Abstract: The invention relates to a method of forming an AlMg alloy armour plate product, and comprising the steps of: (i) providing a plate product having a gauge of at least 10 mm and a chemical composition, in wt. %: Mg 2.5% to 6%, Mn 0 to 1.2%, Sc 0 to 1%, Ag 0 to 0.5%, Zn 0 to 2%, Cu 0 to 2%, Li 0 to 3%, optionally at least one or more elements selected from the group consisting of (Zr 0.03% to 0.4%, Cr 0.03% to 0.4%, and Ti 0.005% to 0.3%), Fe 0 to 0.4%, Si 0 to 0.25%, inevitable impurities and balance aluminium, and (ii) shaping said alloy plate at a temperature in a range of 200° C. to 400° C. to obtain a predetermined two- or three-dimensional formed structure.

Abstract: The present invention relates to a castable heat resistant aluminum alloy for high temperature applications such as components in combustion engines, in particular for the manufacturing of highly loaded cylinder heads, the alloy comprises the following composition: .Si: 6.5-10 wt %.Mg: 0.25-0.35 wt %.Cu: 0.3-0.7 wt %.Hf: 0.025-0.55 wt % Optionally with the addition of: .Ti: 0-0.2 wt %.Zr: 0-0.3 wt %, the balance being made of Al and unavoidable impurities including Fe.

Abstract: 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.

Abstract: The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.

Abstract: The invention relates according to a first aspect to a method for the heat treatment of a batch of castings, in which an air quench is applied to the castings of the batch that are arranged in a single layer. The invention also extends to a system for the heat treatment of a batch of castings that includes a ventilation system in order to cause a flow of cooling air, characterized in that it includes means for placing the castings of the batch in a single layer and means for bringing the single layer of castings beneath the ventilation system so as to apply an air quench to the single layer comprising the castings of the batch.

Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.

Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.

Abstract: The present invention relates to a castable heat resistant aluminium alloy for high temperature applications such as components in combustion engines, in particular for the manufacturing of highly loaded cylinder heads, he alloy comprises the following composition: .Si: 6.5-10 wt %.Mg: 0.25-0.35 wt %.Cu: 0.3-0.7 wt %.Hf: 0.025-0.55 wt % Optionally with the addition of: .Ti: 0-0.2 wt %.Zr: 0-0.3 wt %, the balance being made of Al and unavoidable impurities including Fe.

Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.

Abstract: 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

Abstract: The invention relates, according to a first aspect, to a process for the heat treatment of a cylinder head-type casting made from an aluminium alloy, in particular an alloy of aluminium, of silicon and of magnesium, and where appropriate of copper, comprising the steps of: —solution annealing (L) of the part for a time between three and ten hours; —quenching (S) of the part in air or in a fluidized bed; —tempering (H) of the part at the peak of resistance, or in the vicinity of the peak of resistance to attain a level of resistance of the part at least equal to 85% of the maximum level of resistance at the tempering temperature in question. According to a second aspect, the invention relates to the castings obtained at the end of the process according to the invention, and which have an improved fatigue resistance.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.

Abstract: The invention relates according to a first aspect to a method for the heat treatment of a batch of castings, in which an air quench is applied to the castings of the batch that are arranged in a single layer. The invention also extends to a system for the heat treatment of a batch of castings that includes a ventilation system in order to cause a flow of cooling air, characterized in that it includes means for placing the castings of the batch in a single layer and means for bringing the single layer of castings beneath the ventilation system so as to apply an air quench to the single layer comprising the castings of the batch.

Abstract: The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.

Abstract: A method of heat-treating a casting made of an aluminum-based alloy including an alloy of aluminum, silicon, and magnesium comprising heat treating the casting at a first temperature range for a first duration; gradually cooling the casting to a second temperature having a second temperature range; maintaining the casting at the second temperature range for a second duration; quenching the casting; and age hardening the casting.

Abstract: The invention concerns a method for casting a part made of metal alloy such as an aluminum alloy comprising the following steps: forming a core (N, PNC) having at least one shaft (PC) designed to form in the part a cylinder and at least one cavity (P) designed to form in the part a support and/or retaining zone for a working member, and at least a cooling unit (RE) proximate to the cavity; positioning the core in a metal mould cavity, and feeding the mould lined with its liquid alloy core by gravity. The invention is particularly useful for casting internal engine cylinder blocks with aluminum cylinders with improved geometrical and mechanical properties of the crankshaft bearing zones.

Abstract: The wheel of the invention is remarkable in that it comprises: a one-piece main portion forming a front face (FA) and a substantial portion of a rim (CJ), and including first arrangements (CI, API, HI) for a first tire seat at the opposite from the front face; and an annular add-on part (S) fitted to the main portion in continuous and airtight manner and comprising at least a portion of second arrangements (HE, APE) for a second tire seat on the side of the front face. In this way, the main portion can be made thinner and lighter in weight (AM) in the vicinity of the second arrangements. The invention is applicable to light alloy wheels for motor vehicles.