Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: A medical device for providing guidance to administered cardiopulmonary resuscitation during cardiac arrest in a subject comprising a measuring probe to measure a hemodynamic property of blood flowing through a blood vessel of the subject, an interface element with reference indicia to guide the measuring probe to major blood vessels of the subject experiencing cardiac arrest, and a blood flow monitoring device comprising a data module to collect measured hemodynamic properties of the subject and a guidance module configured to display resuscitation guidance information for manipulating at least one hemodynamic property of the blood.

Abstract: In some embodiments, a blood flow sensor device such as a non-invasive cardiac arrest monitor (NICAM) that uses ultrasound to detect blood flow is used to monitor blood flow during cardiopulmonary resuscitation. One or more gating signal generation devices transmit gating signals to a blood flow monitoring computing device. The blood flow monitoring computing device uses the gating signals to determine time periods during which blood flow information generated by the blood flow sensor device is most likely to be accurate. The blood flow monitoring computing device measures blood flow during the time periods. In some embodiments, the blood flow monitoring computing device presents the measured blood flow to a user. In some embodiments, the blood flow monitoring computing device transmits a command to a chest compression device based on the measured blood flow.

Abstract: A stylet includes a handle assembly with an indicator display and a stiff wire assembly extending distally from the handle assembly having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser, a transmit/receive chip, a bandpass filter, a differential amplifier, an ADC, and an MCU, operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.

Abstract: An example method includes applying ultrasound waves to a particular portion of a nervous tissue. The ultrasound waves are pulsed at a pulse repetition frequency. The method further includes detecting an electrical signal originating from at least the particular portion of the nervous tissue. The method further includes extracting a component of the electrical signal that oscillates at an oscillation frequency that is equal to (a) the pulse repetition frequency, (b) a subharmonic frequency of the pulse repetition frequency, or (c) a harmonic frequency of the pulse repetition frequency. The method further includes processing the extracted component to obtain one or more components that oscillate at respective frequencies that are unequal to the pulse repetition frequency. Systems and computer readable media related to the example method are disclosed herein as well.

Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.

Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Abstract: A medical device for providing guidance to administered cardiopulmonary resuscitation during cardiac arrest in a subject comprising a measuring probe to measure a hemodynamic property of blood flowing through a blood vessel of the subject, an interface element with reference indicia to guide the measuring probe to major blood vessels of the subject experiencing cardiac arrest, and a blood flow monitoring device comprising a data module to collect measured hemodynamic properties of the subject and a guidance module configured to display resuscitation guidance information for manipulating at least one hemodynamic property of the blood.

Abstract: The present invention provides methods, software, and systems for assessing a burn injury.

Abstract: A reperfusion injury detection device comprising a measuring probe with a plurality of sensors collecting a hemodynamic property of a blood vessel of a subject coupled to a pneumatic cuff for applying transient occlusion to the blood vessel being measured and a reperfusion injury analysis device made up from a data module that measures the collected hemodynamic property and determines metric of the measured property over time, and display the measured property on an output module.

Abstract: Described herein are apparatuses and methods for preventing or otherwise reducing scaling and fouling of a membrane using ultrasonic vibrations. One example method involves: (1) directing a solution to a membrane of a membrane assembly, where the membrane passes a solvent of the solution through the membrane at a first rate, and where the membrane prevents at least some of a solute of the solution from passing through the membrane; and (2) causing a piezoelectric material that is physically coupled to the membrane to produce ultrasonic waves directed at the membrane, where the ultrasonic waves induce oscillations in at least a portion of the membrane and thereby the solvent of the solution passes through the membrane at a second rate that is greater than the first rate.

Abstract: A stylet (100) includes a handle assembly (102) with an indicator display (112) and a stiff wire assembly (120) extending distally from the handle assembly (102) having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser (120), a transmit/receive chip (132), a bandpass filter (134), a differential amplifier (136), an ADC (138), and an MCU (140), operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.

Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.

Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.

Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.

Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.

Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.

Abstract: A power toothbrush (10) is disclosed having a handle (15), battery (12), ultrasonic drive circuit (14), motor (16), control unit (18), and toothbrush head (20). The toothbrush head includes bristles (26) and a waveguide (24) that is operatively connected to an ultrasonic transducer (22). The waveguide facilitates the transmission of acoustic energy into the dental fluid to achieve improved cleaning and stain removal and improved cleaning in interproximal and subgingival regions. In one embodiment an ultrasound transducer module (30) includes a plurality of piezoelectric elements (32, 34) that may be mechanically connected in series, and electrically connected in parallel. One or more contacts (36) connect the elements, and a waveguide structure (50). An impedance matching layer (38) may be provided between the waveguide and the ultrasonic transducer module. The waveguide may be formed from a relatively soft material, for example, a polymer having a hardness between 10 and 65 Shore A.

Abstract: A hand-held intra-oral dental device and method are described for the detection of pre-caries lesions and the prediction of evolution and prognosis of same. The present invention has as its foundation a low-cost tool for predicting the likelihood of the development of Early Childhood Caries (ECC), in contrast to other techniques and associated devices, where their focus is to identify individual pre-caries lesions. This method focuses on the detection of caries precursors or of their patterns and the relationship of those precursors and patterns to the likelihood of subsequent dental disease. The implications for the establishment for early preventive treatment are profound, namely the earliest implementation of preventative therapy for our approach relative to that of the other approaches.