Abstract: An immunotherapeutic protein and methods of use and production thereof are disclosed, wherein the immunotherapeutic protein comprises, for example, a cell surface receptor polypeptide which is a cellular entry receptor for the entry of a virus into a host cell, which is linked to a polypeptide comprising an Fc region component. When the cell surface receptor polypeptide is an angiotensin converting enzyme 2 (ACE2) polypeptide or a fragment thereof, the immunotherapeutic protein is capable of binding to a coronavirus spike protein (S protein) and may be useful as an antiviral agent for the prevention or treatment of a coronavirus infection. The Fc region component may comprise an amino acid substitution at the position corresponding to H429 of the amino acid sequence of the human IgG1 heavy chain polypeptide which may enable the production of soluble oligomeric forms or the assembly of oligomeric forms from soluble monomeric forms upon binding to an S protein of a coronavirus (i.e.

Abstract: The present disclosure provides for a tool receiver apparatus for a lawnmower. The apparatus may include a base, a post, an arm, and a sleeve. The base may include a magnet configured for magnetic engagement with a surface of the lawnmower. The post may be disposed on the base and extend upwardly from the base. The arm may extend laterally from the post. The sleeve may be disposed on the arm. The sleeve may include an upper end forming an upper opening, a lower end forming a lower opening, and a passage extending between the upper opening and the lower opening. The sleeve may be configured to receive a tool with a jaw assembly.

Abstract: Immunotherapeutic proteins comprising at least one heavy chain polypeptide derived from an IgG2 antibody are disclosed, wherein the heavy chain polypeptide comprises at least constant heavy domains 2 and 3 (CH2 and CH3) and the lower hinge, and the sequence of the lower hinge comprises a mutation enabling the immunotherapeutic protein to bind to and/or activate Fc?RIIb. The immunotherapeutic protein is suitable for use in methods of treating diseases or conditions wherein, for example, the activation of Fc?RIIb (ie for recruitment of the inhibitory functions of Fc?RIIb) is beneficial, such as allergic diseases.

Abstract: A heating system for an EWOD device using a single, spatially-structured temperature control element, used to create a zone with a specific temperature profile. The heating system uses multiple contact regions between the temperature control element and the device. One or more contact regions are separated from the temperature control element by one or more thermally resistive layers that restrict heat flow from the temperature control element to the device, and further restrict lateral flow of heat between adjacent contact regions. The heating system can use materials with different thermal resistance to alter the heat flow to different regions. The spatial location of the contact regions is also used to determine the temperature profile within the device. The device has an optional temperature control element which offsets the low temperature point from the inlet temperature. This invention includes methods to process multiple droplets within the multiple temperature zones.

Abstract: A method and apparatus for converting DC power to AC power. For example, apparatus for converting DC power to AC power comprises an input adapted to be coupled to a high-powered distributed generator having a maximum voltage at a first voltage and an arc fault mitigation device, coupled to the input, for providing a second voltage at the input that is lower than the first voltage, where a difference between the first voltage and the second voltage is not large enough to cause an arc.

Abstract: Embodiments of planar transformer winding assemblies are provided herein. For example, a transformer winding assembly comprises a primary winding configured to connect to an upper surface of a flexible substrate comprising a plurality of conjoined annular rings, the primary winding runs along the plurality of conjoined annular rings in a first configuration and a secondary winding configured to connect to a lower surface of the flexible substrate, the secondary winding runs along the plurality of conjoined annular rings in a second configuration different from the first configuration.

Abstract: A method and apparatus for converting DC power to AC power. For example, apparatus for converting DC power to AC power comprises an input adapted to be coupled to a high-powered distributed generator having a maximum voltage at a first voltage and an arc fault mitigation device, coupled to the input, for providing a second voltage at the input that is lower than the first voltage, where a difference between the first voltage and the second voltage is not large enough to cause an arc.

Abstract: A zero-turn style lawnmower includes a frame, a foot platform on the frame and a deck positioned below the foot platform. A foot bar spans above the foot platform. The foot bar is attached at one end to a right pedal arm on the right side of the frame and at the opposite end to a left pedal arm on the left side of the frame. The right pedal arm extends upwardly from a right front lift bracket pivotally attached to the right side of the frame, and the left pedal arm extends upwardly from a left front lift bracket pivotally attached to the left side of the frame. A user may press a right foot, left foot or both feet simultaneously on the foot bar to raise or lower the deck.

Abstract: An EWOD device for processing multiple droplets through multiple temperature zones. The device is configured to achieve a high spatial density of temperature zones with a wide temperature difference between hot and cold zones. A first set of temperature control elements is arranged above (or below) a fluid gap in an EWOD device and a second set of temperature control elements is arranged below (or above) the fluid gap. A temperature control element of one set is offset from temperature control elements of the other set in the plane of the fluid gap. The temperature control element of one set may be located at a different separation from the fluid gap to the temperature control element of the other set. The device has an optional temperature control element and/or arrangement which offsets the low temperature point from the inlet temperature. The two sets of temperature control elements are substantially interacting, in the sense that they cannot be considered to be thermally isolated from one another.

