Abstract: Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

Abstract: Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

Abstract: The present invention provides compounds of formula I useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

Abstract: Aspects described herein generally relate to methods of making a phosphono paraffin comprising forming a reaction mixture by mixing a haloparaffin, a phosphite, and sodium iodide. Methods comprise heating the reaction mixture to form the phosphono paraffin. Aspects described herein further relate to a phosphono paraffin represented by formula (I): wherein each instance of R1 is independently —H or wherein each instance of R2 and R3 is independently linear or branched C1-20 alkyl, C1-20 cycloalkyl, or aryl; the number of instances where R1 is of formula (I) is between about 2 and about 8; and n is an integer between 4 and 22.

Abstract: Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

Abstract: Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

Abstract: Aspects described herein generally relate to methods of making a phosphono paraffin comprising forming a reaction mixture by mixing a haloparaffin, a phosphite, and sodium iodide. Methods comprise heating the reaction mixture to form the phosphono paraffin. Aspects described herein further relate to a phosphono paraffin represented by formula (I): wherein each instance of R1 is independently —H or wherein each instance of R2 and R3 is independently linear or branched C1-20 alkyl, C1-20 cycloalkyl, or aryl; the number of instances where R1 is of formula (I) is between about 2 and about 8; and n is an integer between 4 and 22.

Abstract: The present disclosure relates to polysiloxanes, processes for preparing polysiloxanes, and hydraulic fluids comprising polysiloxanes. This disclosure also relates to hydraulic fluids comprising one or more polysiloxane compounds and diphosphonate compounds, and to the use of diphosphonate compounds in hydraulic fluids or as additives or components in various compositions, for example to provide fire retardant properties to a fluid or composition. This disclosure also relates to use of the compositions as hydraulic fluids, which may be used in various machines, vehicles and craft, including aircraft.

Abstract: The present invention provides compounds of formula I useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

Abstract: A system for generating an optical frequency standard is described. The system is based on a two-color approach and includes a first laser source that generates a first laser output at a first frequency and a second laser source that generates a second laser output at a second frequency corresponding. The first and second laser outputs are then respectively input into first and second harmonic generators to form frequency-doubled first and second laser outputs. The system also includes a two-color stabilization arrangement to stabilize the sum of the frequencies generated by first and second laser sources, including, for example, an interaction region incorporating a laser active material. The interaction region can be a gas reference cell and the laser active material can be Rubidium (in vapor form) having a two-photon transition.

Abstract: Systems and techniques are disclosed for decoupling a wearable sensor's location on a user from the body movements desired to be measured by the sensor. Sensor data can be dynamically analyzed to determine a reference event (e.g., a static pose), which can be used to generate or update a transformation parameter (e.g., a quaternion or a rotational matrix). The transformation parameter can be applied to sensor data to transform the sensor data from the sensor's frame of reference to a global frame of reference. Once transformed, the movement data in the global frame can be analyzed to identify sensor-location-agnostic biomechanical features (e.g., body movements or movement trends), which can be further analyzed to identify probable or potential diagnoses correlated with the identified biomechanical features.

Abstract: A system for generating an optical frequency standard is described. The system comprises a first laser source for generating a first laser output at a first frequency, a first second harmonic generator receiving as an input the first laser output to generate a frequency-doubled first laser output at a doubled first frequency, a second laser source for generating a second laser output at a second frequency different from the first frequency and a second harmonic generator receiving as an input the second laser output to form a frequency-doubled second laser output at a doubled second frequency.

Abstract: Aspects described herein generally relate to methods of making a phosphono paraffin comprising forming a reaction mixture by mixing a haloparaffin, a phosphite, and sodium iodide. Methods comprise heating the reaction mixture to form the phosphono paraffin. Aspects described herein further relate to a phosphono paraffin represented by formula (I): wherein each instance of R1 is independently —H or wherein each instance of R2 and R3 is independently linear or branched C1-20 alkyl, C1-20 cycloalkyl, or aryl; the number of instances where R1 is of formula (I) is between about 2 and about 8; and n is an integer between 4 and 22.

Abstract: Aspects described herein generally relate to methods of making a phosphono paraffin comprising forming a reaction mixture by mixing a haloparaffin, a phosphite, and sodium iodide. Methods comprise heating the reaction mixture to form the phosphono paraffin. Aspects described herein further relate to a phosphono paraffin represented by formula (I): wherein each instance of R1 is independently —H wherein each instance of R2 and R3 is independently linear or branched C1-20 alkyl, C1-20 cycloalkyl, or aryl; the number of instances where R1 is of formula (I) is between about 2 and about 8; and n is an integer between 4 and 22.

Abstract: A pump assembly for a dental cleaning appliance includes a fluid chamber, a piston, and a drive. Magnets, connected respectively to the piston and the drive, enable the drive to couple to the piston and move it within the fluid chamber to draw fluid into the fluid chamber. A stop prevents the piston from being pulled beyond a stop position so that through continued actuation of the drive the magnets separate to allow a spring to push the piston away from the stop position to urge a burst of fluid from the fluid chamber.

Abstract: Minimally invasive systems and methods are described for measuring pulmonary circulation information from the pulmonary arteries. A transbronchial Doppler ultrasound catheter is advanced through the airways and in the vicinity of the pulmonary artery. Doppler ultrasound energy is sent through the airway wall and across the pulmonary artery to obtain velocity information of blood flowing through the artery. The velocity information is used to compute pulmonary circulation information including but not limited to flowrate.

Abstract: A large format array is described having a series of smaller arrays daisy chained together to form the larger array. The smaller arrays are mounted on a base plate that may be of a non planar configuration. The daisy chaining together of the smaller arrays enables a smaller number of connections to be made to the external interface via connections.

Abstract: Methods are disclosed for filling a filter cartridge canister. Flow through an exit plenum and a filter screen of the canister is initially blocked, a sorbent inlet of the canister is open, and a ring of the canister is open. Flow is then initiated through the inlet and ring so sorbent particles and fluid flow into the canister. A pressure differential is provided between the inlet and the ring to enhance filling. The exit plenum is opened to impart an even fluid flow across a sorbent stratum. Flow through the ring is stopped, and sorbent particles continue to be added via the inlet until the cavity is filled. The filter screen is then compressed, the sorbent inlet is sealed and the filter screen is fixed to a compressed position while flow is maintained through the exit plenum.

Abstract: Apparatus (100) adapted to provide an indication of an angular position of an input member (106) over multiple turns includes at least two rotatable members (104A-104D) configured, in use, to rotate in accordance with rotation of an input member (106), and at least one sensing device (114A) configured to measure and output an angular position of at least one of the rotatable members. The rotatable members are configured to rotate simultaneously but at different rates. The apparatus further includes a device (114) configured to use the angular position measurements from the at least one sensing device to produce an cation of an angular position of the input member over multiple turns.

Abstract: The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1-3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn . . . S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.