Abstract: Methods for recombinant production of vanillin and compositions containing vanillin are provided by this invention.

Abstract: A method of producing molten aluminium-lithium alloys for casting a feedstock in the form of an ingot, the method including the steps of: preparing a molten first aluminium alloy with a composition A which is free from lithium as purposive alloying element, transferring the first aluminium alloy to an induction melting furnace, adding lithium to the first aluminium alloy in the induction melting furnace to obtain a molten second aluminium alloy with a composition B having lithium as purposive alloying element, optionally adding further alloying elements to the second aluminium alloy, transferring the second alloy via a metal conveying trough from the induction melting furnace to a casting station.

Abstract: A system for adding molten lithium and inert gas in a molten aluminium or aluminium alloy melt including, a crucible defining a chamber for melting and storing molten metal, in particular molten lithium; the crucible having a sealed lid; an inert gas delivery system for maintaining chamber overpressure using inert gas; a conduit for withdrawing a portion of the molten metal from the crucible. The conduit arranged with respect to the crucible or the sealed lid so the conduit inlet can be moved below and above the molten metal surface level and arranged for feeding molten metal from the crucible to a separate holding furnace with the help of overpressure when the conduit inlet is below the molten metal surface level and arranged for feeding inert gas from the crucible to the separate holding furnace when the conduit inlet is above the molten metal surface level.

Abstract: The invention relates, according to a first aspect, to a process for the heat treatment of a cylinder head-type casting made from an aluminum alloy, in particular an alloy of aluminum, of silicon and of magnesium, and where appropriate of copper, comprising the steps of: —solution annealing (L) of the part for a time between three and ten hours; —quenching (S) of the part in air or in a fluidized bed; —tempering (H) of the part at the peak of resistance, or in the vicinity of the peak of resistance to attain a level of resistance of the part at least equal to 85% of the maximum level of resistance at the tempering temperature in question. According to a second aspect, the invention relates to the castings obtained at the end of the process according to the invention, and which have an improved fatigue resistance.

Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.

Abstract: The invention relates to a method of forming an AlMg alloy armour plate product, and comprising the steps of: (i) providing a plate product having a gauge of at least 10 mm and a chemical composition, in wt. %: Mg 2.5% to 6%, Mn 0 to 1.2%, Sc 0 to 1%, Ag 0 to 0.5%, Zn 0 to 2%, Cu 0 to 2%, Li 0 to 3%, optionally at least one or more elements selected from the group consisting of (Zr 0.03% to 0.4%, Cr 0.03% to 0.4%, and Ti 0.005% to 0.3%), Fe 0 to 0.4%, Si 0 to 0.25%, inevitable impurities and balance aluminium, and (ii) shaping said alloy plate at a temperature in a range of 200° C. to 400° C. to obtain a predetermined two- or three-dimensional formed structure.

Abstract: The present invention relates to a castable heat resistant aluminum alloy for high temperature applications such as components in combustion engines, in particular for the manufacturing of highly loaded cylinder heads, the alloy comprises the following composition: .Si: 6.5-10 wt %.Mg: 0.25-0.35 wt %.Cu: 0.3-0.7 wt %.Hf: 0.025-0.55 wt % Optionally with the addition of: .Ti: 0-0.2 wt %.Zr: 0-0.3 wt %, the balance being made of Al and unavoidable impurities including Fe.

Abstract: 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.

Abstract: The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.

Abstract: The invention relates according to a first aspect to a method for the heat treatment of a batch of castings, in which an air quench is applied to the castings of the batch that are arranged in a single layer. The invention also extends to a system for the heat treatment of a batch of castings that includes a ventilation system in order to cause a flow of cooling air, characterized in that it includes means for placing the castings of the batch in a single layer and means for bringing the single layer of castings beneath the ventilation system so as to apply an air quench to the single layer comprising the castings of the batch.

Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.

Abstract: Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections as well as their use in the treatment of a disease related to TP, such as cardiovascular diseases.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.

Abstract: The present invention relates to a castable heat resistant aluminium alloy for high temperature applications such as components in combustion engines, in particular for the manufacturing of highly loaded cylinder heads, he alloy comprises the following composition: .Si: 6.5-10 wt %.Mg: 0.25-0.35 wt %.Cu: 0.3-0.7 wt %.Hf: 0.025-0.55 wt % Optionally with the addition of: .Ti: 0-0.2 wt %.Zr: 0-0.3 wt %, the balance being made of Al and unavoidable impurities including Fe.

Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum anti-fungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.

Abstract: 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.

Abstract: The invention relates, according to a first aspect, to a process for the heat treatment of a cylinder head-type casting made from an aluminium alloy, in particular an alloy of aluminium, of silicon and of magnesium, and where appropriate of copper, comprising the steps of: —solution annealing (L) of the part for a time between three and ten hours; —quenching (S) of the part in air or in a fluidized bed; —tempering (H) of the part at the peak of resistance, or in the vicinity of the peak of resistance to attain a level of resistance of the part at least equal to 85% of the maximum level of resistance at the tempering temperature in question. According to a second aspect, the invention relates to the castings obtained at the end of the process according to the invention, and which have an improved fatigue resistance.

Abstract: The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.