Abstract: A method implemented on a dongle device for controlling menu board items on an attached display device includes receiving content for a menu board from an electronic computing device. The menu board content is transferred to the display device for display on the display device. Information is received regarding sales of items listed on the menu board. The information identifies purchasing trends for the items listed on the menu board. A display of the menu board items is dynamically updated based on the identified purchasing trends.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce modeling results such as forecasts of the time series. The pipeline includes a segmentation operation for categorizing the time series into multiple demand classes based on demand characteristics of the time series. The pipeline also includes multiple sub-pipelines corresponding to the multiple demand classes. Each of the sub-pipelines applies a model strategy to the time series in the corresponding demand class. The model strategy is selected from multiple candidate model strategies based on predetermined relationships between the demand classes and the candidate model strategies. The pipeline is executed to determine the modeling results for the time series.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce modeling results such as forecasts of the time series. The pipeline includes a segmentation operation for categorizing the time series into multiple demand classes based on demand characteristics of the time series. The pipeline also includes multiple sub-pipelines corresponding to the multiple demand classes. Each of the sub-pipelines applies a model strategy to the time series in the corresponding demand class. The model strategy is selected from multiple candidate model strategies based on predetermined relationships between the demand classes and the candidate model strategies. The pipeline is executed to determine the modeling results for the time series.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce forecasts. The sequence of operations include model strategy operations for applying various model strategies to the time series to determine error distributions corresponding to the model strategies. The sequence of operations further include a model-strategy comparison operation for determining which of the model strategies is a champion model strategy for the plurality of time series based on the error distributions of the model strategies. The pipeline is executed to determine the champion model strategy for the time series.

Abstract: A pipeline system for time-series data forecasting using a distributed computing environment is disclosed herein. In one example, a pipeline for forecasting time series is generated. The pipeline represents a sequence of operations for processing the time series to produce forecasts. The sequence of operations include model strategy operations for applying various model strategies to the time series to determine error distributions corresponding to the model strategies. The sequence of operations further include a model-strategy comparison operation for determining which of the model strategies is a champion model strategy for the plurality of time series based on the error distributions of the model strategies. The pipeline is executed to determine the champion model strategy for the time series.

Abstract: The present disclosure relates to the use of an at least one soluble Fc binding multimer comprising at least two Fc binding regions to assess FcR binding activity of an at least one polypeptide comprising an Fc region or fragment thereof, including an antibody, and methods and assays of using the Fc binding multimer to assess FcR binding activity. The FcR binding multimer may be a fusion polypeptide comprising an at least two Fc binding regions, or may consist of at least two peptides each comprising at least one Fc binding region, that are covalently or non-covalently oligomerised.

Abstract: A heating system for a EWOD device using a single, spatially-structured temperature control element, used to create a zone on the device with a specific temperature profile. The heating system uses multiple contact regions between the temperature control element and the device. One or more of the contact regions are separated from the temperature control element by one or more thermally resistive layers whose purpose is to restrict heat flow from the temperature control element to the device, and further to restrict lateral flow of heat between adjacent contact regions. The heating system can use one or more materials with different thermal resistance to alter the heat flow to different regions of the device. The spatial location of the contact regions is also used to determine the temperature profile within the device. The device has an optional temperature control element which offsets the low temperature point from the inlet temperature.

Abstract: An EWOD device for processing multiple droplets through multiple temperature zones. The device is configured to achieve a high spatial density of temperature zones with a wide temperature difference between hot and cold zones. A first set of temperature control elements is arranged above (or below) a fluid gap in an EWOD device and a second set of temperature control elements is arranged below (or above) the fluid gap. A temperature control element of one set is offset from temperature control elements of the other set in the plane of the fluid gap. The temperature control element of one set may be located at a different separation from the fluid gap to the temperature control element of the other set. The device has an optional temperature control element and/or arrangement which offsets the low temperature point from the inlet temperature. The two sets of temperature control elements are substantially interacting, in the sense that they cannot be considered to be thermally isolated from one another.

Abstract: A fuel cell stack assembly has a plurality of cells in a stack configuration. Each cell comprises a membrane-electrode assembly disposed between an anode flow plate and a cathode flow plate. A current collector plate is disposed at each end of the stack and a compression assembly maintains the stack under compression. At least one of the current collector plates is formed as a printed circuit board having a first face disposed against a cathode flow plate or an anode flow plate of an outermost cell in the stack and a second face opposite the first face. The first face includes an electrically conductive layer disposed on a substrate of the printed circuit board to serve as a stack current collector electrode. Electrical components such as temperature sensors can be mounted on the printed circuit board such that they lie in or adjacent to a flow channel extending along an adjacent face of the anode or cathode flow plate.

Abstract: Disclosed are systems and methods for controlling animal behavior, such as a dog. In an embodiment, a system can a delivery unit that can include an outer housing, first and second electrodes protruding from a back surface of the outer housing, and a position detection system electrically coupled to the first electrode and the second electrode. The position detection system can include an accelerometer configured to detect one of a predetermined distance of the dog's neck with respect to a ground surface, a predetermined motion of the dog's neck with respect to the ground surface, and a predetermined angle of the dog's neck with respect to a level surface.

Abstract: A LLC bidirectional resonant converter comprising: a resonant tank, a first switching circuit connected to the resonant tank via first power conduits, a second switching circuit connected to the resonant tank via second power conduits, a switching element, and at least one switchable inductive element which is arranged by the switching element to be in parallel across the second power conduits when operating in a first mode of operation and arranged by the switching element to be in parallel across the first power conduits when operating in a second mode of operation.