Abstract: This disclosure describes a multi-junction laser diode with improved wavelength stability. The multi-junction laser diode is found in an edge emitting laser (EEL). The disclosed system and method are suited for improving the wavelength stability of multi-junction EEL without coupling the laser modes of the individual junctions and without using any external elements such as Fiber Bragg Gratings (FBR), Volume Bragg Gratings (VBG) or Thermoelectric Cooling (TEC).

Abstract: The present invention provides a method for designing of a piece of apparel in particular an upper of a shoe, comprising the steps of providing at least one first panel including a plurality of feature points in an essentially two-dimensional configuration, arranging the at least one first panel on a first reference body in a three-dimensional configuration representing the piece of apparel to be designed, generating a first mapping between the two-dimensional configuration of the at least one first panel and the three-dimensional configuration of the at least one first panel using the plurality of feature points and designing the piece of apparel using the first mapping.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.

Abstract: An elevator system includes at least one car and at least one counterweight. At least two support means having different physical properties are arranged between the at least one car and the at least one counterweight.

Abstract: A cascade arrangement and to a semiconductor module. The cascode arrangement includes: a substrate, a JFET, a MOSFET, and at least one sensor system. A drain terminal of the MOSFET is electrically connected to a source terminal of the JFET and a source terminal of the MOSFET is electrically connected to a gate terminal of the JFET. A first semiconductor layer in which the MOSFET is formed and a second semiconductor layer in which the JFET is formed, are situated stacked on top of one another via a connecting material. Both an electrical and a thermal coupling between the JFET and the MOSFET are implemented via the connecting material. The stacked semiconductor layers are situated on the substrate. The first semiconductor layer includes a first subarea in which the MOSFET is formed and at least one second subarea in which the at least one sensor system is formed.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: A drive train has a hydrodynamic retarder including a rotating bladed rotor and bladed stator, forming a working chamber for hydrodynamic transmission of power from rotor to stator, a power input feeding drive power to the retarder, and a synchronized separating clutch connected between power input and rotor. The clutch has two clutch halves, friction elements contacting each other and mechanical blocking elements. The friction elements equalize rotational speed between clutch halves, and the blocking elements form-lockingly connect the clutch halves. The clutch has an actuator displaceable along a displacement travel, over a first distance bringing the friction elements into mutual contact, and a second distance adjoining the first distance to synchronize the friction elements and rotational speed for locking with the blocking elements. At least one displacement sensor directly or indirectly detects displacement travel by the actuator and/or position of the actuator on the displacement travel.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A catching device for a traveling body in an elevator system and a method for unblocking the catching device include at least two retaining units that can be brought into a blocked state and into an unblocked state, the retaining units retaining the traveling body on a rail in the blocked state. The retaining units are connected to the traveling body such that each of the retaining units and the traveling body can be slid relative to each other within a limited sliding displacement. A first sliding displacement of a first of the retaining units is longer than a second sliding displacement of a second of the retaining units.

Abstract: A polymer having a backbone chain, wherein the backbone chain includes linear amide linkages and nitrogen-atom-containing heteromonocyclic moieties, wherein the backbone chain is free of peptide linkages or wherein the backbone chain has a proportion of peptide linkages of maximum 30%, based on a total number of the linear amide linkages of the backbone chain, and wherein the nitrogen-atom-containing heteromonocyclic moieties have a proportion of 5% by weight to 25% by weight, based on the total weight of the polymer, is provided. A product or article and the use of the polymer for manufacturing or producing the product or article are further provided.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: A bicycle battery device includes a bicycle frame tube such as a down tube. A battery is insertable in the longitudinal direction of the bicycle frame tube through a battery opening. An adjustment element is arranged between the battery and an inner contour of the bicycle frame tube to simplify the adjustment.

Abstract: The present disclosure relates to an injection device for administering of a dose of a medicament. The injection device includes a housing that configured to accommodates a cartridge filled with the medicament, a first component movable relative to the housing along the longitudinal direction between an initial position and a trigger position for dispensing of the dose of the medicament, a second component rotatable relative to the housing for at least one of setting of the dose or dispensing of the dose, a cavity provided in or formed by at least one of the first component and the second component, the cavity been sized to accommodate an electronic detector, and at least a first gasket fastened to one of the housing, the first component and the second component and configured to seal the cavity against ingress of impurities at least while the first component is in the initial position.

Abstract: An autonomous mobile outdoor ground treatment robot includes an at least upper-side outer contour and a display screen device. The at least upper-side outer contour includes a contour face in a plan view of the outdoor ground treatment robot. The display screen device comprises a display screen face. The size of the display screen face in plan view of the outdoor ground treatment robot is at least 5% of a size of the contour face.

Abstract: The present disclosure relates to a medicament delivery device comprising: a reservoir for medicament; a dispensing mechanism operable to dispense medicament from the reservoir, the dispensing mechanism comprising a sleeve configured to rotate during the dispensing of medicament and having a plurality of formations at an end of the sleeve; and a dosage measurement system comprising at least one mechanically actuated sensor configured such that, in use, rotation of the sleeve causes successive formations to engage the sensor such that the sensor detects rotation of the sleeve and a processor configured to determine a dosage dispensed from the medicament reservoir based on the detected rotation of the sleeve.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: An elevator system includes at least one car and at least one counterweight. At least two support means having different physical properties are arranged between the at least one car and the at least one counterweight.

Abstract: A solenoid valve, for controlling a brake pressure of a wheel brake of a slip-regulatable hydraulic brake system for a motor vehicle, includes a valve element, valve insert, valve seat, spring device, electromagnetic actuator, and armature. The valve element is longitudinally movably positioned at least partially in the valve insert, positioned between the armature and the valve seat, and configured to interact with the valve seat. The spring device, in an assembled position, has a force component acting on the valve element in an opening direction with respect to the valve seat. The electromagnetic actuator is configured to act on the valve element in a closing direction with respect to the valve seat. The valve element has a contact surface operatively connecting the valve element and armature, and configured such that a central axis of the valve element and the contact surface form a non-rectangular intersection angle.

Abstract: A drive train has a hydrodynamic retarder including a rotating bladed rotor and bladed stator, forming a working chamber for hydrodynamic transmission of power from rotor to stator, a power input feeding drive power to the retarder, and a synchronized separating clutch connected between power input and rotor. The clutch has two clutch halves, friction elements contacting each other and mechanical blocking elements. The friction elements equalize rotational speed between clutch halves, and the blocking elements form-lockingly connect the clutch halves. The clutch has an actuator displaceable along a displacement travel, over a first distance bringing the friction elements into mutual contact, and a second distance adjoining the first distance to synchronize the friction elements and rotational speed for locking with the blocking elements. At least one displacement sensor directly or indirectly detects displacement travel by the actuator and/or position of the actuator on the displacement travel.