Abstract: The present invention relates to a solid phase pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and an active pharmaceutical ingredient (“API”) which is a compound of formula A1 or A2 or a pharmacologically acceptable salt, solvate or hydrate thereof, wherein the API is not exposed to a basic compound.

Abstract: Systems and methods presented herein facilitate coiled tubing operations, and generally relate to automatically improving performance of coiled tubing operations in substantially real time by inferring reservoir pressure based on initial coiled tubing run conditions. For example, a method includes performing a coiled tubing operation via a coiled tubing system at least partially disposed within a wellbore. The method also includes detecting data relating to operating parameters of the coiled tubing operation via sensors of the coiled tubing system during the coiled tubing operation. The method further includes determining an initial wellbore fluid distribution in the wellbore based on the detected data prior to pumping fluid into the wellbore from a surface location relative to the wellbore. In addition, the method includes inferring a reservoir pressure of a hydrocarbon-bearing reservoir through which the wellbore extends based on the initial wellbore fluid distribution in the wellbore.

Abstract: A method for supplying and a method for obtaining, by a terminal, from a first user, a biometric signature of a second user. The terminal receives a radio signal transmitted by a transmitter device according to a near-field communication technology, via a channel using the electromagnetic wave conduction capabilities of the body of the second user when the second user comes into contact with or grazes a surface of the transmitter device and via a channel using the electromagnetic wave capabilities of the body of the first user when the first user comes into contact with or grazes the second user, and obtains, from this radio signal, the biometric signature of the second user. The biometric signature is stored in a secure memory space of the terminal in order to be used subsequently during an authentication of the first user.

Abstract: The present invention concerns a dosage form, preferably for immediate release, comprising siponimod, a moisture-protective-agent and further pharmaceutical excipients and methods for producing said dosage form.

Abstract: Systems and methods are provided for decoding secure tags using an authentication server and secure tag reader. The system can include at least one processor and at least one non-transitory memory. The memory can contain instructions that, when executed by the at least one processor, cause the secure tag reader to perform operations. The operations can include detecting a potential secure tag in an image and generating a normalized secure tag image using the image and a stylesheet. The operations can further include providing an identification request to an authentication server, the identification request including the normalized secure tag image. The operations can additionally include receiving rules for decoding tag data encoded into the secure tag as tag feature options and decoding the tag data using the received rules.

Abstract: The present invention relates to siponimod (BAB312) for use in the treatment of an autoimmune disease, wherein an immediate release dosage form is administered once daily to a patient as maintenance regimen and wherein the patient has experienced a specific titration regimen with siponimod beforehand.

Abstract: In a method for calculating, by an estimator, an instantaneous velocity vector {right arrow over (Vu)} of a rail vehicle, the estimator receives measurements from an inertial unit at a fixed point in the vehicle body and determines a mathematical model M of the dynamics of the vehicle moving on a track, the model being dependent on the bias of the inertial unit and installation parameters, a virtual sensor is determined based on the model M, the virtual sensor enabling calculation, from model parameters, two theoretical transverse velocities ?vyc, and ?vzc along axes yc and zc, respectively. An iterative estimator calculates {right arrow over (Vu)}, and includes the virtual sensor, the estimator being configured so the two theoretical transverse velocities are zero regardless of the rail configurations, the estimator enabling correction of the biases of the inertial unit and estimate installation parameters. Auxiliary velocity or distance travelled sensors are not used to calculate {right arrow over (Vu)}.

Abstract: A method for controlling the authentication of a user by an authentication device, the authentication being implemented by verification, by the authentication device, that a code entered by the user on an interaction interface of the authentication device corresponds to a predetermined code associated with the user is disclosed. A signal representative of a radio signal characteristic of an interaction of the user on the interaction interface of the authentication device is received by the user's terminal. The radio signal is transmitted by an antenna of the authentication device via a channel using electromagnetic wave conduction capacities of the user's body when the user enters the code. It is verified that the radio signal corresponds to a previously stored reference signal, and, in the event of a positive verification, a piece of data representative of the user's identity is transmitted to the authentication device for verification with the user's identity.

Abstract: This relates to a device and method for estimating the location of a guided vehicle along a guide, the device including: an attitude sensor of the guided vehicle providing values of attitude component measurements of the vehicle; a memory for storing virtual attitude beacon data including values of one or more of the attitude components of the virtual attitude beacon and at least one virtual attitude beacon attribute value, including at least one position attribute value of the beacon; and a processor configured to perform an activity of a virtual attitude beacon reader, le virtual attitude beacon reader comparing the stored virtual attitude beacon data and the vehicle attitude measurement values in order to detect an instance of a measurement value of the corresponding attitude component exceeding a value of an attitude component of the virtual attitude beacon data, the attitude component advantageously being the geographic heading.

Abstract: Systems and methods presented herein facilitate coiled tubing operations, and generally relate to the use of flow modeling to generate flow-related data that cannot be measured in order to take re-al-time decisions and real-time predictions on the outcome of future potential actions to be taken by engineers or artificial intelligence to optimize operation performance together with a general method for parameter inference for any uncertain parameters deemed important when designing cleanout operations. In certain situations, a pre-conditioning method for the determination of a reservoir pressure parameter may be used to reduce the effect of its uncertainty on design fidelity. In addition, in certain situations, a pre-conditioning method for the determination of a reservoir inflow performance parameter may be used to reduce the effect of its uncertainty on design fidelity.

