Abstract: A system and method of maneuvering a vehicle-trailer unit in reverse travel uses at least one sensor generating output information representative of the relative position between the vehicle rear and the trailer front. An electronic processing unit compares the measured quantity with a reference value and determines from the comparison whether the trailer deviates from a straight alignment with the vehicle. If the trailer is not aligned with the vehicle, the system can interfere with the vehicle's steering system, the trailer's brake system, or both. The sensor can be a distance sensor or a camera, and the quantity can be a distance or a marker position. As a reference value for comparison, the method can use a stored value or previously or simultaneously measured values. The method can be activated automatically or by a switch operated by the vehicle driver.

Abstract: A system and method of maneuvering a vehicle-trailer unit in reverse travel uses at least one sensor generating output information representative of the a relative position between the vehicle rear and the trailer front. An electronic processing unit compares the measured quantity with a reference value and determines from the comparison whether the trailer deviates from a straight alignment with the vehicle. If the trailer is not aligned with the vehicle, the system can interfere with the vehicle's steering system, the trailer's brake system, or both. The sensor can be a distance sensor or a camera, and the quantity can be a distance or a marker position. As a reference value for comparison, the method can use a stored value or previously or simultaneously measured values. The method can be activated automatically or by a switch operated by the vehicle driver.

Abstract: A water purifier includes a first crystallization chamber and a second crystallization chamber that each receives a supply of input water; wherein each of the first and second crystallization chambers is a freeze/thaw chamber in which water is alternately frozen and thawed. A refrigerant circuit alternately supplies cold refrigerant to freeze the input water in one of the crystallization chambers, and supplies heated refrigerant to the other of the crystallization chambers to thaw the purified water. The first and second crystallization chambers operate concurrently and out-of-phase whereby heat recovered from freezing in one of the crystallization chambers is transferred by the refrigerant circuit for use in thawing in the other of the crystallization chambers.

Abstract: Use of a therapeutic molecule, for the treatment of specific pain conditions, wherein the therapeutic molecule is a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment can cleave a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that can bind to a Binding Site on the nociceptive sensory afferent, which Binding Site can undergo endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and a translation domain that can translocate the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent.

Abstract: A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide, is possible and the polypeptide can be incorporated into vaccines and toxin assays.

Abstract: The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on the target cell, which Binding Site is capable of undergoing endocytosis to be incorporated into an endocome within the target cell; a protease cleaving site at which site the fusion protein is cleavable by the protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the Targeting Moiety; and the translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the target cell.

Abstract: A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a dynorphin Targeting Moiety that is capable of binding to a Binding Site on the nociceptive sensory afferent, which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the nociceptive sensory afferent; a protease cleavage site at which site the fusion protein is cleavable by a protease, wherein the protease cleavage site is located between the non-cytotoxic protease or fragment thereof and the dynorphin Targeting Moiety; and a translocation domain that is capable of translocating the protease or protease fragment from within an endosome, across the endosomal membrane and into the cytosol of the nociceptive sensory afferent.

Abstract: The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumour cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptor a melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalised and inhibits secretion from said tumour cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract: The present invention relates to polypeptides for use in suppressing cancer and cancer disorders. The treatment employs use of a non-cytotoxic protease, which is targeted to the cancer cell, and, when so delivered, the protease is internalised and inhibits secretion from the cancer cell.

Abstract: The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract: The present invention relates to a method for suppressing neuroendocrine disease. The therapy employs use of a non-cytotoxic protease, which is targeted to a neuroendocrine tumor cell, preferably via a somatostatin or cortistatin receptor, a GHRH receptor, a ghrelin receptor, a bombesin receptor, a urotensin receptor a melanin-concentrating hormone receptor 1; a KiSS-1 receptor or a prolactin-releasing peptide receptor. When so delivered, the protease is internalized and inhibits secretion from said tumor cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

Abstract: A method for controlling a heat recovery device in an internal combustion engine, in particular, for a motor vehicle. The heat recovery device is provided with a circuit for a working medium having an evaporator of an expansion machine that is arranged in an exhaust gas flow path of the internal combustion engine, a condensor, an expansion tank, and a feed pump. The working temperature of the working medium is controlled by varying the mass flow of the working fluid as a function of at least one operating parameter. A setpoint value of the working medium mass flow of an exhaust gas flow path of an exhaust gas tract and/or an exhaust gas recirculation line is calculated on the basis of a base setpoint value for the working medium mass flow. The base setpoint value for the working medium mass flow is at least a function of the exhaust gas temperature, preferably upstream of the evaporator, and of the exhaust gas mass flow in the exhaust gas flow path.

Abstract: An apparatus extracts water from the air using a single circuit of gas containing a compressor, a cooling element, a heat exchanger and an ion source, where a single stream of air is used to provide water and to pre-cool the inlet air.

Abstract: The system for installing shower walls includes a pressure transfer member for urging a shower wall against a back up support during bonding of the shower wall to the support. An adjustable force development device engages the pressure transfer member to force the pressure transfer member against the shower wall. A support member engages the pressure transfer member when the force development device exerts a predetermined force against the shower wall. A fixation device holds the support member to maintain the pressure transfer position of the pressure transfer member. The fixation device includes a cam that moves a shower wall into a tight corner fit with an adjacent shower wall.

Abstract: A composite material comprises magnetic particles dispersed in electrically insulating material. The magnetic particles have an aspect ratio greater than 1 (preferably greater than 10) and a concentration sufficiently high to produce negative permeability. The magnetic particles may be magnetic flakes of reduced carbonyl iron of average diameter 50 ?m, average thickness 1 ?m and aspect ratio 50, the magnetic flakes being at least 25% by volume of the composite material. The magnetic flakes may be aligned to produce enhanced permeability. The electrically insulating material may be paraffin wax, particulate PTFE, or another polymer. To control permittivity, the composite material may include an electrically conducting component such as graphite or conductive coatings upon the magnetic flakes.

Abstract: An end effector assembly for use with an instrument for sealing vessels and cutting vessels includes a pair of opposing first and second jaw members which are movable relative to one another from a first spaced apart position to a second position for grasping tissue therebetween. Each jaw member includes an electrically conductive tissue contacting surface connected to an electrosurgical energy source. At least one of the jaw members includes an electrically conductive cutting element disposed within an insulator defined in the jaw member. At least one channel is included in the insulator which is configured to deliver fluid between the jaw members.

Abstract: A system for the structural monitoring of blades 1 on a wind turbine. Each blade 1 has respective optical fiber bragg grating sensors 5. The system has a number of input connectors, which connect to the strain sensors 5 of respective blades 1. A single output connector connects to a data processing device 3 which processes signals from the strain sensors 5. The input connectors each have a signal path to the output connector that is different in length to the signal path from the other input connectors, such that signals from a given blade 1 can be identified at the data processing device 3 by the time of arrival of the signals. The system has the advantage that the each of the blades 1, including the sensors attached to it or embedded within it can be identical and therefore interchangeable.