Patents by Inventor Philip Stewart

Philip Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETING ANABOLIC DRUGS FOR ACCELERATED FRACTURE REPAIR
    Publication number: 20210213135
    Abstract: Aspects of the disclosure include materials and methods for the targeted delivery of growth factors, and other compounds that stimulate bone growth and in some aspect bone healing. Some aspects of the disclosure include methods for synthesizing and testing these compounds. Some aspects of the invention include methods of using the compounds disclosed herein to treat bone fractures and bone defects.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 15, 2021
    Inventors: Philip Stewart Low, Stewart A. Low, Jeffery Jay Howard Nielsen
  • TARGETING ANABOLIC DRUGS FOR ACCELERATED FRACTURE REPAIR
    Publication number: 20210206820
    Abstract: Aspects of the disclosure include material and methods for the targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein. Aspects of the disclosure can be used to treat bone fractures and bone defects.
    Type: Application
    Filed: May 30, 2019
    Publication date: July 8, 2021
    Inventors: Philip Stewart Low, Stewart A. Low, Jeffery Jay Howard Nielsen, Mingding Wang
  • METHOD OF TREATING CANCER BY TARGETING MYELOID-DERIVED SUPPRESSOR CELLS
    Publication number: 20210170035
    Abstract: The invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker. More particularly, the invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target myeloid-derived suppressor cells.
    Type: Application
    Filed: February 3, 2021
    Publication date: June 10, 2021
    Inventors: Philip Stewart Low, Bingbing Wang
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20210077468
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: October 30, 2020
    Publication date: March 18, 2021
    Inventors: Philip Stewart Low, Sumith A. Kularatne
  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY
    Publication number: 20200405760
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: July 6, 2020
    Publication date: December 31, 2020
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE, Yingjuan J. LU, Christopher Paul LEAMON, Leroy W WHEELER
  • CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY
    Publication number: 20200384114
    Abstract: Conjugates are described herein where CCK2R targeting ligands are attached to an active moiety, such as therapeutic agent or an imaging agent, through a linker. The conjugates can be used in the detection, diagnosis, imaging and treatment of cancer.
    Type: Application
    Filed: July 29, 2020
    Publication date: December 10, 2020
    Inventors: Philip Stewart Low, Charity Wayua
  • Luteinizing hormone-releasing hormone receptor (LHRH-R) conjugates and uses thereof
    Patent number: 10821188
    Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: November 3, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Jyoti Roy
  • DELIVERY OF AGENTS TO INFLAMED TISSUES USING FOLATE-TARGETED LIPOSOMES
    Publication number: 20200297632
    Abstract: The invention described herein pertains to folate-receptor targeted agents comprising therapeutic agents useful for the treatment of inflammatory disease, including folate-receptor targeted liposomes (folate-targeted liposomes) containing entrapped therapeutic agents and folate-receptor targeted dendrimers conjugated to therapeutic agents (folate-targeted dendrimer conjugates), useful for the treatment of inflammatory disease, including auto-immune disease, as well as to folate-targeted liposomes containing entrapped imaging agents and dendrimer conjugates conjugated to imaging agents, for use in the diagnosis and monitoring of treatment in such disease.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 24, 2020
    Inventors: Philip Stewart LOW, Scott POH
  • PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
    Publication number: 20200283748
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Application
    Filed: December 23, 2019
    Publication date: September 10, 2020
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • CHEMICAL COMPOUNDS
    Publication number: 20200270210
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Inventors: Philip Stewart TURNBULL, Rodolfo Cadilla
  • FIBROBLAST ACTIVATION PROTEIN (FAP)-TARGETED IMAGING AND THERAPY
    Publication number: 20200237936
    Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for imaging cancer-associated fibroblasts (CAFs) in the tumor microenvironment of a patient. The present teachings relate generally to method of making conjugates comprising a fibroblast activation protein (FAP) inhibitor.
    Type: Application
    Filed: December 13, 2017
    Publication date: July 30, 2020
    Inventors: Philip Stewart LOW, Jyoti ROY
  • Chemical compounds
    Patent number: 10710963
    Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 14, 2020
    Assignee: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Philip Stewart Turnbull, Rodolfo Cadilla
  • Folate Receptor Binding Conjugates of Antifolates
    Publication number: 20200147072
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Application
    Filed: June 13, 2019
    Publication date: May 14, 2020
    Applicants: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • PSMA binding ligand-linker conjugates and methods for using
    Patent number: 10557128
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: March 24, 2018
    Date of Patent: February 11, 2020
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam, Youngsoon Kim, Sumith A. Kularatne
  • COMPOSITIONS AND METHODS FOR CAR T CELL THERAPY
    Publication number: 20200023009
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 23, 2020
    Inventors: Philip Stewart LOW, Haiyan CHU, Yong Gu LEE, Yingjuan J. LU, Christopher Paul LEAMON, Leroy W. WHEELER, II
  • LUTEINIZING HORMONE-RELEASING HORMONE RECEPTOR (LHRH-R) CONJUGATES AND USES THEREOF
    Publication number: 20190365904
    Abstract: The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.
    Type: Application
    Filed: December 13, 2017
    Publication date: December 5, 2019
    Inventors: Philip Stewart LOW, Jyoti ROY
  • LIGAND IONOPHORE CONJUGATES
    Publication number: 20190298843
    Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
    Type: Application
    Filed: May 16, 2019
    Publication date: October 3, 2019
    Inventors: Philip Stewart LOW, Andrea L. KASINSKI, Loganathan RANGASAMY, Venkatesh CHELVAM
  • Ligand ionophore conjugates
    Patent number: 10406238
    Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: September 10, 2019
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Venkatesh Chelvam
  • METHODS OF USE FOR CAR T CELLS
    Publication number: 20190255109
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Application
    Filed: January 22, 2019
    Publication date: August 22, 2019
    Inventors: Philip Stewart LOW, Haiyan CHU, Yingjuan June LU, Christopher Paul LEAMON, Leroy W. WHEELER, II, Michael C. JENSEN, James MATTHAEI
  • Folate receptor binding conjugates of antifolates
    Patent number: 10363250
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 30, 2019
    Assignees: Endocyte, Inc., Purdue Research Foundation
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low