Abstract: Systems for processing articles are essential for semiconductor fabrication. These systems employ a variety of apparatuses for controlling flow. In one implementation, an apparatus for controlling flow may utilize a body having a flow path extending from an inlet to an outlet. A valve, a flow restrictor, and a pressure sensor are operably coupled to the flow path. The valve incorporates first and second actuators which enable control of mass flow rates of fluid flowing through the flow path.

Abstract: A delivery system for delivering, adjusting, and/or recapturing a stent-valve includes an inner shaft and an expandable stent-valve coupled to the inner shaft. The stent-valve has an upper portion, a lower portion, and a valve. The delivery system also includes a distal sheath disposed over at least the lower portion, a proximal sheath disposed over at least the upper portion, and at least one cinching member coupled to the stent-valve and extending through one of the inner shaft, the distal sheath, or the proximal sheath. The upper and lower portions of the stent-valve are configured to move to an expanded configuration when the proximal and distal sheaths are withdrawn, respectively. After at least a portion of the stent-valve has been moved to the expanded configuration, the at least one cinching member is configured to at least partially radially compress at least a portion of the stent-valve.

Abstract: Processing O-rings in an automated mass production system includes advancing an O-ring retainer toward a loading position in alignment with an output end of a feed device, discharging a leading O-ring from the output end in electronic synchronization with advancement of the O-ring retainer to the loading position to initiate loading of the O-ring into the retainer prior to the retainer arriving at the loading position, after loading the O-ring into the retainer, advancing the retainer away from the loading position toward an unloading position, and moving an end effector in electronic synchronization with advancement of the retainer to the unloading position to synchronize arrival of the retainer at the unloading position with arrival of the end effector at a pick-up position in alignment with the O-ring at the unloading position for pick up of the O-ring by the end effector.

Abstract: Methods and systems for depth-based foveated rendering in a display system are disclosed. The display system may be an augmented reality display system configured to provide virtual content on a plurality of depth planes using different wavefront divergence. Some embodiments include monitoring eye orientations of a user of the display system. A fixation point can be determined based on the eye orientations, the fixation point representing a three-dimensional location with respect to a field of view. Location information of virtual object(s) to present is obtained, with the location information including three-dimensional position(s) of the virtual object(s). A resolution of the virtual object(s) can be adjusted based on a proximity of the location(s) of the virtual object(s) to the fixation point. The virtual object(s) are presented by the display system according to the adjusted resolution(s).

Abstract: The present disclosure provides a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Abstract: A method includes determining a cluster reliability of a computing cluster including a maximum computing capacity and representative of a reliability of the computing cluster when utilizing an entirety of the maximum computing capacity. The operations include receiving a provisioning request of the computing cluster including a threshold reliability of the computing cluster. In response to the provisioning request, determining, using the cluster reliability, a reserved computing capacity of the computing cluster based on the threshold reliability. The reserved computing capacity is less than the maximum computing capacity. Based on the reserved computing capacity and the maximum computing capacity, the operations include determining an unreserved computing capacity of the computing cluster. The operations include provisioning the computing cluster for execution of a user workload. The user workload executes on the unreserved computing capacity.

Abstract: A cover for providing protection to a bus bar used to interconnect cells of a battery of an electric vehicle, and method of construction thereof, is provided. The cover includes an impervious layer, an adhesive layer, and a fabric wall sandwiched between the impervious layer and the adhesive layer. The adhesive layer is provided to facilitate quick and easy attachment of the cover to a desired portion of the bus bar, wherein the cover can be shaped to cover any desired area of the bus bar in a conforming fit about the selected portion or entirety of the bus bar.

Abstract: The present disclosure provides a full inductor core configured for use with a power converter of an energy management system. For example, the full inductor core comprises a first planar inductor comprising a first inner core and a first outer core and a second planar inductor disposed on top of the first planar inductor and comprising a second inner core and a second outer core. The first inner core and first outer core and the second inner core and second outer core each have a sawtooth configuration that allows the full inductor core to be tuned during assembly of the full inductor core.

Abstract: A computer system may provide a plurality of load records for presentation in a user interface provided at a first plurality of user devices. The user interface may enable searching for a plurality of loads represented by the plurality of load records. The computer system may also determine, for a load record of the plurality of load records and based at least in part on inputting contextual information into a predictive model, an acceptance prediction indicating a probability that a load record of the plurality of load records will be accepted by a user. The computer system may also provide at least a portion of the plurality of load records for presentation in the user interface provided at a second plurality of user devices associated with a second plurality of users. The portion of the plurality of load records may include the load record including an updated value of an attribute of the load record that is dependent on the acceptance prediction.

Abstract: One challenge for middle-mile route planning is that the set of loads changes significantly between daily planning and execution. Systems and methods are provided for optimizing a transportation plan for a transportation network based on these load changes. The disclosed system re-optimizes a solution by starting from a previously existing plan and previously generated columns (e.g., candidate routes). The disclosed techniques significantly improve the compute time of the system to generate transportation plans that are optimized accordingly to an optimization parameter. The system takes into account the current execution status associated with a given entry of the plan to determine whether the entry should be re-optimized. Entries corresponding to tours that have already commenced, may be at least partially ignored for re-optimization consideration. The disclosed techniques enable state-aware, adaptive re-optimization for even tours that are in-progress or have been tendered.

