Patents by Inventor Philippe L'Hostis

Philippe L'Hostis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4310514
    Abstract: Immunologically active compounds of the formula: ##STR1## wherein R.sub.1 is C.sub.1-7 alkyl, substituted C.sub.1-7 alkyl; phenyl; or substituted phenyl;R.sub.2 is hydrogen; or C.sub.1-10 alkyl;R.sub.3 and R.sub.4 may be the same or different and are each independently acyl of the formula: ##STR2## where X is --O--, --S--, or ##STR3## R.sub.9, R.sub.10 and R.sub.12 may be the same or different and are each independently hydrogen; C.sub.1-20 alkyl; C.sub.1-20 alkylcarbonyloxy; amino; benzyl; C.sub.1-20 alkoxymethyl; or C.sub.1-20 alkylamido;r is 0 or 1; s is 0 or 1; and t is 0-20, provided that s may only be 0 when r and t are greater than 0, or when r is 0 and R.sub.11 is amino, phenyl, substituted phenyl, 1-adamantyl, or heterocycle selected from the group consisting of 2- or 3-furyl, 2- or 3-thienyl, 2- or 3-pyrrolidinyl, 2-, 3-, or 4-pyridyl, and 1-tetrazolyl, said hetero-cycle optionally substituted with C.sub.1-20 alkylcarbonyl; andR.sub.11 is hydrogen; C.sub.1-30 alkyl; C.sub.2-30 alkenyl; C.sub.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: January 12, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Philippe L. Durette
  • Patent number: 4273975
    Abstract: The circuit breaker comprises a case, a rocking lever pivotally mounted in the case, said rocking lever having at least one sharp pin at its end with the bottom of the case supporting at least two terminals, a two-arm blade substantially shaped as a hair-pin cooperating by means of the first arm thereof with the lever to move by swivelling and sliding and to bring the second arm of the blade in contact either with two terminals or, on the contrary, with only one terminal.
    Type: Grant
    Filed: April 9, 1979
    Date of Patent: June 16, 1981
    Assignee: Nordic Finance and Trade (Panama) Ltd. Inc.
    Inventor: Philippe L. Vandame
  • Patent number: 4256735
    Abstract: 2-Amino-2-deoxy-glycoses of the general structural formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl (1-7C), substituted alkyl (1-7C), phenyl, substituted phenyl, benzyl, or substituted benzyl;R.sub.2 is alkyl, substituted alkyl, phenyl, or substituted phenyl;R.sub.3 is H or lower alkyl (1-10C) with the proviso that when the aminoglycose has the 2-amino-2-deoxy-D-glucose configuration, R.sub.3 cannot be H;R.sub.4 and R.sub.5 are same or different and are H, aliphatic or aromatic acyl (2-21C) or substituted acyl (2-21C);R.sub.6 is H, or R.sub.6 -R.sub.7 together is --CH.sub.2 --CH.sub.2 --CH.sub.2 --,R.sub.7 is H, alkyl (1-7C), hydroxymethyl, mercaptomethyl, benzyl, or substituted benzyl;R.sub.8 and R.sub.9 each is carboxyl, esterified carboxyl (1-7C), amidated carboxyl, or mono- or di-alkyl-(1-3C)-amidated carboxyl;Provided that when R.sub.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: March 17, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Tsung-Ying Shen
  • Patent number: 4250318
    Abstract: There are disclosed 3-substituted phenyl-5-hydroxymethyl oxazolidinones which possess anti-depressant properties. The compounds are prepared by cyclizing, with ethyl carbonate, 1-substituted phenylamino-2,3-propanediol compounds.
