Patents by Inventor Philippe Delagrange

Philippe Delagrange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for treating tubulin carboxypeptidases associated diseases
    Patent number: 11613753
    Abstract: Using chemical proteomics with a potent unique irreversible inhibitor, inventors found that major brain tubulin carboxypeptidase (TCP) is a complex of vasohibin-1 (VASH1) with the Small Vasohibin-Binding Protein (SVBP). VASH1 and its homologue vasohibin-2 (VASH2), when complexed with SVBP, exhibit robust and specific Tyr/Phe carboxypeptidase activity on microtubules. Accordingly inventors are the first to identify the enzymatic activity of vasohibin and vasohibin/SVBP complex. Knock down of vasohibins or SVBP in cultured neurons results in a marked reduction of tyrosinated ?-tubulin levels and onset of severe differentiation defects. Furthermore, knock down of vasohibins disrupts neuronal migration in developing mouse neocortex. These results establish vasohibin/SVBP complexes as TCP enzymes.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: March 28, 2023
    Assignees: LES LABORATOIRES SERVIER, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Annie Andrieux, Marie-José Moutin, Christophe Bosc, Chrystelle Aillaud, Leticia Peris, Philippe Delagrange
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING TUBULIN CARBOXYPEPTIDASES ASSOCIATED DISEASES
    Publication number: 20200407726
    Abstract: Using chemical proteomics with a potent unique irreversible inhibitor, inventors found that major brain tubulin carboxypeptidase (TCP) is a complex of vasohibin-1 (VASH1) with the Small Vasohibin-Binding Protein (SVBP). VASH1 and its homologue vasohibin-2 (VASH2), when complexed with SVBP, exhibit robust and specific Tyr/Phe carboxypeptidase activity on microtubules. Accordingly inventors are the first to identify the enzymatic activity of vasohibin and vasohibin/SVBP complex. Knock down of vasohibins or SVBP in cultured neurons results in a marked reduction of tyrosinated ?-tubulin levels and onset of severe differentiation defects. Furthermore, knock down of vasohibins disrupts neuronal migration in developing mouse neocortex. These results establish vasohibin/SVBP complexes as TCP enzymes.
    Type: Application
    Filed: October 26, 2018
    Publication date: December 31, 2020
    Inventors: Annie ANDRIEUX, Marie-José MOUTIN, Christophe BOSC, Chrystelle AILLAUD, Leticia PERIS, Philippe DELAGRANGE
  • Indole compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 8003682
    Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 represents a linear or branched (C1-C6)alkyl group, and n represents from 1 to 6. Medicaments.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: August 23, 2011
    Assignee: Les Laboratories Servier
    Inventors: Pascal Marchand, Vincent Babonneau, Sylvie Piessard, Muriel Duflos, Jean Albert Boutin, Valérie Audinot, Philippe Delagrange, Daniel-Henri Caignard
  • Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them
    Patent number: 7947852
    Abstract: Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: May 24, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Said Yous, Mohamed Ettaoussi, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • INDOLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20100204276
    Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3, together with the nitrogen atom carrying them, form a heterocycle having from 5 to 8 ring members, and n represents from 2 to 6. Medicinal products containing the same which are useful in treating disorders of the to melatoninergic system.
    Type: Application
    Filed: October 17, 2007
    Publication date: August 12, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Pascal Marchand, Vincent Babonneau, Sylvie Piessard, Muriel Duflos, Jean Albert Boutin, Valerie Audinot, Philippe Delagrange, Daniel-Henri Caignard
  • NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20100168244
    Abstract: Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Application
    Filed: July 1, 2008
    Publication date: July 1, 2010
    Applicant: LESS LABORATOIRES SERVIER
    Inventors: Said Yous, Mohamed Ettaoussi, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    Publication number: 20100137446
    Abstract: Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, R2 represents a fluorine atom or an alkyl group substituted by one or more fluorine atoms. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
    Type: Application
    Filed: July 1, 2008
    Publication date: June 3, 2010
    Inventors: Said Yous, Mohamed Ettaoussi, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Indole compounds, a process for their preparation and pharmaceutical compositions containing them.
    Publication number: 20100063128
    Abstract: Compounds of formula (I): wherein: R1 represents an alkyl, cycloalkyl or cycloalkylalkyl group, R2 represents a linear or branched (C1-C6)alkyl group, and n represents from 1 to 6.