Abstract: Techniques for planning resources using block and route information are described. In an example, a computing system determines a demand for item transportation expected during a planning horizon. The computing system determines information about a pre-planned transportation resource available during the planning horizon and costs associated with the pre-planned transportation resource. The computing system uses an optimization model to determine a block having a time length, a tour to transport, during the block, a first portion of the demand using the pre-planned transportation resource, and a second portion of the demand to be transported using an on-demand transportation resource. The computing system indicates, to a first computing device of the pre-planned transportation resource, an assignment of the block to the pre-planned transportation resource.

Abstract: Techniques for generating an item transmission portal are described herein. First information for a plurality of carriers may be maintained which includes a capacity for each carrier. Historical capacity requirements for geographic locations may be maintained. For each geographic location a forecast of future capacity requirements, for each week of a plurality of weeks, may be generated based on the historical capacity requirements. A plurality of documents may be generated for each geographic location based on the forecast and the first information. A value may be determined for each document based on a time and capacity commitment for each document, the historical capacity requirements, and the forecast. A user interface may be generated that includes the plurality of documents and corresponding determined values. The user interface may be updated to reflect acceptance of a specific document by a carrier in response to input received via the user interface.

Abstract: Method of producing an activated clostridial neurotoxin. Composition comprising an activated clostridial neurotoxin. Method of treatment using a composition comprising an activated clostridial neurotoxin.

Abstract: A method of operating an EWOD device to employs a magnetic field to separate magnetically responsive particles from a polar liquid droplet. The method includes the steps of dispensing a liquid droplet onto an element array of the EWOD device, wherein the liquid droplet includes magnetically responsive particles; performing an electrowetting operation to move the liquid droplet along the element array to a location relative to a magnet element in proximity to that location of the EWOD device; operating the magnet element to apply a magnetic field to the liquid droplet, wherein at least a portion of the magnetically responsive particles aggregate within the liquid droplet in response to the magnetic field; and separating the aggregated magnetically responsive particles from the liquid droplet with the magnetic field, wherein the aggregated magnetically responsive particles move in response to the magnetic field to a location on the element array in proximity to the magnet element.

Abstract: The present disclosure relates to comparisons of data over time and generating recommendations to create such comparisons. A visualization in an analytics application may include a plurality of data points and a user may select of one or more of the data points to configure the visualization. If the context of the visualization is based on time, the software may determine whether the one or more selected data points includes the current time period. If so, comparisons of the data over time may be included in the visualization and creation of these comparisons may be recommended to the user. One or more data comparisons may be determined by comparing each of the one or more selected data points to a corresponding data point in a previous time period. An updated visualization including the selected data points and the data comparisons may be provided.

Abstract: A microfluidic control system for controlling an EWOD device has an enhanced thermal control system for generating a temperature profile within an EWOD device that is inserted into the microfluidic control system. The microfluidic control system includes a housing that defines an aperture for receiving an EWOD device; an active heating component located within the housing at a base of the aperture; and a lid attached to the housing that is moveable between a closed position and an open position, the lid including a thermal control component. When the lid is in the closed position, the thermal control component is positioned at the aperture and aligned oppositely from the active heating component. The active heating component may include a plurality of independently controllable individual heating elements, and the thermal control component may include a respective plurality of individual thermal control elements.

Abstract: An EWOD device and a related method of performing a digital biological assay are described that employs two volume measurements for enhanced assay determination. The method includes partitioning a sample reservoir and measuring the volume of each partition; initiating a biological assay wherein the biological assay includes measuring a partition property and a volume of each partition in real time as part of determining a concentration of the product substance in each partition based on the measured partition property and volume; and categorizing the partitions by a number of biological entities contained in each partition from which the number of biological entities may be calculated, which in turn may be used to calculate the total number of biological entities or concentration in the sample reservoir. The method further may include an enhanced partitioning process that minimizes variation in the volume of the partitions.

Abstract: A method of digital quantification of a species in an EWOD device includes inputting a sample volume and a diluent volume into the EWOD device; performing an electrowetting operation to generate a first sample droplet from the sample volume; performing an amplification process on the first sample droplet and measuring a turn-on value for the sample droplet; comparing the measured turn-on value to a target turn-on value for digital quantification; calculating a dilution factor based on the comparison of the measured and target turn-on values; performing an electrowetting operation to extract a second sample droplet from the sample volume; performing an electrowetting operation to dilute the second sample droplet with the diluent volume by the dilution factor to form a diluted second sample droplet; and performing a digital quantification on the diluted second sample droplet to quantify an initial concentration of the species in the sample volume.

Abstract: The present application relate to crystalline azide compound of formula (II) which is used as an intermediate for the preparation of halichondrin B analogues such as eribulin or pharmaceutically acceptable salts thereof. The present application also covers purification process of azide compound of formula (II) and its further conversion to eribulin or a pharmaceutically acceptable salts thereof.