Abstract: The invention discloses compounds of Formula (I), wherein A1, R1, R2, R3, R4, and n are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Abstract: Systems, methods and devices for the treatment of tissue are disclosed. A system includes an elongate tube with a distal portion. A treatment element is positioned on the elongate tube distal portion, the treatment element constructed and arranged to treat target tissue. In one embodiment, gastrointestinal tissue is modified for the treatment of diabetes.

Abstract: A surgical device for retraction of a body part is disclosed. The surgical device comprises an anchor at each end of the surgical device; an elongate body comprising a plurality of fenestrations along a body length wherein each fenestration is sized to receive at least part of one of the anchors; and a stopper preventing a tail end of the device being pulled through any of the plurality of fenestrations. The surgical device may also comprise additional features such as, the elongate body being sufficiently flexible to fold back or partly fold back on itself and the lead anchor and tail anchor being oriented in the same direction. Also provided is a method of manufacturing the surgical device; a method for inserting the surgical device; and a kit comprising the surgical device.

Abstract: A surfboard with a surfboard body (1) extending along a longitudinal direction (L) and having an upper surface and a bottom surface. An electrical battery pack (2) is removably positioned in an upper compartment accessible from the upper surface. An electrically driven water-jet configured to propel the surfboard is provided with electrical power from the electrical battery pack. The electrically driven water-jet is provided in a propulsion module (3) that is removably positioned in a lower compartment accessible from the lower surface. The upper compartment and the lower compartment partly overlaps each other as seen along the longitudinal direction (L).

Abstract: A system and method for sharing information on a network-based social platform is provided. An indication is received from a first user to share information regarding an item on a network-based social platform. The network-based social platform is a platform that allows the first user to communicative couple with other users of the network-based social platform. Profile information of the first user is accessed. A determination of whether the first user is authorized to share the information is made. Based on the first user being authorized, an identifier for the item is added to a list of recommended items that is accessible view the network-based social platform.

Abstract: A mask system for delivery of respiratory therapy to a patient includes a nares portion and a mouth portion and an inlet conduit connected to at least one of the nares portion and the mouth portion to deliver the pressurized, breathable gas. The mask system is adapted to selectively utilize the nares portion and/or the mouth portion in a first mode utilizing both the nares portion and the mouth portion, and in a second mode utilizing the nares portion and not utilizing the mouth portion.

Abstract: A method provides binaural sound to a person through electronic earphones. The binaural sound localizes to a sound localization point (SLP) in empty space that is away from but proximate to the person. When an event occurs, the binaural sound switches or changes to stereo sound, to mono sound, or to altered binaural sound.

Abstract: In some aspects, a flexible cable may comprise: a flexible strip with first and second parallel surfaces and first and second ends, said flexible strip being electrically insulating; a metal stripline within said flexible strip; first and second metallic grounding planes on said first and second surfaces, respectively; and a first circuit board mechanically attached to at least one of said first end of said flexible strip and said first and second metallic grounding planes at said first end, said first circuit board being mechanically stiff, said metal stripline being electrically connected to electrical circuitry on said first circuit board.

Abstract: A system and method for the transfer of cryogenic fluid fuel includes a nozzle positionable with respect to fuel tank inlet, e.g., of an unmanned aerial vehicle (UAV), a seal to seal the area where the nozzle and inlet are connected, a collapsible and expandable bellows providing an isolation volume where the fluid is transferred from the nozzle into the inlet; a vacuum is provided in the volume to avoid accumulation of fuel or other species in the volume.

Abstract: A computer implemented method of performing inference on a generative model, wherein the generative model in a probabilistic program form, said probabilistic program form defining variables and probabilistic relationships between variables, the method comprising: providing at least one of observations or interventions to the generative model; selecting an inference method, wherein the inference method is selected from one of: observational inference, interventional inference or counterfactual inference; performing the selected inference method using an approximate inference method on the generative model; and outputting a predicted outcome from the results of the inference; wherein approximate inference is performed by inputting an inference query and the model, observations, interventions and inference query are provided as independent parameters such that they can be iterated over and varied independently of each other.

Abstract: In one aspect, a system for controlled temporal extraction of ingredients of a pharmaceutical dosage form is disclosed, which comprises at least one reservoir for storing a fluid comprising a solvent, a cell having at least one inlet port in fluid communication with said reservoir for receiving a flow of the fluid from the reservoir and an outlet port through which fluid can exit the cell, where the cell is configured to receive a pharmaceutical dosage form. The system can further include an in-line heater disposed in proximity of the inlet port of the cell for heating the fluid to an elevated temperature prior to entry thereof into the cell, and a pump for causing fluid circulation between said reservoir and said cell.

