Abstract: A method of preventing or reducing dermatological side effects of the therapeutic agents in a subject without substantial loss in efficacy, where the therapeutic agents would otherwise have significant effects, is described. In particular, the beneficial effects are achieved by using an alpha-2 adrenergic agonist to isolate body areas from pharmacological effects of the therapeutic agents, such as a chemotherapeutic agent, and to prevent or reduce inflammatory processes.

Abstract: Colorant Compositions free of cochineal red are described. The colorant compositions mimic the color of cochineal red and they are stable in the pressure of active materials typically found in cosmetic compositions.

Abstract: A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

Abstract: An aircraft divan includes a lateral bracket connecting between front and rear legs with lateral bracket front and rear ends, a first track defined by the lateral bracket between the lateral bracket front and rear ends, an upright, having upright top and bottom ends, a second track defined by the upright between the upright top and bottom ends, a seat pan having seat pan front and rear ends, the seat pan being slidingly connected to the first track adjacent to the seat pan rear end, and a backrest having backrest top and bottom ends, the backrest being slidingly connected to the second track adjacent to the backrest top end. The seat pan rear end is pivotably connected to the backrest adjacent to the backrest bottom end such that movement of the seat pan is transmitted to the backrest so as to move together between upright and berth positions.

Abstract: The invention relates to a method of treating a viral infection caused by or associated with SARS-CoV-2 in a subject, the method comprising administering to the subject by inhalation intraorally and/or intranasally a therapeutically effective amount of a formulation comprising niclosamide, or a pharmaceutically acceptable salt thereof, and a cyclodextrin.

Abstract: A face milling tool includes a tool body having an axial front end surface with several seats. Each seat has support surfaces for rotationally locking and supporting a tangential cutting insert in the seat. One of the support surfaces is a flat axial support surface for supporting the tangential cutting insert in an axial direction defined by the central rotation axis. The flat axial support surface extends perpendicular to the central rotation axis and is situated axially foremost in the seat. A side wall of each seat is formed out of round side support surfaces. Each tangential cutting insert includes an axial back side with a flat axial contact surface abutting the flat axial support surface and a projecting member extending axially from the flat axial contact surface and having a circumferential side surface forming out of round side contact surfaces abutting the out of round side support surfaces.

Abstract: An aircraft divan includes a lateral bracket connecting between front and rear legs with lateral bracket front and rear ends, a first track defined by the lateral bracket between the lateral bracket front and rear ends, an upright, having upright top and bottom ends, a second track defined by the upright between the upright top and bottom ends, a seat pan having seat pan front and rear ends, the seat pan being slidingly connected to the first track adjacent to the seat pan rear end, and a backrest having backrest top and bottom ends, the backrest being slidingly connected to the second track adjacent to the backrest top end. The seat pan rear end is pivotably connected to the backrest adjacent to the backrest bottom end such that movement of the seat pan is transmitted to the backrest so as to move together between upright and berth positions.

Abstract: The nacelle can have an inlet fluidly connecting a main gas path of a gas turbine engine core, the inlet having an inlet edge connecting an external skin to an internal duct wall, and a step formed in a surface of at least one of the skin and the duct wall, the step delimiting a first portion of the surface from a second portion of the surface, the second portion of the surface being recessed relative to the first portion of the surface, the second portion of the surface extending away from both the step and the inlet edge, whereas the first portion of the surface extends between the inlet edge and the step.

Abstract: The nacelle can have an inlet portion having a duct wall and an outer skin, the duct wall being annular around an axis and having a surface forming a radially-outer delimitation to a gas path upstream of a fan area, the duct wall extending from a rounded inlet edge of the nacelle to the fan area, a cavity located inside the inlet portion, a compressed air inlet leading into the cavity, and an outlet fluidly connecting the cavity to the gas path, the outlet having a plurality of apertures disposed circumferentially around the duct wall, the apertures sloping circumferentially.

Abstract: A milling tool for face milling includes a tool body and a plurality of cutting members arranged successively along a periphery of the tool body. Each cutting member includes a main cutting edge provided for a roughing operation and a subset having a first, a second and a third secondary cutting edge provided for a finishing operation. The first and third secondary cutting edges extend in a direction perpendicular to an axial direction and the second secondary cutting edge extends between the first and third secondary cutting edge. The main cutting edges are situated at the same radial position and the first secondary cutting edges are situated at the same axial position. A first end point of the second secondary cutting edges successively progress radially inward and a second end point of the second secondary cutting edges successively progress radially inward and axially outward along the periphery of the tool body.

Abstract: A method of treating hand-foot syndrome (palmar-plantar erythrodysesthesia) and symptoms associated therewith in a patient undergoing or scheduled to undergo chemotherapy is claimed. The method involves topically administering a pharmaceutical composition comprising an effective amount of an alpha adrenergic receptor agonist, pharmaceutically acceptable salt thereof, or combinations thereof; and a pharmaceutically acceptable carrier to the affected areas of skin or to the hands and feet.

Abstract: An interior configuration for an aircraft, comprising a bed positioned adjacent to one side of a fuselage on a floor of a cabin within the aircraft; and a movable table positioned in relation to the bed so that the movable table may be positioned over at least a portion of the bed.

Abstract: An actuatable boring bar is configured to place a cutting insert cartridge received onto the boring bar in a cutting position when the centrifugal force generated by the rotation of the boring bar about the rotation axis reaches a centrifugal force threshold and in a non-cutting position when the centrifugal force generated by the rotation of the boring bar about the rotation axis is below the centrifugal force threshold. The boring bar is further configured so that the cutting insert cartridge can be set-up onto the boring bar in the cutting position.

Abstract: A method of preventing or reducing dermatological side effects of the therapeutic agents in a subject without substantial loss in efficacy, where the therapeutic agents would otherwise have significant effects, is described. In particular, the beneficial effects are achieved by using an alpha-2 adrenergic agonist to isolate body areas from pharmacological effects of the therapeutic agents, such as a chemotherapeutic agent, and to prevent or reduce inflammatory processes.

Abstract: The present invention relates to a process for preparing an extract from one or more botanical raw materials, such as Indigo Naturalis and the extract itself. The present invention also relates to a composition comprising the extract, as well as the use of composition in medical or cosmetic applications.

Abstract: A pharmaceutical or cosmetic composition is provided. The composition includes an Indigo Naturalis or Indigo-producing plant extract, for inhibiting Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus. A method of inhibiting Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus, is also provided. The method includes contacting a cell with an effective amount of an Indigo Naturalis or Indigo-producing plant extract.

Abstract: A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

Abstract: A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.

Abstract: An aircraft divan includes a lateral bracket connecting between front and rear legs with lateral bracket front and rear ends, a first track defined by the lateral bracket between the lateral bracket front and rear ends, an upright, having upright top and bottom ends, a second track defined by the upright between the upright top and bottom ends, a seat pan having seat pan front and rear ends, the seat pan being slidingly connected to the first track adjacent to the seat pan rear end, and a backrest having backrest top and bottom ends, the backrest being slidingly connected to the second track adjacent to the backrest top end. The seat pan rear end is pivotably connected to the backrest adjacent to the backrest bottom end such that movement of the seat pan is transmitted to the backrest so as to move together between upright and berth positions.

Abstract: A refined Indigo Naturalis extract or Indigo-producing plant extract containing at least 65% (w/w) an indirubin derivative based on total weight of active ingredients is described. Also described are a pharmaceutical composition containing the refined extract, and the use of the pharmaceutical composition for treating or alleviating a disease or condition.