Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: Techniques for planning resources using block and route information are described. In an example, a computing system determines a demand for item transportation expected during a planning horizon. The computing system determines information about a pre-planned transportation resource available during the planning horizon and costs associated with the pre-planned transportation resource. The computing system uses an optimization model to determine a block having a time length, a tour to transport, during the block, a first portion of the demand using the pre-planned transportation resource, and a second portion of the demand to be transported using an on-demand transportation resource. The computing system indicates, to a first computing device of the pre-planned transportation resource, an assignment of the block to the pre-planned transportation resource.

Abstract: A method of inverting workpieces in a mass production process includes: advancing an end effector in electronic synchronization with advancement of a carrier to synchronize arrival of the carrier at a stop position with arrival of the end effector at an unloading position, in which the end effector is in alignment with a workpiece held by the carrier for engaging the workpiece; while the end effector is in engagement with the workpiece, retracting the end effector away from the carrier to unload the workpiece from the carrier and advancing the end effector back toward the carrier to load the workpiece back into the carrier; and rotating the end effector relative to the carrier to invert the workpiece in electronic synchronization with the retracting and advancing of the end effector for loading the workpiece back into the carrier when inverted.

Abstract: The present disclosure provides a compound represented by structural Formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: Techniques for generating an item transmission portal are described herein. First information for a plurality of carriers may be maintained which includes a capacity for each carrier. Historical capacity requirements for geographic locations may be maintained. For each geographic location a forecast of future capacity requirements, for each week of a plurality of weeks, may be generated based on the historical capacity requirements. A plurality of documents may be generated for each geographic location based on the forecast and the first information. A value may be determined for each document based on a time and capacity commitment for each document, the historical capacity requirements, and the forecast. A user interface may be generated that includes the plurality of documents and corresponding determined values. The user interface may be updated to reflect acceptance of a specific document by a carrier in response to input received via the user interface.

Abstract: Method of producing an activated clostridial neurotoxin. Composition comprising an activated clostridial neurotoxin. Method of treatment using a composition comprising an activated clostridial neurotoxin.

Abstract: A method of operating an EWOD device to employs a magnetic field to separate magnetically responsive particles from a polar liquid droplet. The method includes the steps of dispensing a liquid droplet onto an element array of the EWOD device, wherein the liquid droplet includes magnetically responsive particles; performing an electrowetting operation to move the liquid droplet along the element array to a location relative to a magnet element in proximity to that location of the EWOD device; operating the magnet element to apply a magnetic field to the liquid droplet, wherein at least a portion of the magnetically responsive particles aggregate within the liquid droplet in response to the magnetic field; and separating the aggregated magnetically responsive particles from the liquid droplet with the magnetic field, wherein the aggregated magnetically responsive particles move in response to the magnetic field to a location on the element array in proximity to the magnet element.

Abstract: The present disclosure relates to comparisons of data over time and generating recommendations to create such comparisons. A visualization in an analytics application may include a plurality of data points and a user may select of one or more of the data points to configure the visualization. If the context of the visualization is based on time, the software may determine whether the one or more selected data points includes the current time period. If so, comparisons of the data over time may be included in the visualization and creation of these comparisons may be recommended to the user. One or more data comparisons may be determined by comparing each of the one or more selected data points to a corresponding data point in a previous time period. An updated visualization including the selected data points and the data comparisons may be provided.

Abstract: A microfluidic control system for controlling an EWOD device has an enhanced thermal control system for generating a temperature profile within an EWOD device that is inserted into the microfluidic control system. The microfluidic control system includes a housing that defines an aperture for receiving an EWOD device; an active heating component located within the housing at a base of the aperture; and a lid attached to the housing that is moveable between a closed position and an open position, the lid including a thermal control component. When the lid is in the closed position, the thermal control component is positioned at the aperture and aligned oppositely from the active heating component. The active heating component may include a plurality of independently controllable individual heating elements, and the thermal control component may include a respective plurality of individual thermal control elements.

