Abstract: The present disclosure relates to a medicament delivery device comprising: a reservoir for medicament; a dispensing mechanism operable to dispense medicament from the reservoir, the dispensing mechanism comprising a sleeve configured to rotate during the dispensing of medicament and having a plurality of formations at an end of the sleeve; and a dosage measurement system comprising at least one mechanically actuated sensor configured such that, in use, rotation of the sleeve causes successive formations to engage the sensor such that the sensor detects rotation of the sleeve and a processor configured to determine a dosage dispensed from the medicament reservoir based on the detected rotation of the sleeve.

Abstract: An elevator system includes at least one car and at least one counterweight. At least two support means having different physical properties are arranged between the at least one car and the at least one counterweight.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A solenoid valve, for controlling a brake pressure of a wheel brake of a slip-regulatable hydraulic brake system for a motor vehicle, includes a valve element, valve insert, valve seat, spring device, electromagnetic actuator, and armature. The valve element is longitudinally movably positioned at least partially in the valve insert, positioned between the armature and the valve seat, and configured to interact with the valve seat. The spring device, in an assembled position, has a force component acting on the valve element in an opening direction with respect to the valve seat. The electromagnetic actuator is configured to act on the valve element in a closing direction with respect to the valve seat. The valve element has a contact surface operatively connecting the valve element and armature, and configured such that a central axis of the valve element and the contact surface form a non-rectangular intersection angle.

Abstract: A drive train has a hydrodynamic retarder including a rotating bladed rotor and bladed stator, forming a working chamber for hydrodynamic transmission of power from rotor to stator, a power input feeding drive power to the retarder, and a synchronized separating clutch connected between power input and rotor. The clutch has two clutch halves, friction elements contacting each other and mechanical blocking elements. The friction elements equalize rotational speed between clutch halves, and the blocking elements form-lockingly connect the clutch halves. The clutch has an actuator displaceable along a displacement travel, over a first distance bringing the friction elements into mutual contact, and a second distance adjoining the first distance to synchronize the friction elements and rotational speed for locking with the blocking elements. At least one displacement sensor directly or indirectly detects displacement travel by the actuator and/or position of the actuator on the displacement travel.

Abstract: The present invention provides a method for designing of a piece of apparel in particular an upper of a shoe, comprising the steps of providing at least one first panel including a plurality of feature points in an essentially two-dimensional configuration, arranging the at least one first panel on a first reference body in a three-dimensional configuration representing the piece of apparel to be designed, generating a first mapping between the two-dimensional configuration of the at least one first panel and the three-dimensional configuration of the at least one first panel using the plurality of feature points and designing the piece of apparel using the first mapping.

Abstract: The disclosure is directed to a cutting blade for a cutter head and includes a base body having a fastening arrangement for fastening the cutting blade to a cutter head as well as a blade edge. The base body and the blade edge are made of a biodegradable natural substance. Alternatively, the base body is made of a non-biodegradable plastic and the blade edge is made at least in part of a biodegradable material.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CD80 extracellular domain Fc-fusion protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.

Abstract: The metal organic framework (MOF) MIL-100(Al) can be produced in a process in which aluminum nitrate and trimesic acid are brought to react with one another in an alcohol/water mixture under the action of NH3 and/or an NH3-releasing compound under mild conditions.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: The present invention provides a method for designing of a piece of apparel in particular an upper of a shoe, comprising the steps of providing at least one first panel including a plurality of feature points in an essentially two-dimensional configuration, arranging the at least one first panel on a first reference body in a three-dimensional configuration representing the piece of apparel to be designed, generating a first mapping between the two-dimensional configuration of the at least one first panel and the three-dimensional configuration of the at least one first panel using the plurality of feature points and designing the piece of apparel using the first mapping.

Abstract: A method for controlling a separating clutch in a power train of a vehicle having a drive motor and a retarder. The clutch is arranged such that a rotor of the retarder is switched into a drive connection with the motor and/or power train via the clutch and a working chamber of the retarder can be filled with an operating medium to build up a braking power such that braking torque is exerted by the retarder onto the power train and/or motor. A control system switches the clutch into a closed or an open position. The switching of the clutch into the closed position occurs depending on an input signal to the controller, and the clutch is switched back into the open position depending on essentially no medium being present in the working chamber of the retarder and that predetermined limits of an operating and/or environmental parameter are not exceeded.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: A chair, such as a conference or office chair, includes a seat support; a backrest support; a storage member formed as a force storage element; and a transmission coupling the seat support with the backrest support which allows a pivoting of the backrest support and the seat support between an upright position and a backwardly pivoted position according to a predetermined sequence of movements. The force storage element is coupled with the seat support and the backrest support such that the predetermined sequence of movements is facilitated and the storage member provides a force restoring in the upright position and wherein the flexibly elastic storage member forms in conjunction at least with a first articulated rotation point of the transmission a kinematic chain.

Abstract: A catching device for a traveling body in an elevator system and a method for unblocking the catching device include at least two retaining units that can be brought into a blocked state and into an unblocked state, the retaining units retaining the traveling body on a rail in the blocked state. The retaining units are connected to the traveling body such that each of the retaining units and the traveling body can be slid relative to each other within a limited sliding displacement. A first sliding displacement of a first of the retaining units is longer than a second sliding displacement of a second of the retaining units.

Abstract: An illumination module for generating a patterned illumination with minimal ambiguity includes an array of light sources having different respective near-field intensity profiles. The illumination module also includes an optical assembly. The optical assembly and the array of light sources can be operable to substantially replicate the different respective near-field intensity profiles of the light sources in the far-field thereby generating a patterned illumination. The patterned illumination can exhibit reduced ambiguity in some instances.

Abstract: The present invention relates to the field of oncolytic viruses and in particular to a recombinant rhabdovirus, such as vesicular stomatitis virus encoding in its genome for a CCL21 protein. The invention is further directed to the use of the recombinant virus in the treatment of cancer, and also to methods for producing such viruses.