Abstract: Compounds of formula (1) or (2) and their use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: An in-line, contactless and non-destructive method for detecting and identifying defects in a moving cardboard structure is provided, as well as the associated system. The cardboard structure is of the type made of layered paper plies, such as cardboard tubes for example. The method includes the steps of emitting acoustic waves with predetermined frequencies toward the moving cardboard structure. The acoustic waves are converted into mechanical waves propagating through the moving cardboard structure. The method also includes a step of capturing the acoustic waves propagated, wherein said captured acoustic waves result from a conversion of the propagated mechanical waves through the moving cardboard structure. The method also provides steps of analyzing the captured acoustic waves; and detecting and identifying defects in the moving laminated cardboard structure based on predetermined propagation properties measured from the captured acoustic waves.

Abstract: The present technology relates to a polymer comprising at least one ester repeating unit and one ether repeating unit for use in an electrochemical cell, particularly in electrochemical accumulators such as lithium batteries, sodium batteries, potassium batteries and lithium-ion batteries. More specifically, the use of this polymer as a solid polymer electrolyte (SPE), as a matrix for forming gel electrolytes, or as a binder in an electrode material are also contemplated.

Abstract: A method for extracting at least one foreign body lodged within a blade of a high-pressure distributor of a turbojet engine, the high-pressure distributor including hollow fixed blades between two annular shrouds forming a gas flow path, each blade being coated with a thermal barrier and provided with at least one recess at least partially obstructed by a first soldered closing plate, includes the following operations: cutting off the first closing plate, extracting the foreign body from the recess, carrying out an endoscopic inspection of an internal space of the recess in order to verify that no foreign body remains, positioning a second closing plate on the recess, and soldering the second closing plate directly onto the distributor with the blades coated with the thermal barrier.

Abstract: The invention relates to methods of generating hepatic cells by overexpressing combinations of transcription factors, in particular for use in cellular reprogramming methods.

Abstract: The hybrid measurement system includes an evanescent prism coupling spectroscopy (EPCS) sub-system and a light-scattering polarimetry (LSP) sub-system. The EPCS sub-system includes an EPCS light source optically coupled to an EPCS detector system through an EPCS coupling prism. The LSP sub-system includes an LSP light source optically coupled to an optical compensator, which in turn is optically coupled to a LSP detector system via a LSP coupling prism. A support structure supports the EPCS and LSP coupling prisms to define a coupling prism assembly, which supports the two prisms at a measurement location. Stress measurements made using the EPCS and LSP sub-systems are combined to fully characterize the stress properties of a transparent chemically strengthened substrate. Methods of processing the EPCS and LSP measurements to improve measurement accuracy are also disclosed.

Abstract: The invention relates to an assembly of turbine engine (50) parts having a longitudinal axis (X), the assembly comprising at least two adjacent fan blades made of a 3D woven composite material, each blade (1) comprising a root (3), a vane (2) extending from the root (3), and an integrated platform (4) inserted between the root (3) and the vane (2), the platform (4) extending on either side of the vane (2) and forming a pressure face platform portion (4I) and a suction face platform portion (4E), the pressure face and suction face platform portions of adjacent blades being connected by a fin (14) extending at least radially at the outer side of the pressure face and suction face platform portions (4I, 4E), relative to the longitudinal axis (X), having a substantially triangular transverse cross section and extending axially and so as to upper overlap the longitudinal edges (11A, 11B) of the pressure face and suction face platform portions (4I, 4E) of the adjacent blades.

Abstract: A method for handling and drying cardboard tubes is provided. The method involves using the skids for supporting cardboard tubes during the drying, wrapping and transport of the cardboard tubes, in order to reduce handling of the tubes while maintaining a low moisture level in the tubes.

Abstract: An apparatus is provided for bioprocessing, such as for culturing cells. The apparatus includes a bioreactor with a chamber having cells and a chamber for) temperature regulation of the cells. In some embodiments, a freezer is connected to the bioreactor for freezing the cells in the chamber, and a heater may also be provided for actively thawing the cells. Related methods are also disclosed.

Abstract: The prism-coupling systems and methods include using a prism-coupling system to collect initial TM and TE mode spectra of a chemically strengthened article having a refractive index profile with a near-surface spike region and a deep region. The prism-coupling system has a light source configured to generate sequential measurement light beams or reflected light beams having different measurement wavelengths. The different measurement wavelengths generate different TM and TE mode spectra. The light source can include multiple light-emitting elements and optical filters or a broadband light source and optical filters. The optical filters can be sequentially inserted into either the input optical path or the output optical path of the prism-coupling system.

Abstract: An apparatus for culturing cells includes a bio reactor. The bioreactor may be modular and may include in a chamber a fixed bed, such as an unstructured or structured fixed bed (such as a spiral bed) for culturing cells, with a return column arranged centrally within the chamber. The modular bioreactor may include a plurality of structured fixed beds arranged in a stacked configuration. The modular bioreactor may include an outer casing forming a space for conditioning (e.g., insulating, heating, cooling) at least a chamber in which cells are cultured. The bioreactor may also include an impeller with radially curved blades, and may also suspend the impeller so that it may move from side-to-side and align with an external drive. Related methods are also disclosed.

