Abstract: The present invention concerns a dosage form, preferably for immediate release, comprising siponimod, a moisture-protective-agent and further pharmaceutical excipients and methods for producing said dosage form.

Abstract: The present invention relates to siponimod (BAF312) for use in the treatment of an autoimmune disease, wherein an immediate release dosage form is administered once daily to a patient as maintenance regimen and wherein the patient has experienced a specific titration regimen with siponimod beforehand.

Abstract: The present invention provides coating systems that use polycyclic polyester resins in combination with phenolic resins. The combination of these resin materials provides a coating composition that provides cured coatings with excellent adhesion, blush resistance, stain resistance, and corrosion resistance in a single coating composition. This makes the coating compositions well suited for use to form coatings on closures used in the packaging industry for food and beverages. In many embodiments, even though PVC and BPA materials are excluded, the coating compositions provide monocoats whose performance substantially matches and even exceeds the performance of monocoats formed from PVC and BPA containing materials.

Abstract: The present invention is based upon a coating system that uses polycyclic polyester polymers and phenolic resins. The coating system comprises first and second coatings. The first coating preferably is derived from ingredients comprising a polycyclic polyester resin having first and second fused rings that share at least two atoms in common. The second coating preferably is derived from ingredients comprising a polycyclic polyester resin that may be different than the polyester of the first coating.

Abstract: A system provides secure messaging of healthcare data and prompts message responses using prioritized hierarchical reminders. Messages can be sent and received through an application executing on a mobile device or on a web browser or application executing on any computer. The system can provide message notifications and multiple reminders to ensure that a user is reliably receiving and also reading messages. If an in-application message is not read within a time period, the message can followed by a reminder message informing the recipient that there is a secure message waiting. The reminder message can be sent using an application notification or through other channels, such as by SMS text message, automated voice telephone call, or e-mail, without including sensitive patient healthcare information.

Abstract: A coating system is provided that includes an undercoat composition that includes a thermoplastic dispersion. In certain preferred embodiments, the coating system is a multi-coat system that includes the undercoat composition and an overcoat composition that includes a thermoplastic dispersion. In one embodiment, the coating system is suitable for use on a food-contact surface of a food or beverage container.

Abstract: A modular automated collection point (ACP) comprises an array of electronically controlled lockers for receiving items for sale or for delivery to customers, a controller and user interface, a parcel weighing and dimensional measuring unit, and a package deposit unit with a one-way door for depositing items for subsequent delivery to other customers or ACPs. Each door preferably moves rapidly from the fully-open position to a partially-open position, and then slowly from the partially-open position towards a fully-closed position. Each locker may comprise a retractable handle and an elongate, rotating closure element which moves the locker door between the fully-closed (locked) position and a nearly-closed (unlocked) position. Preferably the closure element has a cylindrical outer wall which conforms slidingly to the fascia of the lockerbank so as to present a seamless appearance and prevent prising.

Abstract: Methods of performing a stimulation operation at a wellsite are disclosed. The wellsite is positioned about a subterranean formation having a wellbore therethrough and zones thereabout. The method involves establishing at least one objective for stimulating production of reservoir fluid from the subterranean formation and into the wellbore. The stimulating involves placing a stimulating fluid along the zones of the wellbore. The objective is based on wellsite data. The method also involves identifying at least one constraint for the stimulating, determining target distributions of the stimulation fluid based on the objective(s) and the constraint(s), and selecting operational parameters for the stimulating based on the constraint(s) and the target distributions. The method may also involve stimulating the subterranean formation using the target distributions and the operational parameters, monitoring the wellsite during the stimulating, and adjusting the stimulating based on the monitoring.

Abstract: An effluent treatment process and plant. The treatment includes at least one passage of the effluents through a device for biological pretreatment of the effluents, such as a bacterial bed, a lagoon or lagooning or a biological disc, at least one nitrification-denitrification of the pretreated effluents resulting from the biological pretreatment device, using a vertical-flow filter planted with rhizome plants, for example reeds, of which a lower zone is flooded and an upper zone is unflooded, and a device for injecting coagulants capable of precipitating the phosphates of effluents, for example ferric chloride salts.