Abstract: An EWOD device and a related method of performing a digital biological assay are described that employs two volume measurements for enhanced assay determination. The method includes partitioning a sample reservoir and measuring the volume of each partition; initiating a biological assay wherein the biological assay includes measuring a partition property and a volume of each partition in real time as part of determining a concentration of the product substance in each partition based on the measured partition property and volume; and categorizing the partitions by a number of biological entities contained in each partition from which the number of biological entities may be calculated, which in turn may be used to calculate the total number of biological entities or concentration in the sample reservoir. The method further may include an enhanced partitioning process that minimizes variation in the volume of the partitions.

Abstract: A method of digital quantification of a species in an EWOD device includes inputting a sample volume and a diluent volume into the EWOD device; performing an electrowetting operation to generate a first sample droplet from the sample volume; performing an amplification process on the first sample droplet and measuring a turn-on value for the sample droplet; comparing the measured turn-on value to a target turn-on value for digital quantification; calculating a dilution factor based on the comparison of the measured and target turn-on values; performing an electrowetting operation to extract a second sample droplet from the sample volume; performing an electrowetting operation to dilute the second sample droplet with the diluent volume by the dilution factor to form a diluted second sample droplet; and performing a digital quantification on the diluted second sample droplet to quantify an initial concentration of the species in the sample volume.

Abstract: The present application relate to crystalline azide compound of formula (II) which is used as an intermediate for the preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof. The present application also covers purification process of azide compound of formula (II) and its further conversion to eribulin or a pharmaceutically acceptable salts thereof.

Abstract: The present application relate to a purification process for preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof having less than 0.15% or substantially free or free from one or more impurities. The present application also provide acid addition salts of eribulin and process for preparation thereof.

Abstract: A microfluidic control system for controlling an EWOD device has an enhanced thermal control system for generating a temperature profile within an EWOD device that is inserted into the microfluidic control system. The microfluidic control system includes a housing that defines an aperture for receiving an EWOD device; an active heating component located within the housing at a base of the aperture; and a lid attached to the housing that is moveable between a closed position and an open position, the lid including a thermal control component. When the lid is in the closed position, the thermal control component is positioned at the aperture and aligned oppositely from the active heating component. The active heating component may include a plurality of independently controllable individual heating elements, and the thermal control component may include a respective plurality of individual thermal control elements.

Abstract: An active matrix electro-wetting on dielectric (AM-EWOD) device has an optically black array element structure to enhance optical detection of constituents within a liquid droplet. The AM-EWOD device includes a thin film transistor (TFT) substrate assembly having a hydrophobic layer; thin film electronics having a plurality of array elements arranged in an array of rows and columns, each of the array elements including an array element electrode and a TFT device; and an optically black material disposed between a plane of the TFT device and the hydrophobic layer. The TFT substrate assembly further includes a planarization structure that includes a component having the optically black material. The planarization structure has a planarization component disposed between the TFT device and the array element electrode, and an ionic barrier disposed between the array element electrode and the hydrophobic coating. The planarization component or the ionic barrier includes the optically black material.

Abstract: A microfluidic system is configured for enhanced temperature control by combining spatial and temporal temperature control. The microfluidic system includes an electro-wetting on dielectric (EWOD) device comprising an element array configured to receive one or more liquid droplets, the element array comprising a plurality of individual array elements; a control system configured to control actuation voltages applied to the element array to perform manipulation operations of the liquid droplets; and a plurality of thermal control elements located at different spatial locations along the EWOD device, at least one of the thermal control elements being variable in temperature with respect to time. The control system includes a thermal control unit configured to control temperatures of the thermal control elements to generate a plurality of thermal zones located at different spatial locations along the EWOD device, at least one of the thermal zones being variable in temperature with respect to time.

Abstract: A golf swing training device for improving the accuracy, club head speed and power of a user's swing can be customized to fit the various abilities and sizes of individual golfers. The device guides a user through the proper swing and by repeating the proper swing, the user can enhance his or her muscle memory. The golf swing training device includes a shuttle moveably mounted on an adjustably supported ring and a club moveably supported by the shuttle.

Abstract: An electrowetting on dielectric (EWOD) device and a related method of performing a digital biological assay in an EWOD device are described.

Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.