Abstract: The present invention belongs to the field of the manufacture of recombinant proteins, particularly antibodies. More specifically, it relates to cell culture processes for expressing proteins with improved yield during commercial scale manufacturing.

Abstract: A locking device for locking an object capable of sliding along a cable, the device includes the cable and a clamp, the cable passing through the clamp while extending along an axis, the clamp comprising: a fixed part connected to the object, a ring comprising an elastic material with fluid behavior, the ring comprising a central cavity through which the cable passes, an actuator configured to compress the ring between two shapes, in a first shape, referred to as the open shape, the cable being able to run freely in the central cavity and in a second shape, referred to as the closed shape, the cable being compressed by the ring.

Abstract: A device for locking an object suspended from a cable passing through a clamp and extending along a substantially vertical axis, the clamp includes a fixed part, at least two moving jaws, a first actuator and a second actuator, the two jaws coming into contact with the cable to immobilize the cable by clamping in a closed position and moving away from the cable in an open position, the fixed part having as many inclined surfaces as there are jaws, each of the jaws being configured to slide along one of the inclined surfaces so as to pass from the open position to the closed position, the first actuator being configured to move the jaws upward, make them slide along their respective inclined surface and allow the clamp to close, the second actuator being configured to pull downward on the cable with respect to the fixed part and allow the clamp to open.

Abstract: A method for configuring a fixture for use in machining of sequential parts via a machine tool, for a planned machining movement of the machining element, uses a model of the part and fixture. Respective reaction forces at the plurality of part contact references are computed. Responsive to computation of a negative reaction force at a said part contact reference, a modification is made to a machining parameter.

Abstract: The present invention belongs to the field of the manufacture of recombinant proteins, particularly proteins, such as antibodies.

Abstract: A low-drag dipping sonar includes an antenna equipped with acoustic transmitters and receivers. The dipping sonar further comprises a motorized winch comprising a reel, and an actuator configured to rotate the reel and a cable wound on the reel, in that the winch is placed in the antenna, and in that the cable allows the antenna to be hooked to a carrier at its one free end of the cable.

Abstract: A gas injection system includes a tubular wall 3 capable of being thermally stressed and having a proximal extremity and a distal extremity 11, at the distal extremity, at least one extremity opening through which at least one gas is projected. A cooling is system located in the tubular wall including axial channels 12 which extend axially towards the distal extremity and in which a cooling fluid is circulated. Connecting channels 13 circumferentially join the axial channels to each other at the distal extremity of the tubular wall. The connecting channels, which circumferentially join the axial channels at the distal extremity of the tubular wall, have a rounded shape in the direction of the distal extremity.

Abstract: A low-drag dipping sonar includes an antenna equipped with acoustic transmitters and receivers. The dipping sonar further comprises a motorized winch comprising a reel, and an actuator configured to rotate the reel and a cable wound on the reel, in that the winch is placed in the antenna, and in that the cable allows the antenna to be hooked to a carrier at its one free end of the cable.

Abstract: A locking device for locking an object capable of sliding along a cable, the device includes the cable and a clamp, the cable passing through the clamp while extending along an axis, the clamp comprising: a fixed part connected to the object, a ring comprising an elastic material with fluid behavior, the ring comprising a central cavity through which the cable passes, an actuator configured to compress the ring between two shapes, in a first shape, referred to as the open shape, the cable being able to run freely in the central cavity and in a second shape, referred to as the closed shape, the cable being compressed by the ring.

Abstract: A device for locking an object suspended from a cable passing through a clamp and extending along a substantially vertical axis, the clamp includes a fixed part, at least two moving jaws, a first actuator and a second actuator, the two jaws coming into contact with the cable to immobilize the cable by clamping in a closed position and moving away from the cable in an open position, the fixed part having as many inclined surfaces as there are jaws, each of the jaws being configured to slide along one of the inclined surfaces so as to pass from the open position to the closed position, the first actuator being configured to move the jaws upward, make them slide along their respective inclined surface and allow the clamp to close, the second actuator being configured to pull downward on the cable with respect to the fixed part and allow the clamp to open.

