Patents by Inventor Philip James Stephens

Philip James Stephens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20250146077
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: September 9, 2024
    Publication date: May 8, 2025
    Applicant: Foundation Medicine, Inc.
    Inventors: Maureen T. CRONIN, Garrett Michael FRAMPTON, Doron LIPSON, Vincent A. MILLER, Gary PALMER, Jeffrey S. ROSS, Philip James STEPHENS, Roman YELENSKY
  • Methods of treating cholangiocarcinoma
    Patent number: 12274699
    Abstract: Methods and compositions for treating cholangiocarcinoma.
    Type: Grant
    Filed: June 30, 2023
    Date of Patent: April 15, 2025
    Assignee: Foundation Medicine, Inc.
    Inventors: Siraj Mahamed Ali, Matthew J. Hawryluk, Jie He, Doron Lipson, Vincent A. Miller, Jeffrey S. Ross, Philip James Stephens
  • KIF5B-RET fusion molecules and uses thereof
    Patent number: 12239648
    Abstract: Novel RET fusion molecules and uses are disclosed.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: March 4, 2025
    Assignee: Foundation Medicine, Inc.
    Inventors: Sean R. Downing, Matthew J. Hawryluk, Doron Lipson, Alexander N. Parker, Philip James Stephens
  • Optimization of multigene analysis of tumor samples
    Patent number: 12180540
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: December 31, 2024
    Assignee: Foundation Medicine, Inc.
    Inventors: Doron Lipson, Geoffrey Alan Otto, Alexander Nevin Parker, Philip James Stephens, Sean R. Downing, Mirna Jarosz, Mikhail G. Shapiro, Roman Yelensky
  • METHODS OF TREATING CANCER
    Publication number: 20240392378
    Abstract: Methods and compositions for treating cancer such as melanomas are disclosed.
    Type: Application
    Filed: June 22, 2023
    Publication date: November 28, 2024
    Applicants: Foundation Medicine, Inc., Vanderbilt University
    Inventors: Garrett Michael FRAMPTON, Roman YELENSKY, James Xin SUN, Douglas Buckner JOHNSON, Christine Marie LOVLY, Jeffrey Alan SOSMAN, David FABRIZIO, Philip James STEPHENS, Vincent A. MILLER
  • Estrogen receptor mutations and uses thereof
    Patent number: 12116638
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: October 15, 2024
    Assignee: Foundation Medicine, Inc.
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • METHODS OF TREATING CHOLANGIOCARCINOMA
    Publication number: 20230372338
    Abstract: Methods and compositions for treating cholangiocarcinoma.
    Type: Application
    Filed: June 30, 2023
    Publication date: November 23, 2023
    Applicant: Foundation Medicine, Inc.
    Inventors: Siraj Mahamed ALI, Matthew J. HAWRYLUK, Jie HE, Doron LIPSON, Vincent A. MILLER, Jeffrey S. ROSS, Philip James STEPHENS
  • Methods of treating cholangiocarcinoma
    Patent number: 11771698
    Abstract: Methods and compositions for treating cholangiocarcinoma.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: October 3, 2023
    Assignee: Foundation Medicine, Inc.
    Inventors: Siraj Mahamed Ali, Matthew J. Hawryluk, Jie He, Doron Lipson, Vincent A. Miller, Jeffrey S. Ross, Philip James Stephens
  • Human papilloma virus as predictor of cancer prognosis
    Patent number: 11766439
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Grant
    Filed: June 10, 2021
    Date of Patent: September 26, 2023
    Assignees: FOUNDATION MEDICINE, INC., UCL BUSINESS LTD
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Methods of treating cancer
    Patent number: 11725247
    Abstract: Methods and compositions for treating cancer such as melanomas are disclosed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: August 15, 2023
    Assignees: FOUNDATION MEDICINE, INC., VANDERBILT UNIVERSITY
    Inventors: Garrett Michael Frampton, Roman Yelensky, James Xin Sun, Douglas Buckner Johnson, Christine Marie Lovly, Jeffrey Alan Sosman, David Fabrizio, Philip James Stephens, Vincent A. Miller
  • KIF5B-RET FUSION MOLECULES AND USES THEREOF
    Publication number: 20230241065
    Abstract: Novel RET fusion molecules and uses are disclosed.