Abstract: A demodulator of an FM signal modulated about a carrier frequency with a modulation frequency has an RF oscillator configured to be synchronized, under identical conditions of operation, with oscillations at first and second frequencies used in the FM signal to encode respective pieces of information. The oscillator has a magnetoresistive device; and a low-pass filter connected to an output electrode of the magnetoresistive device to filter an oscillating signal, generated by the oscillator and to a rendering terminal to provide, as a demodulated electrical signal, the filtered signal, the cut-off frequency fc at ?3 dB of this filter being strictly lower than the frequency and higher than the modulation frequency.

Abstract: This tool substantially extends in a general plane (XY) and comprises: —at least one working head (12, 13) intended to cooperate with the fastener; —a handle (14) which is integral with the or each working head; the handle extending along a longitudinal axis (X-X) and comprising a linear portion (15) and at least one connection portion (16, 17) which connects the or each working head to the linear portion, the linear portion of the handle having a section transverse to the longitudinal axis (X-X) which comprises a relatively large transverse dimension substantially parallel with the general plane of the tool (XY) perpendicular to the longitudinal axis (X-X), and a relatively small dimension perpendicular to the general plane of the tool (XY). The large dimension and the small dimension of the transverse section are changing along the longitudinal axis. Use in flat wrenches, combination wrenches and ring wrenches.

Abstract: This variable-response magnetic radiofrequency device integrated into a substrate comprises: a beam that is mobile relative to the substrate having, at each end, a transversal part mechanically anchored to the substrate and at least one central arm connecting the transversal parts to each other, at least one of the transversal parts being made out of a piezoelectric material, actuating electrodes associated with the piezoelectric material to apply a stress on the central arm, a magnetic element directly deposited on the central arm whose permeability varies as a function of the stress, and a conductive strip comprising a central part fixed to an upper face of the magnetic element opposite the lower face of this magnetic element pointed towards the central arm.

Abstract: A synthesizer includes a second frequency-synthesizing stage comprising a radiofrequency oscillator configured to oscillate at a frequency ?fo when it is synchronized with a signal s0(t), where ? is a rational number different from one such that ?f0=ft. The radiofrequency oscillator has a magnetoresistive device within which there flows a spin-polarized electrical current to generate a signal st(t) oscillating at the frequency ft on an output electrode connected to the rendering terminal. This device is formed by a stack of magnetic and non-magnetic layers, a synchronization terminal for synchronizing the frequency of the oscillating signal st(t) with the frequency of the signal received at the synchronization terminal. The synchronization terminal being connected to the output terminal of the first stage to receive the signal s0(t).

Abstract: The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: An oscillation detector having an RF oscillator configured to be synchronized with a first frequency and a comparator for distinguishing the synchronized state from the non-synchronized state of the radiofrequency oscillator on the basis of an oscillating signal produced by the radiofrequency oscillator and indicating the presence of oscillations in a frequency band around the first frequency in response to identifying the synchronized state and, in alternation, indicating the absence of oscillations in this frequency band otherwise.

Abstract: The present invention relates to a solid phase pharmaceutical composition comprising one or more pharmaceutically acceptable excipients and an active pharmaceutical ingredient (“API”) which is a compound of formula A1 or A2 or a pharmacologically acceptable salt, solvate or hydrate thereof, wherein the API is not exposed to a basic compound.

Abstract: The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract: A coating system is provided that includes an undercoat composition that includes a thermoplastic dispersion. In certain preferred embodiments, the coating system is a multi-coat system that includes the undercoat composition and an overcoat composition that includes a thermoplastic dispersion. In one embodiment, the coating system is suitable for use on a food-contact surface of a food or beverage container.

Abstract: An oscillation detector having an RF oscillator configured to be synchronized with a first frequency and a comparator for distinguishing the synchronized state from the non-synchronized state of the radiofrequency oscillator on the basis of an oscillating signal produced by the radiofrequency oscillator and indicating the presence of oscillations in a frequency band around the first frequency in response to identifying the synchronized state and, in alternation, indicating the absence of oscillations in this frequency band otherwise.

Abstract: A demodulator of an FM signal modulated about a carrier frequency with a modulation frequency has an RF oscillator configured to be synchronized, under identical conditions of operation, with oscillations at first and second frequencies used in the FM signal to encode respective pieces of information. The oscillator has a magnetoresistive device; and a low-pass filter connected to an output electrode of the magnetoresistive device to filter an oscillating signal, generated by the oscillator and to a rendering terminal to provide, as a demodulated electrical signal, the filtered signal, the cut-off frequency fc at ?3 dB of this filter being strictly lower than the frequency and higher than the modulation frequency.