Abstract: The invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker. More particularly, the invention described herein relates to methods for treating a cancer using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target myeloid-derived suppressor cells.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.

Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.

Abstract: To promote ease of use, as well as a reduction in bit error rates during extended data exchange between a coupled NFC tag/reader pair, signal strength is measured from a plurality of NFC tag antennas each positioned differently with respect to a common reader field, and differences in signal strength are used to determine an optimum positioning of the tag, or tag emulator, with respect to the reader. Alternative embodiments may include signal time of flight for determining orientation of the NFC antennas within the reader field. Information is generated by the tag, or tag emulator, and output by the tag, or tag emulator, such that a user may direct the positioning of the tag, or tag emulator, for improved communication with the reader.

Abstract: An electronic device that includes a sensor module, a measuring module and a near field communication (NFC) device. The sensor module receives an input signal. The measuring module measures the strength of the input signal and determines whether the input meets a predefined threshold. If the strength of the input signal meets the predefined threshold, the measuring module activates the NFC device. If the strength of the input signal does not meet the predefined threshold, the measuring module de-activates the NFC device.

Abstract: According to an embodiment, a testing system for a satellite payload includes a built-in testing component configured at a satellite, the built-in testing component comprising a built-in testing component input and a built-in testing component output, and a payload component configured at the satellite, the payload component comprising a payload component input communicatively connected to the built-in testing component output and a payload component output communicatively connected to the built-in testing component input, wherein the built-in testing component is configured to transmit a digital test signal from the built-in testing component output to the payload component input and receive a digital output signal at the built-in testing component input from the payload component output.

Abstract: The disclosed system and method seamlessly melds aspects of chat and email in one system. The disclosed system and method facilitates easy and frictionless real-time collaboration between Users, whether accessed via email, a web interface, or a chat client.

Abstract: The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor ? (FR-?) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-?.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.

Abstract: This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

Abstract: The disclosed system and method seamlessly melds aspects of chat and email in one system. The disclosed system and method facilitates easy and frictionless real-time collaboration between Users, whether accessed via email, a web interface, or a chat client.

Abstract: A near field communications (NFC) device is disclosed that is capable of optimizing a gain for received signals. Measurements are made of signals received from an NFC environment and are compared to one or more threshold hold values. Based on the comparison, it is determined whether the measurements indicate underamplification or overamplification. Depending on the results of the analysis, one or more components within the NFC device is adjusted to increase or decrease the gain, respectively. The measurements may be taken during an unloaded baseline state or during loading, and may be compared to previous measurements to estimate their accuracy.

Abstract: A wireless device includes a Near Field Communication (NFC) interface, a NFC antenna, ferrite shielding, NFC antenna tuning circuitry coupled to the NFC interface and to the NFC antenna, and processing circuitry. The processing circuitry receives temperature input from a temperature sensor that is indicative of a temperature of at least one of the NFC antenna or the ferrite shielding, determines at least one NFC antenna tuning setting based upon the temperature input and configures the NFC antenna tuning circuitry based upon the at least one NFC antenna tuning setting. The NFC antenna tuning circuitry may include a plurality of lumped circuit elements including at least one controllable capacitance or inductance. The temperature sensor may be stand alone, included with the NFC interface, included with a battery, included with the processor, included with another wireless interface of the wireless device, or included with another component of the wireless device.