blood flow velocity in cerebral arteries using a transcranial Doppler ultrasound instrument with sample volumes focused on cerebral vessels on both sides using two probes place on the temples and calculating laterality index for both arteries. Simultaneously, testing the subject with face and object processing tasks presented on the screen of a digital computer and using a computer input peripheral device while simultaneously monitoring the mean blood flow velocity during each stage of the task in real-time. Processing the acquired data using a microprocessor operatively connected to a computer work station for image retrieval.

Abstract: The present invention is related to cerebral blood flow velocity monitoring method and system, specifically a transcranial Doppler device for odor matching and odor selection in canine and human subjects. The method and system is non-invasive with high temporal resolution, user-friendly and portable, including steps of obtaining a subject's baseline mean blood flow velocity in cerebral arteries using transcranial Doppler instrument with sample volume focused on cerebral vessels on both sides using two probes placed on the temples and calculating laterality index for both arteries. Simultaneously, testing the subject with odors while monitoring mean blood flow velocity during each odor in real-time. The acquired data is processed using an operatively attached microprocessor and using a cellular telephone to communicate the results to a computer workstation for further data analysis and storage.

Abstract: The present invention is related to cerebral blood flow velocity monitoring method and system, specifically a transcranial Doppler device for odor matching and odor selection in canine and human subjects. The method and system is non-invasive with high temporal resolution, user-friendly and portable, including steps of obtaining a subject's baseline mean blood flow velocity in cerebral arteries using transcranial Doppler instrument with sample volume focused on cerebral vessels on both sides using two probes placed on the temples and calculating laterality index for both arteries. Simultaneously, testing the subject with odors while monitoring mean blood flow velocity during each odor in real-time. The acquired data is processed using an operatively attached microprocessor and using a cellular telephone to communicate the results to a computer workstation for further data analysis and storage.

Abstract: A non-invasive method and system to determine face and object processing in a human subject, said method with high temporal resolution, user-friendly and portable, including steps of obtaining a subject's baseline cerebral blood flow velocity in cerebral arteries using a transcranial Doppler ultrasound instrument with sample volumes focused on cerebral vessels on both sides using two probes placed on the temples and calculating laterality index for both arteries. Simultaneously, testing the subject with face and object processing tasks presented on the screen of a digital computer and using a computer input peripheral device while simultaneously monitoring the mean blood flow velocity during each stage of the task in real-time. Processing the acquired data using a microprocessor operatively connected to a computer workstation for image retrieval.

Abstract: A system for automatic manipulation of a transcranial Doppler probe device designed for placement on a patient's head comprising a bi-temporal probe hanger, a cylindrical probe housing having an inner electrical wiring, an ultrasound transducer with cable affixed on the probe cylindrical base having a coil, said probe cylindrical base placed within the cylindrical probe housing, a spring system affixed to provide perpendicular pressure on the probe cylindrical base, a system of roller balls, a locking system to affix the cylindrical probe housing to the frame of the bi-temporal probe hanger, a system software program and microprocessor for controlling the probe position, and a removable handle attached to the said probe cylindrical base. The system software ‘learns’ probe angulations after initial manual manipulations and then performs cerebral vessel insonation using electromotive force independent of operator.

Abstract: A method of operating a neural network for ecological and biological system modeling having a plurality of hidden layer neurons said method comprising: a plurality of network inputs and at least one network output, said plurality of neurons, each receiving a plurality of inputs applied to the network, reproduces the network using a regression model, and compares the output values with given target values, and using the comparison and goodness of fit to set the learning rules. The network does not require repetitive training and yields a global minimum for each given set of input variables.