Abstract: Systems and methods presented herein facilitate coiled tubing operations, and generally relate to the use of mechanical models for the automation of such coiled tubing operations in the oil and gas industry. In particular, a framework is presented that includes three main building blocks: (1) a probabilistic tubing force and depth estimation package; (2) an anomaly detection package; and (3) a mechanical failure check package, each of which are software packages executable by a surface processing system.

Abstract: Systems and methods presented herein facilitate coiled tubing operations, and generally relate to coiled tubing simulators that capture decades of expertise. In particular, the various simulators are formulated as a simulator graph search problem that enables optimal querying of the simulators (e.g., maximizing confidence and efficiency). The representation for a simulator graph is built and integrated with AI planning, constraint satisfaction programming (CSP), reinforcement learning (RL), and execution, which includes three main steps: (1) creation of a simulator graph that encodes the relations between inputs and outputs of different simulators. (2) integration of the simulator graph with an AI planner, CSP and RL, and (3) plan execution and monitoring of the plan with dynamic re-planning, as needed.

Abstract: The present invention relates to a solid phase pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and an active pharmaceutical ingredient (“API”) which is a compound of formula A1 or A2 or a pharmacologically acceptable salt, solvate or hydrate thereof, wherein the API is not exposed to a basic compound.

Abstract: Systems and methods are provided for decoding secure tags using an authentication server and secure tag reader. The system can include at least one processor and at least one non-transitory memory. The memory can contain instructions that, when executed by the at least one processor, cause the secure tag reader to perform operations. The operations can include detecting a potential secure tag in an image and generating a normalized secure tag image using the image and a stylesheet. The operations can further include providing an identification request to an authentication server, the identification request including the normalized secure tag image. The operations can additionally include receiving rules for decoding tag data encoded into the secure tag as tag feature options and decoding the tag data using the received rules.

Abstract: Disclosed is an austenitic stainless steel alloy that includes or consists of, by weight, about 24.0% to about 26.0% chromium, about 11.0% to about 13.0% nickel, about 1.0% to about 2.5% manganese, about 1.2% to about 1.6% niobium, about 1.0% to about 1.7% silicon, about 0.4% to about 0.5% carbon, about 0.2% to about 0.3% nitrogen, a balance of iron, and other inevitable/unavoidable impurities that are present in trace amounts. The elements zirconium and sulfur are excluded from the alloy beyond impurity levels. Turbocharger turbine housings made of the stainless steel alloy, and methods of making the same, are also disclosed. The stainless steel alloy is suitable for use in turbocharger turbine applications for temperatures up to and beyond about 1,050° C., such as up to about 1070° C.

Abstract: The present disclosure provides a coating composition useful as a coating on food cans, and particularly as interior white or gold food can coatings. The coating composition includes a polyester polymer preferably having a number average molecular weight (Mn) of less than 10,000, a glass transition temperature (Tg) of more than 60° C., and a hydroxyl value greater than 10 mg KOH/g resin. The polyester preferably includes one or more cyclic groups selected from a mono-cyclic group having five ring members or less, a polycyclic group, or both, preferably in a backbone of the polyester polymer.

Abstract: Doped-AlN piezoelectric materials are advantageous because they are far more compatible with complementary metal oxide semiconductor (CMOS) materials and they maintain both piezoelectric and thermodynamic stability up to very high temperatures, compared to PZT. Ab-initio calculations and targeted experimentation have identified alternative, earth-abundant, dopants for AlN from the periodic table d-block. In particular, group IVB elements, titanium (Ti), zirconium (Zr), and hafnium (Hf) induce large piezoelectric enhancements comparable to rare-earth dopants, such as Sc. This improvement is due to shifts in the sublattice atomic structure and changes in the local charge states. This invention provides a highly accessible and affordable path for technological adaptation of AlN-based piezoelectrics for sustainable, next-generation electronics.

Abstract: Device of the chip or electronic system-in-package type, comprising at least one element for protecting at least part of at least one face of the device, said protective element comprising at least: an attack detection element of the device comprising at least one GMI-effect electrically conductive material, and a magnetic field emitter to which said GMI-effect electrically conductive material is to be subjected, and wherein the GMI effect is to be achieved in said GMI-effect electrically conductive material when an exciting alternating electric current flows therethrough and when subjected to the magnetic field of the magnetic field emitter.

Abstract: An integration system and method for the manufacture of radio frequency transmission front-end modules with radio frequency integrated circuit(s) and self-biased magnetic component(s) integrated on a “Wafer Level Packaging”-type technology. This integration makes it possible to design efficient, compact and low-cost front-end modules.

Abstract: A method and device for processing a near-field communication. The device includes: at least one near-field communication antenna intended to receive a near-field electromagnetic signal and having at least one end; a switching member connected to the end of the antenna; and a controller able to receive the antenna signals and control the switching member. The switching member is able to disconnect the end of the antenna when it receives a first switching command, called an IBC command.