Abstract: A method of determining a maximum acceptable alternating stress at a point of a part subjected to cyclic loading: simulating that the part is subjected to constant loading equal to a threshold value during a level period, and assuming that the part has elasto-viscoplastic behavior; from the results of the simulation, determining a final static stress at the point at the end or after the end of the level period; and for the point under consideration, using a Goodman diagram to determine the maximum acceptable alternating stress, which is determined for a static stress equal to the final static stress; the duration of the level period being equal to the duration of the loading of the testpieces that were used to draw up the Goodman diagram.

Abstract: A movable ring assembly (4) for a turbine engine turbine (10) that is mounted between two successive rotor discs (20a) and (20b) of said turbine (10), said rotor discs (20a) and (20b) being fixed to each other by bolting, characterised in that it comprises:—a fixing ferrule (44) fixed between the upstream (20a) and downstream (20b) discs by the bolting thereof; a part forming a movable ring (42), said part supporting radial sealing members (32) and being fixed between the upstream disc (20a) and the ferrule (44);—and a seal (46) interposed between said part forming the movable ring (42) and the ferrule (44).

Abstract: A sampler for use with a bioreactor for growing a cell culture is disclosed. In one embodiment, the bioreactor includes a structured fixed bed including a removable sample portion for recovering a sample of cells from the cell culture. Related apparatuses and methods are also disclosed.

Abstract: A corner piece is provided for forming packaging elements. The corner piece includes an inner member and an outer member having respective apexes. A connecting member connects the inner and outer members and substantially aligns their apexes, while spacing the inner and outer members apart from one another. A securing element is provided in the outer member for securing an exterior edge protector along the outer member. The securing element includes substantially U-shaped retaining walls engageable with the exterior edge protector. In some embodiments, the spacing between the inner and outer members defines retaining cavities for securing adjacent sidewalls of a storage container.

Abstract: The hybrid measurement system includes an evanescent prism coupling spectroscopy (EPCS) sub-system and a light-scattering polarimetry (LSP) sub-system. The EPCS sub-system includes an EPCS light source optically coupled to an EPCS detector system through an EPCS coupling prism. The LSP sub-system includes an LSP light source optically coupled to an optical compensator, which in turn is optically coupled to a LSP detector system via a LSP coupling prism. A support structure supports the EPCS and LSP coupling prisms to define a coupling prism assembly, which supports the two prisms at a measurement location. Stress measurements made using the EPCS and LSP sub-systems are combined to fully characterize the stress properties of a transparent chemically strengthened substrate. Methods of processing the EPCS and LSP measurements to improve measurement accuracy are also disclosed.

Abstract: The disclosed technology is generally directed to mixed-reality devices. In one example of the technology, a first mixed-reality guide is provided mixed-reality devices, enabling the mixed-reality devices to operate the first mixed-reality guide while providing a mixed-reality view, such that: while the first mixed-reality guide is navigated to a step of the set of steps of the first mixed-reality guide, the mixed-reality view includes a hologram at a real-world location in the real-world environment at which work associated with the step is to be performed. From each mixed-reality device, mixed-reality data is received based on use of at least the first mixed-reality guide on the mixed-reality device. The mixed-reality data includes spatial telemetry data collected for at least one step of the first mixed-reality guide. A presentation that is based on the mixed-reality data is provided. The first mixed-reality guide is enabled to be altered based on the mixed-reality data.

Abstract: The invention relates to a device (26) for cooling an annular outer turbine casing (17), the device (26) comprising at least one circumferentially extending tube (27) having an air inlet intended for conveying cooling air, said tube (27) having a radially inner wall provided with cooling air discharge openings and a radially outer wall arranged axially opposite each other, an air inlet manifold (28), the inlet of the tube (27) opening into said manifold (28), characterized in that the tube (27) comprises at least one intermediate wall extending over a circumferential portion of the tube (27) from the air inlet, the intermediate wall being located radially between the radially inner wall and the radially outer wall, the radially inner wall and the intermediate wall forming a first air conveying duct, the radially outer wall and the intermediate wall forming a second air conveying duct extending circumferentially beyond the first air conveying duct, relative to the air inlet.

Abstract: A turbomachine comprising a ducted fan, a low-pressure turbine shaft and a reduction gearbox housed in a casing between the fan and the low-pressure turbine shaft, the fan rotor supplying airflow to a primary stream and a secondary stream and comprising a hub of diameter D1, wherein—the diameter D3 of the fan rotor is greater than 82 inches (2.08 metres),—the pressure ratio of the fan is between 1.10 and 1.35, the turbomachine comprises a low-pressure compressor separate from the fan, the reduction gearbox being interposed between the fan rotor and a turbine shaft of the low-pressure compressor, and wherein the reduction gearbox casing has an outside diameter D2 greater than the diameter D1 of the hub, the pitch diameter D4 of the reduction gearbox ring being between 0.15 and 0.35 times the fan rotor diameter.

Abstract: A method for handling and drying cardboard tubes is provided. The method involves using the skids for supporting cardboard tubes during the drying, wrapping and transport of the cardboard tubes, in order to reduce handling of the tubes while maintaining a low moisture level in the tubes.