    Type: Grant
    Filed: August 9, 1978
    Date of Patent: February 10, 1981
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Colette A. Douzon, Guy R. Bourgery, Claude G. Gouret, Gisele C. Mocquet, Jean-Alain Coston
  • Patent number: 4228274
    Abstract: The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an .omega.-aminoalkylthio, .omega.-aminoalkyloxy or .omega.-aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These .omega.-amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: October 14, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Mitree M. Ponpipom, Robert L. Bugianesi, Philippe L. Durette, Howard M. Katzen, Tsung-Ying Shen
  • Patent number: 4150029
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen or CONHR.sub.7 and R.sub.7 is methyl or isopropyl,And whereinWhen R.sub.1 is hydrogen: R is p-nitro, p-cyano; p-aldehydo; p-acetyl; m-ethyl; m-nitro; m-bromo; 3,4-dimethyl; m-NH.sub.2 ; p-methylamino; p-dimethylamino; p-diethylamino; p-methylbenzylamino; p-pyrrolidino; p-piperidino; SR.sub.4 in para position in which R.sub.4 is alkyl having 1 to 4 carbon atoms or cyclohexyl; OR.sub.5 is para position in which R.sub.5 is alkyl having 2 to 7 carbon atoms, cyclohexyl, cyclohexylmethyl, acetylmethyl; cyanomethyl, alkene-2 yl having 3 to 5 carbon atoms, butene-3 yl, cyclohexene-1 methyl, propargyl, butyne-2 yl, ##STR2## in which n is one or 2 and when n is one, R.sub.6 is hydrogen, o-fluoro, o-methyl, m-chloro, m-fluoro, m-methyl, m-trifluoromethyl, p-chloro, p-bromo-, p-fluoro, p-cyano, p-nitro or p-dimethylamino and when n is 2, R.sub.6 is hydrogen; and 3-methyl-4-benzyloxy:When R.sub.1 is CONHR.sub.7 and R.sub.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: April 17, 1979
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Colette A. Douzon, Guy R. Bourgery, Claude J. Gouret, Gisele C. Mocquet, Jean A. Coston
  • Patent number: 4092179
    Abstract: A high-strength, cold rolled steel sheet product characterized by a rimmed surface and an aluminum killed, columbium-containing core is produced by hot rolling at a finishing temperature above its Ar.sub.3 temperature and coiling at a temperature between 1000.degree. F. and 1200.degree. F., cold rolling between 50% and 90% reduction, batch annealing to recrystallize the coil, and temper rolling between 0.75% and 2.0% temper elongation. The product is non-aging, has a 50,000 p.s.i. minimum yield strength in the temper rolled condition, good formability, and a surface quality equivalent to that of Drawing Quality Rimmed Steel.
    Type: Grant
    Filed: December 27, 1976
    Date of Patent: May 30, 1978
    Assignee: Jones & Laughlin Steel Corporation
    Inventors: Philippe L. Charpentier, Robert H. Goodenow, William E. Dennis
  • Patent number: 4087726
    Abstract: In a constant frequency chopper for low-rate supply for an inductive load, a cut-off capacitor discharge circuit is added which shunts the cut-off capacitor and which, when the motor is required to operate at a low rate, helps to bypass the excess energy stored in the cut-off capacitor.
    Type: Grant
    Filed: July 21, 1976
    Date of Patent: May 2, 1978
    Assignee: Jeumont-Schneider
    Inventors: Alain P. Bourguet, Philippe L. Gantois
  • Patent number: 3951026
    Abstract: A punching and nibbling press with a rotatable turret comprised by an upper and a lower horizontal plate vertically spaced apart, and each formed with housings which in the upper plate receive punch members and in the lower plate receive die members corresponding with the punch members. Each set of housings is arranged in a ring shaped array about the axis of rotation of the turret. The housings are of large, medium and small relative sizes so that large, medium and small punch members can be fitted in the respective housings in the upper plate, and large, medium and small die members in the housings in the lower plate. When at least one of the large punch members is not required and additional small punch members are needed, a large punch member is removed from its housing and is replaced by an intermediate member formed with two small housings to receive two small punch members.
    Type: Grant
    Filed: September 9, 1974
    Date of Patent: April 20, 1976
    Inventor: Philippe L. Beauplat
  • Patent number: 3938416
    Abstract: A puching press with a very strong main swanneck frame having an upper arm carrying a punching head equipped with an actuating slide, and a lower arm provided with an anvil. A rotary turret is provided with a plurality of punches engageable selectively with the actuating slide by rotation of the turret, and the turret is also provided with a plurality of punching dies each corresponding to a punch and locatable over the anvil by synchronous rotation with the punches. The turret is mounted on a second swanneck frame disposed outside of the slot of the first swanneck frame.
    Type: Grant
    Filed: September 5, 1974
    Date of Patent: February 17, 1976
    Inventor: Philippe L. Beauplat