Abstract: The present disclosure describes, in part, compositions and methods for the treatment of NASH and NASH-associated diseases. Compositions comprising an agent able to increases the expression, activity, or level of one more of a protective miRNA, preferably miR-375 are provided that may be used for the treatment of liver and/or liver-associated disease is treated in the subject.

Abstract: A recreational pack configured to hold a pair of skis or similar elongate recreational device on the back of a user. The pack includes a pouch configured to secure a portion of a pair of skis within the pouch. In this regard, the pouch includes an upper edge comprising a cinching mechanism that is configured to be opened and closed to permit access to an interior volume of the pouch, and a slit operatively disposed through a lower edge of the pouch and configured to receive a pair of skis or similar equipment within and through the slit. The pack secures the skis in a useful and efficient manner and advantageously may be folded and placed in a user’s pocket when not in use.

Abstract: Provided are systems and methods for detecting a vehicle with sensors that are not calibrated properly and calibrating such sensor in real-time. In one example, a method may include iteratively capturing sensor data of a road while the vehicle is travelling on the road; monitoring a calibration of the sensors of the vehicle based on the sensor data, determining that the sensors of the vehicle are not calibrated properly based on the monitoring, generating a calibration target of an object on the road based on the sensor data, and adjusting a calibration parameter of the one or more sensors of the vehicle based on the generated calibration target.

Abstract: A system and method including receiving a digital representation of a road that includes one or more lane representations; defining a factor graph including variable nodes and constraint nodes that encode lane boundary constraints for the lane map; translating the factor graph into a nonlinear optimization problem for altitudes of the lane map; generating a solution to the optimization problem; and generating a corrected lane map with an optimized altitude for the road based on the generated solution.

Abstract: Provided are systems and methods for detecting a vehicle with sensors that are not calibrated properly and calibrating such sensor in real-time. In one example, a method may include iteratively capturing sensor data of a road while the vehicle is travelling on the road; monitoring a calibration of the sensors of the vehicle based on the sensor data, determining that the sensors of the vehicle are not calibrated properly based on the monitoring, generating a calibration target of an object on the road based on the sensor data, and adjusting a calibration parameter of the one or more sensors of the vehicle based on the generated calibration target.

Abstract: A rigid stopper (10) made of synthetic materials, particularly for wine bottles, comprises a substantially cylindrical body (12) defining a longitudinal axis (20), with a side surface (14) and two opposing substantially flat end faces (16, 18), and at least two compressible-elastomeric “O”-rings (22, 24) seated in corresponding semicircular-circumferential-grooves (26, 28) on the side surface (14). The semicircular-circumferential-grooves (26, 28) are positioned symmetrically about a central-plane (56) toward faces (16, 18) of body (12) respectively. Faces (16, 18) are comprised of foramen (42, 44) respectively which communicate with a volute cavity (14) for the purpose of accepting a typical cork-screw-extractor.

Abstract: A combination snake catching and killing device is provided. The device includes an elongated hollow body configured to house a blade assembly with a blade used for dismembering a snake when fired. A handle assembly includes a handle, a charge handle configured to cock and fire the blade, and a grip lever configured to activate a gripping member with jaws that can grip a snake allowing a user to handle and/or relocate a snake or kill the snake, as necessary.

Abstract: A method of simulating an emergency response training scenario to users in different locations, including customizing a scenario, initiating a game state having a threat level and a time remaining, assigning a role to each of a plurality of users wherein each of the users uses a device, assigning digital assets within the scenario to each of the users, displaying an introduction sequence, initiating an incident and simultaneously notifying a first group of at least two users, logging and scoring a chosen response from the possible responses compared to a scoring system, updating the game state whereby the threat level is raised or lowered and the time remaining is increased or decreased, triggering another event to at least two of the plurality of users, and communicating a score calculated in the logging and scoring step to at least one user on one of the at least one client device.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.

Abstract: The present disclosure relates to the biosynthesis of UDP-Rhamnose and recombinant polypeptides having enzymatic activity useful in the relevant biosynthetic pathways for producing UDP-Rhamnose. The present invention also provides a method for preparing a steviol glycoside composition comprising at least one rhamnose-containing steviol glycoside.

Abstract: Client systems of a distributed database system manage execution of transactions on data stored within the distributed database system. The client systems communicate directly with database nodes of the distributed database system in order to manage transactions. The client systems interact with the database nodes of the distributed database system via a client-side interface that performs various operations to execute transactions at the distributed database nodes, including retrieving records, staging mutations or insertions, committing mutations or insertions, or rolling back mutations or insertions on records stored on the distributed database nodes. Interactions between the client-side interface and the database nodes of the distributed database system are further configured to prevent conflicts between different transactions executed by the same or different client systems at the database nodes.

Abstract: Client systems of a distributed database system execute transactions on data stored within the distributed database system. The client systems communicate directly with database nodes of the distributed database system in order to execute transactions. The client systems interact with the database nodes of the distributed database system via a client-side interface that performs various operations to execute transactions at the distributed database nodes, including retrieving records, staging mutations or insertions, committing mutations or insertions, or rolling back mutations or insertions on records stored on the distributed database nodes. Interactions between the client-side interface and the database nodes of the distributed database system are further configured to prevent conflicts between different transactions executed by one or more client systems at the database nodes.

Abstract: A watercraft mounting system that embodies a moving mounting platform and a protective hull cavity which provides protection, prevents damage and improves storage of data collection systems.

Abstract: A process for improving the grade and optical quality of zircon, comprising: baking a mixture of a zircon feed and concentrated sulphuric acid at a baking temperature in the range of from 200 up to 400° C., and for a time to form water leachable sulphates with impurities therein including at least iron and titanium; leaching the baked mixture to dissolve the leachable sulphates; and separating the zircon from the leachate containing the leached sulphates, which separated zircon is thereby of improved grade and optical quality.

Abstract: An open chamber (88) of predetermined size and shape is positioned within a pool floor (86) so as to contain a plurality of a telescopic module (10) which occupy said chamber area. Each of the telescopic module (10) is independently extended and retracted in length by the rotational direction of an electric motor (54) screw (58) concentrically contained within the confines of said telescopic module (10), establishing in selected telescopic modules a specific reef size, shape, and orientation. When a kinetic-energy (110) within the water passes over the predetermined shape, size, and orientation of the reef, a wave (140) is generated having specific features resulting from the properties of the specific reef configuration.

Abstract: A linear friction welding machine having a two-piece collet for holding a workpiece. The two-piece collet includes first and second halves that can be separated for loading the workpiece in a transverse direction, and brought together about the workpiece and locked in place to both secure the workpiece against axial movement as well as support the workpiece against transverse loads.

Abstract: In one aspect, provided herein is a polypeptide comprising a modified angiopoietin receptor or fragment thereof, wherein the polypeptide binds preferentially to angiopoietin-2 compared to angiopoeitin-1. Nucleic acid sequences encoding the polypeptide, as well as pharmaceutical uses of the polypeptide in treating diseases such as cancer and inflammation are also provided.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.

Abstract: In embodiments of the present invention improved capabilities are described for modifying a workflow condition including displaying a workflow component through a graphical user interface, where the workflow component includes at least one visual depiction of a function associated with the workflow component; and changing a representational view of the workflow component from a first representational level to a second representational level when a detail level selector is changed.