Abstract: Disclosed herein are devices for mechanically removing clot and/or other material from implants implanted in the vasculature of a patient, and associated systems and methods. In some embodiments, a system for removing clot material from an implant—such as a stent—includes a clot treatment device configured to be deployed within the stent, a handle, and a first elongate member and a second elongate member coupling the clot treatment device to the handle. The first elongate member couples a first end portion of the clot treatment device to the handle, and the second elongate member couples a second end portion of the clot treatment device to an actuator of the handle. Actuation of the actuator is configured to move the second elongate member relative to the first elongate member to move the first and second end portions toward one another to radially expand the clot treatment device.

Abstract: Single and dual frame prosthetic venous valve assemblies, and catheter delivery systems and methods, are disclosed. A representative dual frame venous valve assembly includes an outer valve frame having a lumen and a frame and venous valve assembly arranged within the lumen. The frame and venous valve assembly, which also may be a stand-alone prosthetic venous valve assembly, includes an inner valve frame having a frame matrix forming lateral valve supports and valve commissure supports; a polymeric frame coating encapsulating the frame matrix; and a one or more polymeric leaflets integrally formed with or coupled to the polymeric frame coating, with each leaflet moveable between an open or partially open state and a closed or partially closed state. A delivery catheter includes keys or slots for insertion of locking tabs of the outer valve frame, and a deployment control handle for controlling deployment of the venous valve assembly.

Abstract: A delivery device for delivering, for example, a therapeutic substance, that includes a needle having a needle lumen and a plunger that is configured to move through the needle lumen; a first translation screw attached to the needle and positioned within a first threaded passage; a second translation screw attached to the plunger and positioned within a second threaded passageway; and a device actuator. Actuation of the device actuator causes rotation of the first threaded passage and rotation of the second threaded passage, which causes the first translation screw to translate through the first threaded passage and move the needle and causes the second translation screw to translate through the second threaded passage and move the plunger through the needle lumen.

Abstract: A method for deploying an expandable prosthetic heart valve in a patient includes introducing a guidewire into a patient and advancing the guidewire through a vasculature of a patient to a deployment site. A distal end portion of a delivery apparatus and the prosthetic heart valve mounted in a radially compressed configuration on an expandable member of the distal end portion are advanced over the guidewire. The prosthetic heart valve is positioned at the deployment site. The expandable member is radially expanded, causing the prosthetic heart valve to radially expand to a radially expanded configuration. The prosthetic heart valve comprises an expandable metal frame and one or more leaflets attached to the frame, wherein the frame comprises a plurality of struts arranged to form two circumferentially extending rows of hexagonal shaped cells.

Abstract: A system for delivering an implant device to a vascular site in a patient a delivery pusher apparatus, an implant device detachably connected to the delivery pusher apparatus by a tether having a distal end connected to a proximal end of the implant device, wherein the tether is substantially non-tensioned when connecting the implant device to the delivery pusher, and an electrical heating element configured coaxially around at least a portion of the tether, wherein heat generated by the heating element severs the tether at a point near the proximal end of the implant device.

Abstract: Disclosed herein are devices for mechanically removing clot and/or other material from implants implanted in the vasculature of a patient, and associated systems and methods. In some embodiments, a system for removing clot material from an implant—such as a stent—includes a clot treatment device configured to be deployed within the stent, a handle, and a first elongate member and a second elongate member coupling the clot treatment device to the handle. The first elongate member couples a first end portion of the clot treatment device to the handle, and the second elongate member couples a second end portion of the clot treatment device to an actuator of the handle. Actuation of the actuator is configured to move the second elongate member relative to the first elongate member to move the first and second end portions toward one another to radially expand the clot treatment device.

Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes a disc defining a plane and a circumferential edge, a mandrel extending from a center of the disc that is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc, a plurality of catch mechanisms positioned circumferentially around the edge of the disc, a plurality of actuators adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc, and a plurality of filaments extending radially from the mandrel towards circumferential edge of the disc. A middle portion of each filament of the plurality of filaments contacts an end of the mandrel.

Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.

Abstract: A method for deploying an expandable prosthetic heart valve in a patient includes introducing a guidewire into a patient and advancing the guidewire through a vasculature of a patient to a deployment site. A distal end portion of a delivery apparatus and the prosthetic heart valve mounted in a radially compressed configuration along the distal end portion are advanced over the guidewire. The prosthetic heart valve is positioned at the deployment site. A screw mechanism is rotated, which exerts an axially directed onto the prosthetic heart valve, causing the prosthetic heart valve to radially expand from the radially compressed configuration to a radially expanded configuration.

Abstract: In some embodiments, a delivery device includes a device actuator and a cannula portion through which a therapeutic substance is ejected. The cannula portion includes an outer shaft, a needle that is configured to move through the outer shaft, and a plunger that is configured to move through the needle, forming a positive displacement arrangement.

Abstract: A medical device system including a first container and a second container, the first container including a first container outer body defining a first interior space connected to a first opening of the first container; and a first container-side valve configured to be activated, upon connection of the second container to the first container, from a normally closed position into the first interior space to an activated position, and the second container including a second container outer body defining a second container interior space and a stem fluidly connected to the second container interior space, wherein, upon connection of the second container to the first container, the first container-side valve is configured to be brought into contact with the stem and the stem is configured to activate the first container-side valve from the normally closed position to the activated position.

