Patents by Inventor Pierre D. Mourad
Pierre D. Mourad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7815574Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.Type: GrantFiled: March 31, 2006Date of Patent: October 19, 2010Assignees: PhysioSonics, Inc., University of WashingtonInventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, Alec Rooke
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Publication number: 20100087728Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 8, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Publication number: 20100081893Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 1, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Patent number: 7547283Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.Type: GrantFiled: June 3, 2004Date of Patent: June 16, 2009Assignee: PhysioSonics, Inc.Inventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C. A. Frederickson
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Publication number: 20090149751Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.Type: ApplicationFiled: December 1, 2008Publication date: June 11, 2009Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C.A. Frederickson, R. Lee Thompson, Jason L. Seawall
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Publication number: 20080199957Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: April 18, 2008Publication date: August 21, 2008Applicant: WASHINGTON, UNIVERSITY OFInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
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Patent number: 7374778Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: GrantFiled: May 28, 2004Date of Patent: May 20, 2008Assignees: University of Washington, University of MassachusettsInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
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Patent number: 7296318Abstract: A power toothbrush (10) is disclosed having a handle (15) containing a rechargeable battery (12), an ultrasonic drive circuit (14), a sonic component (16) such as a motor, and a control unit (18). The handle is connected to a toothbrush head (20) preferably having a plurality of bristles (26) and an ultrasonic transducer (22) that is operatively connected to a waveguide (24) that extends from the toothbrush head generally adjacent the bristles. The waveguide facilitates the transmission of acoustic energy into the dental fluid. It is contemplated that the waveguide may be utilized in manual or power toothbrushes, and in a combination without the sonic component, or in a combination without the ultrasonic transducer. Toothbrushes disclosed herein achieve improved plaque and stain removal from the teeth as well as interproximal and subgingival regions, while enhancing the user experience, massaging the gums, and stimulating dental tissue.Type: GrantFiled: November 3, 2004Date of Patent: November 20, 2007Assignee: University of WashingtonInventors: Pierre D. Mourad, Francis G. Olson, Roger Lee Thompson, Jason L. Seawall
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Patent number: 7022077Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.Type: GrantFiled: July 1, 2003Date of Patent: April 4, 2006Assignees: Allez Physionix Ltd., University of WashingtonInventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, Alec Rooke
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Patent number: 6875176Abstract: Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.Type: GrantFiled: November 28, 2001Date of Patent: April 5, 2005Assignees: Aller Physionix Limited, University of WashingtonInventors: Pierre D. Mourad, Michel Kliot, Ali Mesiwala, Rex Patterson, Jeffrey G. Jarvik
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Patent number: 6835393Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: GrantFiled: January 5, 1999Date of Patent: December 28, 2004Assignees: University of Washington, University of MassachusettsInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, David Tirrell, Niren Murthy, Chantal Lackey, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter
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Publication number: 20040059220Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.Type: ApplicationFiled: July 1, 2003Publication date: March 25, 2004Applicants: ALLEZ PHYSIONIX LIMITED, UNIVERSITY OF WASHINGTONInventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, George Alec Rooke
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Patent number: 6444217Abstract: The present invention provides biomedical devices, such as implantable drug delivery devices that possess a surface layer adapted to retain, and controllably release, drug molecules for administration to a subject. The present invention also provides methods of delivering a drug to a subject, the methods utilizing biomedical devices of the invention.Type: GrantFiled: April 25, 2001Date of Patent: September 3, 2002Assignee: University of WashingtonInventors: Connie Sau-Kuen Kwok, Buddy D. Ratner, Pierre D. Mourad, Lawrence A. Crum
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Publication number: 20020095087Abstract: Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke, local edema, infection and vasculitus, as well as diagnosis and monitoring of diseases and conditions that are characterized by physical changes in tissue properties.Type: ApplicationFiled: November 28, 2001Publication date: July 18, 2002Inventors: Pierre D. Mourad, Michel Kliot, Ali Mesiwala, Rex Patterson, Jeffrey G. Jarvik
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Publication number: 20010007666Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: January 5, 1999Publication date: July 12, 2001Inventors: ALLAN S. HOFFMAN, PATRICK STAYTON, OLIVER W. PRESS, DAVID TIRRELL, NIREN MURTHY, CHANTAL LACKEY, LAWRENCE A. CRUM, PIERRE D. MOURAD, TYRONE M. PORTER