Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.

Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.

Abstract: A construction set comprises a plurality of elements mutually co-operable to produce at least one assembly, wherein the elements comprise a plurality of connectors (100, 100?) each comprising a substantially cylindrical body and a hollow base, the body being provided with a radially extending cylindrical projection (130?) and the base with at least one groove (131?) and the projection and the groove being shaped to permit assembly of two such connectors (100, 100?) in mutually orthogonal relationship by engagement of the projection of one of those connectors in the at least one groove of the other one of those connectors.

Abstract: A method for growing organically derived building materials in the form of a moldable substrate that can be engineered to serve a wide range of manufacturing and construction applications is presented. In particular, the embodiments consider a plurality of fungal molded shapes preferably grown from fungal inoculum and mechanically compressed at least once during the growing process as well as integration of structure support members to the fungal structure. The present invention provides a fungal substrate which could be molded, and easily and cheaply preprocessed to precise geometric specifications. The organically derived building materials also incorporate layers of structural reinforcements to improve load bearing and other structural capacities.

Abstract: A test device, including: a compartment defining an environment and comprising a specimen region; an indicator medium disposed in the compartment; a separation medium disposed in the compartment between the specimen region and the indicator medium; an active ingredient adjacent the specimen region; and a color indicator disposed on the indicator medium and responsive a chemical compound produced by a reaction involving the active ingredient by changing from a first color to a second color. The separation medium is configured to permit fluid communication directly between the environment and a side of the indicator medium proximate the separation medium when the separation medium and the indicator medium abut each other.

Abstract: A harvester for brassicas, the harvester being movable along a plant row and comprising an endless conveyor orientated in the direction of the plant row, the conveyor being of generally tubular form defined by opposed rows of arcuate conveyor fingers movable from an open condition in which free ends of the opposed fingers are spaced so as to define a generally tubular configuration which is open at one side to a closed condition in which the free ends of the opposed fingers are adjacent to define a generally closed tubular configuration, the conveyor having an upper run and a lower run, the conveyor being configured at its forward end portion so that the fingers are in their open condition during transition from the upper run to the lower run and move downwardly onto a plant to be harvested so as to move foliage away from the plant head and to allow the plant head to enter the interior of the conveyor through the open side, with the fingers then moving to a closed condition to thereby capture the plant head w

Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.

Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.

Abstract: A harvester for brassicas, the harvester being movable along a plant row and comprising an endless conveyor orientated in the direction of the plant row, the conveyor being of generally tubular form defined by opposed rows of arcuate conveyor fingers movable from an open condition in which free ends of the opposed fingers are spaced so as to define a generally tubular configuration which is open at one side to a closed condition in which the free ends of the opposed fingers are adjacent to define a generally closed tubular configuration, the conveyor having an upper run and a lower run, the conveyor being configured at its forward end portion so that the fingers are in their open condition during transition from the upper run to the lower run and move downwardly onto a plant to be harvested so as to move foliage away from the plant head and to allow the plant head to enter the interior of the conveyor through the open side, with the fingers then moving to a closed condition to thereby capture the plant head w

Abstract: An adaptor for a line trimmer is disclosed including a mounting for mounting the adaptor to a line trimmer; and a support for maintaining the head of the line trimmer in spaced relationship to a grassy ground surface and allowing movement of the adaptor across the ground surface to thereby mow the grass by way of the head of the line trimmer.

Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.

Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.

Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.

Abstract: A safety apparatus includes a first member (28) defining a profiled channel (30) and adapted to be coupled to a frame (10) of a closure assembly, and a second member (38) defining a profiled portion (44) and adapted to be coupled to a closure device (12), wherein said profiled portion (44) is adapted to be received within the profiled channel (30) and to rotate therein when the closure device (12) is pivoted relative to the frame (10) to open and close an aperture. In one disclosed embodiment the second member (38) is a pivoting member adapted to be pivotally mounted on the frame (10) of the closure assembly via a pivot assembly (82), wherein said pivoting member is coupled to the closure device (12), such that said closure device (12) is pivotally mounted on the frame (10) via said pivoting member, said pivoting assembly (82) comprising a pivot shaft (40) adapted to extend between the pivoting member and frame (10) and adapted to be retracted into at least one of the pivoting member and frame (10).

Abstract: Anti-Lewis Y antibodies are described. Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Specifically, monomeric calicheamicin derivative/anti-Lewis Y antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.

Abstract: An outsole unit for an item of footwear comprises a base layer of a flexible material having fibres extending from one surface, for example a napped leather such as pigskin suede or a textile material, and one or more lugs of thermoplastic polyurethane (TPU) moulded directly to the fibrous surface so as to form a tread. Multiple lugs may form a regular array separated by grooves, and may be connected solely by the base layer, by a skin of TPU extending across the base layer or by narrow connecting elements of TPU. An upper of an item of footwear may comprise a backing of suede leather with a grid of strips of TPU moulded to its napped surface. An item of footwear may comprise the outsole unit of the invention, the upper of the invention, or both.

Abstract: A boot (1) or other item of footwear is made up of a rubber sole unit (2) mounted to an upper comprising both leather and rubber components, for example a foot piece (3) of rubber and a shaft piece (4) of leather having a napped outer surface, such as suede, particularly pigskin suede. The boot (1) is assembled with an edge of the rubber foot piece (3) overlapping the outer surface of the leather shaft piece (4), and a rubber tape (11) binding the edges (13) of the shaft piece (4) together. The whole boot (1) is then vulcanised, bonding the leather and rubber components sealingly together. The boot (1) or other item of footwear is attractive, durable and waterproof.

Abstract: A method of determining an operating water temperature for a boiling water heater includes the following steps: (a) adding water to a tank to a predetermined level; (b) heating the water in the tank to approximately 95 degrees Celsius; (c) applying sufficient heat to the water in the tanks so as to cause boiling of the water in the tank within a predetermined first period of time; (d) measuring the boiling water temperature of the water in the tank; and (e) subtracting a predetermined temperature from the boiling water temperature measured in step (d) to arrive at the operating water temperature.

Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.