Abstract: Methods and devices for treatment of a patient's cerebral aneurysm is described. The device includes a permeable shell having a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh. The proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub. The proximal portion of the permeable shell includes a swellable polymer. The method includes advancing the implant in a microcatheter to a region of interest in the cerebral vasculature, deploying the implant within the cerebral aneurysm, and withdrawing the microcatheter from the region of interest after deploying the implant.

Abstract: Assemblies and delivery apparatus for delivering a medical device into a patient's vasculature are disclosed. In some examples, an assembly includes a delivery apparatus and a radially compressible and expandable prosthetic heart valve. The delivery apparatus includes a handle, a first shaft and a second shaft extending from the handle, and a locking mechanism to prevent axial movement of the second shaft relative to first shaft. The second shaft extends coaxially through the first shaft and includes, at a distal end portion thereof, a balloon, one or more radiopaque markers, and the prosthetic valve radially compressed over the balloon. A flared end piece extending from the first shaft covers a proximal portion of the balloon during advancing of the delivery apparatus through a patient's vasculature. The first shaft is retractable relative to the second shaft to expose the balloon from the flared end piece.

Abstract: A device and method for intravascular treatment of an embolism, and particularly a pulmonary embolism, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member having a plurality of first clot engagement members and second clot engagement members positioned about the circumference of a distal portion of the support member. In an undeployed state, individual first clot engagement members can be linear and have a first length, and individual second clot engagement members can be linear and have a second length that is less than the first length. The clot engagement members can be configured to penetrate clot material along an arcuate path and hold clot material to the clot treatment device.

Abstract: Systems and methods are disclosed for use with a valve of a heart. An implant (100) includes a wing (120); a flexible frame (124); and a pair of anchor receivers (150). A pair of shafts (660) are transluminally advanced through a catheter (40), while the shafts are each engaged with a respective anchor receiver (150), to deploy the implant out of the catheter such that the wing extends away from the anchor receivers and over a first leaflet of the valve and toward an opposing leaflet of the valve, with a contact face (122) of the wing facing the first leaflet. A pair of drivers (70) secure the implant using a pair of anchors (30) to anchor each anchor receiver to tissue at respective sites of the heart. Other implementations are also described.

Abstract: Spinal surgical procedures for implanting intervertebral devices, and associated devices and systems are described herein. A representative spinal surgical procedure can include gaining access to a diseased disc of a spine of a patient via a minimally-invasive a lateral, transpedicular, transfacet, or transforaminal access pathway. Various instruments can be inserted through the trocar to (i) remove some or all of the diseased disc, (ii) expand a disc space around the diseased disc, (iii) insert an intervertebral device into the disc space, and/or (iv) fill the intervertebral device with a fill material. Each of the aforementioned steps can be performed through the minimally-invasive access pathway provided by the trocar. This can minimize disruption to the flesh of the patient—minimizing patient pain and recovery time.

Abstract: Methods and devices for treatment of a patient's cerebral aneurysm is described. The device includes a permeable shell having a radially constrained elongated state configured for delivery within a catheter lumen, an expanded state with a longitudinally shortened configuration relative to the radially constrained state, and a plurality of elongate filaments that are woven together to form a mesh. The proximal ends of each of the plurality of filaments are gathered by a proximal hub and the distal ends of each of the plurality of filaments are gathered by a distal hub. The proximal portion of the permeable shell includes a swellable polymer. The method includes advancing the implant in a microcatheter to a region of interest in the cerebral vasculature, deploying the implant within the cerebral aneurysm, and withdrawing the microcatheter from the region of interest after deploying the implant.

Abstract: The present disclosure relates to a method, adapted to be implemented in an electronic device adapted to be powered by a power source, the method comprising monitoring a variation of an input voltage and/or an input current received from the power source while the electronic device is powered by the power source; and aborting, according to the monitored variation, a first action performed by a power consuming component of the electronic device. The present disclosure also relates to corresponding device, system, computer readable program product and computer readable storage medium.

Abstract: Methods of braiding using a braiding mechanism are described. The braiding mechanism includes a disc defining a plane and a circumferential edge, a mandrel extending from a center of the disc that is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc, a plurality of catch mechanisms positioned circumferentially around the edge of the disc, a plurality of actuators adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc, and a plurality of filaments extending radially from the mandrel towards circumferential edge of the disc. A middle portion of each filament of the plurality of filaments contacts an end of the mandrel.

Abstract: Delivery apparatus and methods for delivering a medical device into a patient's vasculature are disclosed. In some examples, a method includes inserting, into a patient, a distal end portion of a delivery apparatus including a radially compressed prosthetic valve mounted around a balloon, advancing the distal end through the patient's vasculature, and inflating the balloon to radially expand the prosthetic valve at a native heart valve. The delivery apparatus includes a handle, a first shaft and a second shaft extending from the handle, and a locking mechanism to prevent axial movement of the second shaft relative to first shaft. The second shaft extends coaxially through the first shaft and includes the balloon, the radially compressed prosthetic valve, and one or more radiopaque markers at a distal end portion. The first shaft includes an end piece covering a proximal portion of the balloon during the advancing of the delivery apparatus.