Abstract: A gas injection system includes a tubular wall 3 capable of being thermally stressed and having a proximal extremity and a distal extremity 11, at the distal extremity, at least one extremity opening through which at least one gas is projected. A cooling is system located in the tubular wall including axial channels 12 which extend axially towards the distal extremity and in which a cooling fluid is circulated. Connecting channels 13 circumferentially join the axial channels to each other at the distal extremity of the tubular wall. The connecting channels, which circumferentially join the axial channels at the distal extremity of the tubular wall, have a rounded shape in the direction of the distal extremity.

Abstract: A forging assembly may comprise a first die and a second die configured to translate toward the second die. A first sensor may be coupled to at least one of the first die or the second die. The first sensor may be configured to output a first signal correlating to a first distance between the first die and the second die. Additional sensors may be applied to track die alignment during the forging process.

Abstract: A method for switching from a first communication interface to a second communication interface on a terminal in the process of communication. This method includes the following steps: detecting a number of commands to implement a process of replacing missing samples while audio of the communication is being decoded; and switching to a second communication interface when the number of commands exceeds a threshold. Also disclosed are a device and communication terminal implementing the method as described.

Abstract: A blowing lance tip includes a central stirring gas-supply tube, an inner coolant-inlet tube ending, at one end thereof facing the bath, in a second front wall and having a central opening, an outer coolant-outlet tube, a heat exchange space, and a stirring gas-outlet pipe leading from each opening in the front wall, wherein the second front wall has, at the central opening, an edge which is curved in axial cross-section such that a height (H3) is defined between a leading face of said edge and the third front wall, and such that, in the heat exchange space, a predetermined minimum height (H1) is present on the side facing the central opening.

Abstract: A forging assembly may comprise a first die and a second die configured to translate toward the second die. A first sensor may be coupled to at least one of the first die or the second die. The first sensor may be configured to output a first signal correlating to a first distance between the first die and the second die. Additional sensors may be applied to track die alignment during the forging process.

Abstract: Methods of refining the grain size of titanium and titanium alloys include multiple upset and draw forging. Titanium and titanium alloy workpieces are heated to a workpiece forging temperature within a workpiece forging temperature range in the alpha+beta phase field. The workpiece may comprise a starting cross-sectional dimension. The workpiece is upset forged in the workpiece forging temperature range. After upsetting, the workpiece is multiple pass draw forged in the workpiece forging temperature range. Multiple pass draw forging may comprise incrementally rotating the workpiece in a rotational direction followed by draw forging the workpiece after each incremental rotation. Incrementally rotating and draw forging the workpiece is repeated until the workpiece comprises substantially the same starting cross-sectional dimension.

Abstract: A method for switching from a first communication interface to a second communication interface on a terminal in the process of communication. This method includes the following steps: detecting a number of commands to implement a process of replacing missing samples while audio of the communication is being decoded; and switching to a second communication interface when the number of commands exceeds a threshold. Also disclosed are a device and communication terminal implementing the method as described.

Abstract: A method of processing a non-magnetic alloy workpiece comprises heating the workpiece to a warm working temperature, open die press forging the workpiece to impart a desired strain in a central region of the workpiece, and radial forging the workpiece to impart a desired strain in a surface region of the workpiece. In a non-limiting embodiment, after the steps of open die press forging and radial forging, the strain imparted in the surface region is substantially equivalent to the strain imparted in the central region. In another non-limiting embodiment, the strain imparted in the central and surface regions are in a range from 0.3 inch/inch to 1 inch/inch, and there exists no more than a 0.5 inch/inch difference in strain of the central region compared with the strain of the surface region of the workpiece. An alloy forging processed according to methods described herein also is disclosed.

Abstract: A blowing lance tip includes a central stirring gas-supply tube, an inner coolant-inlet tube ending, at one end thereof facing the bath, in a second front wall and having a central opening, an outer coolant-outlet tube, a heat exchange space, and a stirring gas-outlet pipe leading from each opening in the front wall, wherein the second front wall has, at the central opening, an edge which is curved in axial cross-section such that a height (H3) is defined between a leading face of said edge and the third front wall, and such that, in the heat exchange space, a predetermined minimum height (H1) is present on the side facing the central opening.

Abstract: Forge lubrication processes are disclosed. A solid lubricant sheet is placed between a workpiece and a die in a forging apparatus. Force is applied to the workpiece with the die to plastically deform the workpiece. The solid lubricant sheet decreases the shear factor for the forging system and reduces the incidence of die-locking.