Abstract: The invention relates to a cerebral blood flow velocity monitoring system and method that comprises a transcranial Doppler ultrasound device that is adapted to be implanted in the human body, an oximeter, an external handheld computer and a drug delivery system. The system provides for monitoring of microembolic signals and operatively activates the drug delivery system for infusion of medication into the blood circulation for thrombolysis and neuroprotection.

Abstract: A system for automatic manipulation of a transcranial Doppler probe device designed for placement on a patient's head comprising a bi-temporal probe hanger, a cylindrical probe housing having an inner electrical wiring, an ultrasound transducer with cable affixed on the probe cylindrical base having a coil, said probe cylindrical base placed within the cylindrical probe housing, a spring system affixed to provide perpendicular pressure on the probe cylindrical base, a system of roller balls, a locking system to affix the cylindrical probe housing to the frame of the bi-temporal probe hanger, a system software program and microprocessor for controlling the probe position, and a removable handle attached to the said probe cylindrical base. The system software ‘learns’ probe angulations after initial manual manipulations and then performs cerebral vessel insonation using electromotive force independent of operator.

Abstract: A non-invasive method and system to determine the mental performance capacity of a human subject to perform a given task, said method with high temporal resolution, user-friendly and portable, including steps of obtaining a subject's baseline cerebral blood flow velocity in cerebral arteries using a transcranial Doppler ultrasound instrument with sample volumes focused on cerebral vessels on both sides using two probes placed on the temples and calculating laterality index for both arteries. Simultaneously, testing the subject with tasks of mental performance presented on the screen of a digital computer and using a computer input peripheral device while simultaneously monitoring the mean blood flow velocity during each stage of the task in real-time. Processing the acquired data using a microprocessor and communicating the determined mental performance indices via a cellular telephone circuit to a remote computer or mission control.