    Type: Application
    Filed: October 17, 2007
    Publication date: March 11, 2010
    Inventors: Pascal Marchand, Vincent Babonneau, Sylvie Piessard, Muriel Duflos, Jean Albert, Valerie Audinot, Philippe Delagrange, Daniel-Henri Caignard
  • Naphthalene compounds
    Patent number: 7462741
    Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: December 9, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Naphthalene compounds
    Patent number: 7435850
    Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: October 14, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Naphthalene compounds
    Publication number: 20080004350
    Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Application
    Filed: June 29, 2007
    Publication date: January 3, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Naphthalene compounds
    Publication number: 20080004348
    Abstract: A compound selected from those of formula (I): wherein: R1 represents a group R4 or NHR4, wherein R4 is as defined in the description; R2 represents a substituted linear or branched (C1-C6)alkyl group; R3 represents a hydrogen or halogen atom or a linear or branched (C1-C6)alkyl or linear or branched (C2-C6)alkenyl group. Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 3, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Matthieu Desroses, Jean-Albert Boutin, Valerie Audinot
  • Naphthalene compounds
    Publication number: 20080004349
    Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 3, 2008
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
  • Isoquinoline compounds
    Publication number: 20070191328
    Abstract: The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group or a group X represents N or NR1, R2 represents an alkoxy, cycloalkyloxy or cycloalkylalkyloxy group. and medicinal products containing the same which are useful in treading or in preventing melatoninergic disorder.
    Type: Application
    Filed: March 20, 2007
    Publication date: August 16, 2007
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Sophie Poissonnier-Durieux, Valerie Wallez, Anne Gasnereau, Said Yous, Daniel Lesieur, Philippe Delagrange, Pierre Renard, Caroline Bennejean, Jean Boutin, Valerie Audinot
  • Polycyclic azaindole compounds
    Patent number: 7235550
    Abstract: The invention relates to compounds of formula (I): wherein: G1 represents an alkylene chain as defined in the description, A represents R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together form oxo, R4 and R5 represent hydrogen, R1 is as defined in the description, and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: June 26, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Gérald Guillaumet, Marie-Claude Viaud, Hervé Van de Poel, Philippe Delagrange, Caroline Bennejean, Pierre Renard
  • Substituted biphenyl compounds
    Publication number: 20070123529
    Abstract: The invention relates to compound of formula (I) wherein: B represents hydrogen, COOR, CONRR?, or (C1-C6)alkyl substituted by COOR, CONRR?, or OR, G1 represents —X?—(CH2)n—X—(CH2)m—X?— chain wherein X, X?, X?, n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G2 represents alkylene chain as defined in the description, and A represents NRCOR?, NRCSR?, CONRR?, CSNRR?, NRCONR?R?, or NRCSNR?R?. and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
    Type: Application
    Filed: December 18, 2006
    Publication date: May 31, 2007
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Carole Descamps-Francois, Said Yous, Daniel Lesieur, Gerald Guillaumet, Marie-Claude Viaud, Herve Da-Costa, Caroline Bennejean, Philippe Delagrange, Pierre Renard
  • Isoquinoline compounds
    Patent number: 7214689
    Abstract: The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group X represents N or NR1, R2 represents an alkoxy, cycloalkyloxy or cycloalkylalkyloxy group. and medicinal products containing the same which are useful in treading or in preventing melatoninergic disorder.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: May 8, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Sophie Poissonnier-Durieux, Valérie Wallez, Anne Gasnereau, Said Yous, Daniel Lesieur, Philippe Delagrange, Pierre Renard, Caroline Bennejean, Jean Albert Boutin, Valérie Audinot
  • Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
    Patent number: 7183318
    Abstract: The invention concerns compounds of formula (1): R-A-R? wherein: A is as defined in the description; R represent a group (V), (VI), (VII), or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R? represents a —(CH2)t—R5 group wherein t and R5 are as defined in the description, and medicaments containing the same
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: February 27, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frederique Klupsch, Gerald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
  • Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same
    Patent number: 7161035
    Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR? group, or a (C1–C6)alkyl group substituted by a COOR, CONRR? or OR group, G1 represents a —X?—(CH2)n—X—(CH2)m—X?— chain wherein X, X?, X?, n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G2 represents an alkylene chain as defined in the description, and A represents a NRCOR?, NRCSR?, CONRR?, CSNRR?, NRCONR?R? or NRCSNR?R? group.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 9, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Carole Descamps-Francois, Said Yous, Daniel Lesieur, Gérald Guillaumet, Marie-Claude Viaud, Hervé Da Costa, Caroline Bennejean, Philippe Delagrange, Pierre Renard
  • Substituted cyclic compounds
    Patent number: 7126012
    Abstract: The invention concerns compounds of formula (I): R-A-R? wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R? represents a —(CH2)t-R5 group wherein t and R5 are as defined in the description
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: October 24, 2006
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frederique Klupsch, Gerald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renaud, Philippe Delagrange