Abstract: Systems, methods, and computer-readable media for automated detection of relative position among a plurality of wireless access points (WAPs) deployed in service area. An exemplary service area is the passenger cabin of a commercial airplane. The method can include transmitting a signal on a wireless channel at a fixed power level across the service area. Each WAP can measure a signal strength of the signal received from all other WAPs of the plurality of WAPs. The plurality of WAPs can share reports including signal strengths of the signal transmitted from all of the other WAPs. Each WAP can then form a matrix of measured signal strengths and measuring WAPs including the signal strength of signals transmitted by each WAP as received by all other WAPs as the measuring WAPs. The matrix can be used to determine a relative position of the plurality of WAPs based on the first matrix.

Abstract: Control system configured for sample tracking in an electron microscope environment registers a movement associated with a region of interest located within an active area of a sample under observation with an electron microscope. The registered movement includes at least one directional constituent. The region of interest is positioned within a field of view of the electron microscope. The control system directs an adjustment of the electron microscope control component to one or more of dynamically center and dynamically focus the view through the electron microscope of the region of interest. The adjustment comprises one or more of a magnitude element and a direction element.

Abstract: An apparatus and method for treating air. A housing can enclose a heating zone and an oxidizing zone positioned downstream of the heating zone with respect to a flow direction of the air being treated. A catalyst in the oxidizing zone oxidizes contaminants from the air, and an air mover positioned is configured to move air from an air inlet through the housing to an air outlet. An air treatment cycle can include an air cleaning mode at a high air flow and a self-cleaning mode at a lower air flow. A heater is operated during the self cleaning mode to oxidize contaminants that on the catalyst from the air cleaning mode.

Abstract: Embodiments of the present disclosure relate to systems and methods for the application of vaporized chemicals in the sterilization of medical products. For example, embodiments of the present disclosure may relate to systems and methods for the terminal sterilization of medical products using vaporized hydrogen peroxide (VHP). Embodiments of the present disclosure may relate to, e.g., systems and methods for the terminal sterilization of medical products, such as pre-filled syringes (PFS).

Abstract: The embodiments herein describe hybrid parallelism techniques where a mix of data and model parallelism techniques are used to split the workload of a layer across an array of processors. When configuring the array, the bandwidth of the processors in one direction may be greater than the bandwidth in the other direction. Each layer is characterized according to whether they are more feature heavy or weight heavy. Depending on this characterization, the workload of an NN layer can be assigned to the array using a hybrid parallelism technique rather than using solely the data parallelism technique or solely the model parallelism technique. For example, if an NN layer is more weight heavy than feature heavy, data parallelism is used in the direction with the greater bandwidth (to minimize the negative impact of weight reduction) while model parallelism is used in the direction with the smaller bandwidth.

Abstract: The present disclosure provides a transgenic corn comprising event MON87403 that exhibits increased grain yield. The disclosure also provides cells, plant parts, seeds, plants, commodity products related to the event, and DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a corn plant. The disclosure further provides methods for detecting the presence of said corn event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said corn event.

Abstract: An electronic device displays a graphical representation with a first appearance when sound from the graphical representation plays as mono sound or stereo sound. The electronic device displays the graphical representation with a second appearance when the sound from the graphical representation plays as binaural sound. The second appearance includes an indication that informs a user of the electronic device that the sound plays as the binaural sound.

Abstract: A write history buffer can prevent write disturb in memory, enabling a reduction in write disturb refresh rate and improvement in performance. A memory device can include circuitry to cause consecutive write commands to the same address to be spaced by an amount of time to reduce incidences of write disturb, and therefore reduce the required write disturb refresh rate and improve performance. In one example, a memory device receives multiple write commands to an address. In response to receipt of the multiple write commands, the first write command is sent to the memory and a timer is started. Subsequent write commands that are received after the first write command and before expiration of the timer are held in a buffer. After expiration of the timer, only the most recent of the subsequent write commands to the address is sent to the memory array.

Abstract: Embodiments disclosed herein include photodiodes and methods of forming such photodiodes. In an embodiment, a method of creating a photodiode, comprises disposing an absorber layer over a first contact, wherein the absorber layer comprises a first conductivity type, and disposing a semiconductor layer over the absorber, wherein the semiconductor layer has a second conductivity type that is opposite from the first conductivity type. In an embodiment, the method further comprises disposing a hole blocking layer over the semiconductor layer, wherein the hole blocking layer is formed with a reactive sputtering process with a processing gas that comprises oxygen, and disposing a second contact over the hole blocking layer.