Abstract: The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.

Abstract: An amusement ride system includes: a shooting device adapted to shoot a projectile; an aiming facility operable by a user to aim the shooting device; and a triggering device operable by the user to fire the shooting device. The user rides the vehicle, aims the shooting device, and fires the device to shoot the projectile. A method for a ride includes: providing a shooting device; providing a plurality of projectiles; and aiming and shooting the projectiles utilizing the shooting device.

Abstract: The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

Abstract: An amusement ride system includes: a shooting device adapted to shoot a projectile; an aiming facility operable by a user to aim the shooting device; and a triggering device operable by the user to fire the shooting device. The user rides the vehicle, aims the shooting device, and fires the device to shoot the projectile. A method for a ride includes: providing a shooting device; providing a plurality of projectiles; and aiming and shooting the projectiles utilizing the shooting device.

Abstract: The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.

Abstract: The invention relates to the isolation and use of a novel progenitor cell population from the lamina propria of the oral mucosa. The novel progenitor cell population is highly proliferative and can be differentiated into a range of cell lineages. Further, these novel progenitor cells possess immunomodulatory activity and so can be used in the allogeneic transfer of tissue or to help combat immune disorders.

Abstract: The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

Abstract: A method and apparatus are present for managing a transmission of photons. The number of parameters for transmitting the photons as a beam in a liquid are identified using a number of characteristics of the liquid to form a number of selected parameters. The photons are transmitted in the liquid as the beam to a target using the number of selected parameters to form the transmission of the photons.

Abstract: An end cap for an exhaust treatment device is disclosed. The end cap has a cylindrical housing with an axial direction, a radial direction substantially orthogonal to the axial direction, a first open end, and a second closed end opposing the first open end in the axial direction. The end cap also has an integral port member extending from an annular surface of the cylindrical housing. The integral port member has a central axis aligned in the radial direction, and an exterior surface of the integral port member tangentially connects to an exterior surface of the cylindrical housing.

Abstract: An amusement ride system includes: a shooting device adapted to shoot a projectile; an aiming facility operable by a user to aim the shooting device; and a triggering device operable by the user to fire the shooting device. The user rides the vehicle, aims the shooting device, and fires the device to shoot the projectile. A method for a ride includes: providing a shooting device; providing a plurality of projectiles; and aiming and shooting the projectiles utilizing the shooting device.

Abstract: An electric motor includes a stator and a rotor having a rotor shaft with a longitudinal axis. The rotor shaft has a locating groove formed substantially continuously around the rotor shaft. The locating groove has a base and a pair of opposing sidewalls. The base is arranged substantially parallel to the axis of rotation. The pair of opposing sidewalls extends from the base wall substantially perpendicular to the axis of rotation. The motor includes a thrust system mounted on the rotor shaft, and a locator disposed in the groove for locating the thrust system in a predetermined position along the rotor shaft.

Abstract: The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

Abstract: A method of testing a biological fluid for the presence of an infection. The method includes the steps of introducing a sample of biological fluid and a reagent including light amplifying compound into a reaction chamber, the light amplifying compound reacting with a substance present only in an infected sample to emit light, and immediately measuring the intensity of any light emitted from the sample.

Abstract: An end cap for an exhaust treatment device is disclosed. The end cap has a cylindrical housing with an axial direction, a radial direction substantially orthogonal to the axial direction, a first open end, and a second closed end opposing the first open end in the axial direction. The end cap also has an integral port member extending from an annular surface of the cylindrical housing. The integral port member has a central axis aligned in the radial direction, and an exterior surface of the integral port member tangentially connects to an exterior surface of the cylindrical housing.

Abstract: The present invention relates to a method of determining the microbial bioburden in a wound (in particular a diabetic ulcer) in a test subject, the method comprising the step of measuring the level of a cytokine in a wound sample, wherein a cytokine level lower than a reference level indicates a significant microbial bioburden in the wound (or a cytokine level higher than a reference level indicates an insignificant microbial bioburden in the wound). The invention provides methods of diagnosis, prognosis and treatment of wound infection, and devices and kits for use in such methods.

Abstract: The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I wherein each of the substituents is given the definition as set forth in the specification and claims, pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

Abstract: A messaging system for sending formatted pages combining pictures, text, hyperlinks and other web-style content between mobile telephony devices such as mobile telephones or PDAs within a network or community of users. The display of the messages on the mobile terminals is defined by means of command set which allows users to specify message content as occupying a certain percentage of the display screen of the destination device. The command set also includes functionality allowing hyper-links within a message to be displayable as a separate list of hyperlinks on operation of a soft key on the mobile device for ease of navigation.

Abstract: A gaming system simulates events in a casino table card wagering game where there has traditionally been a dealer, whether or not the dealer is an active player in the game. Two distinct video areas are preferably provided, one providing video images of a virtual dealer, and the second video display providing a simulation of a table top for player cards, and optionally also dealer cards. The players have individual play areas with player input, and these play areas have individual processing intelligence that communicates directly with at least one processor. Delivery order of cards is determined by actual shuffling or randomization of a physical deck of cards, reading the cards, then creating an electronic file of the order of the shuffled or randomized cards, then using an order of cards contained in the electronic file to deliver virtual cards to players, dealer and flop as needed.

Abstract: An indicator device adapted give a detectable signal when the antioxidant capacity of a sample of a mammalian wound fluid exceeds a predetermined minimum level which is characteristic of an infected wound. Also provided system for use in the diagnosis and treatment of wounds comprising the inventive diagnostic device and a wound dressing comprising at least one antimicrobial agent for selective application to infected wounds. Also provided are methods of diagnosis and treatment by means of the inventive device and system.