    Type: Application
    Filed: August 4, 2022
    Publication date: August 3, 2023
    Applicant: FOUNDATION MEDICINE, INC.
    Inventors: Sean R. DOWNING, Matthew J. HAWRYLUK, Doron LIPSON, Alexander N. PARKER, Philip James STEPHENS
  • OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES
    Publication number: 20230148412
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Application
    Filed: July 13, 2022
    Publication date: May 11, 2023
    Applicant: Foundation Medicine, Inc.
    Inventors: Doron LIPSON, Geoffrey Alan OTTO, Alexander Nevin PARKER, Philip James STEPHENS, Sean R. DOWNING, Mirna JAROSZ, Mikhail G. SHAPIRO, Roman YELENSKY
  • NTRK1 fusion molecules and uses thereof
    Patent number: 11578372
    Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: February 14, 2023
    Assignee: Foundation Medicine, Inc.
    Inventors: Matthew J. Hawryluk, Doron Lipson, Vincent A. Miller, Philip James Stephens
  • Optimization of multigene analysis of tumor samples
    Patent number: 11421265
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: August 23, 2022
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Doron Lipson, Geoffrey Alan Otto, Alexander Nevin Parker, Philip James Stephens, Sean R. Downing, Mima Jarosz, Mikhail G. Shapiro, Roman Yelensky
  • NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF
    Publication number: 20220251667
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Application
    Filed: February 16, 2022
    Publication date: August 11, 2022
    Applicant: Foundation Medicine, Inc.
    Inventors: Maureen T. CRONIN, Garrett Michael FRAMPTON, Doron LIPSON, Vincent A. MILLER, Gary PALMER, Jeffrey S. ROSS, Philip James STEPHENS, Roman YELENSKY
  • METHODS OF TREATING UROTHELIAL CARCINOMA
    Publication number: 20220145402
    Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
    Type: Application
    Filed: November 24, 2021
    Publication date: May 12, 2022
    Applicant: Foundation Medicine, Inc.
    Inventors: Siraj Mahamed ALI, Matthew J. HAWRYLUK, Jeffrey S. ROSS, Philip James STEPHENS
  • HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS
    Publication number: 20220096483
    Abstract: Methods of treating a head and neck cancer are disclosed.
    Type: Application
    Filed: June 10, 2021
    Publication date: March 31, 2022
    Inventors: Chris Hendrik Boshoff, Timothy Robert Fenton, Matthias Alexander Lechner, Philip James Stephens, Matthew J. Hawryluk, Garrett Michael Frampton, Roman Yelensky
  • Estrogen receptor mutations and uses thereof
    Patent number: 11286532
    Abstract: Novel mutant ESR1 molecules and uses are disclosed.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: March 29, 2022
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Maureen T. Cronin, Garrett Michael Frampton, Doron Lipson, Vincent A. Miller, Gary Palmer, Jeffrey S. Ross, Philip James Stephens, Roman Yelensky
  • System and method for managing genomic information
    Patent number: 11158425
    Abstract: Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: October 26, 2021
    Assignee: FOUNDATION MEDICINE, INC.
    Inventors: Helena Futscher de Deus, Rachel Lauren Erbach, Ronald David Collette, Alexander N. Parker, Michael Pellini, Gary Palmer, Mary Pat Lancelotta, Matthew J. Hawryluk, Philip James Stephens, Eric Karl Neumann
  • Optimization of multigene analysis of tumor samples
    Patent number: 11136619
    Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: October 5, 2021
    Assignee: Foundation Medicine, Inc.
    Inventors: Doron Lipson, Geoffrey Alan Otto, Alexander Nevin Parker, Philip James Stephens, Sean R. Downing, Mima Jarosz, Mikhail G. Shapiro, Roman Yelensky