Patents by Inventor Pierre L'Host

Pierre L'Host has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5995715
    Abstract: A method and apparatus for printing images wherein printing of individual dots is controlled by employing binary masks. M different complementary binary masks each having the form of a matrix of points occupying N rows and P columns are defined in such a manner that each of the N.times.P elements of a mask has a first binary value or a second binary value, each point of the matrix corresponding to an element having the first binary value in one mask and in one mask only. Each portion of the image is printed in M passes of the print head while using the M different masks in succession, such that during each pass, the print head scans a strip of the print medium, the same mask being used repetitively for each group of P columns and N rows, an image dot being released for printing during a pass when the corresponding element of the mask has the first binary value.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: November 30, 1999
    Assignee: Oce-Technologies B.V.
    Inventors: Stephane Berche, Yifeng Wu, Pierre L. Lermant
  • Patent number: 5814295
    Abstract: The present invention is directed to a method for reliably determining lymph nodes enriched in tumor reactive cells, e.g., CD4+tumor-specific lymphocytes. This method includes the steps of administering to a patient an effective amount of a radiolabeled locator which specifically binds a marker produced by or associated with neoplastic tissue. Time is permitted to elapse following the administration for the radiolabeled locator to preferentially concentrate in any neoplastic tissue and for unbound radiolabeled locator to be cleared, so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in the patient. After the time has elapsed, the patient is accessed with a radiation detection probe for determining lymph node sites exhibiting accretion of the radiolabeled locator by detecting with the probe elevated levels of radiation at the lymph node sites.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: September 29, 1998
    Assignee: The Ohio State University Research Foundation
    Inventors: Edward W. Martin, Jr., Brian J. Czerniecki, Pierre L. Triozzi, Julian A. Kim
  • Patent number: 5782696
    Abstract: In a ball-type joint, the directrix lines (16B) of the grooves (12) of the hub element (3) are defined in such a manner as to provide a groove depth which only slightly varies. The directrix lines (14B) of the grooves (9) of the bell elements are deduced by symmetry relative to a bisecting plane (P) of the joint.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: July 21, 1998
    Assignee: GKN Automotive
    Inventor: Pierre L. Guimbretiere
  • Patent number: 5689152
    Abstract: An electron multiplier of the perforated sheet type includes two successive sheets constituting a dynode which has several multiplier channels in common. For controlling the gain of a given channel (A), a control electrode (30) is provided in the form of a sheet inserted between the sheets (14, 15) of a dynode (Dn) which has a grating window (33) controlling the gain of the channel (A) in question, and one (or several) aperture(s) (34) in accordance with the number of remaining channels. Another channel (B) is controlled by another electrode (31) inserted between the sheets (16, 17) of another dynode (D.sub.n+1). Also disclosed is a multi-channel photomultiplier tube which includes such an electron multiplier.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: November 18, 1997
    Assignee: U.S. Philips Corporation
    Inventors: Jean-Pierre Boutot, Pierre L'Hermite
  • Patent number: 5649671
    Abstract: In a fishing reel with an instantaneously disengageable non-return device, the non-return device has teeth on the inside face of the line recovery device drum. A pawl pivots about an offset spindle on the reel frame and engages with the teeth on the drum in a locked position. A lever pivoting about the main axis of the reel is friction driven by the drum and in turn drives the pawl. The coupling area of the pawl is near the rotation spindle of the pawl and away from the main axis of the reel, so that there is a large multiplication ratio between rotation of the lever and rotation of the pawl. The pawl can therefore be locked to the teeth after imperceptible rotation of the lever and the drum. This achieves an instantaneous non-return function of the drum.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: July 22, 1997
    Assignee: Mitchell Sports
    Inventor: Pierre L'Host
  • Patent number: 5614533
    Abstract: Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an amino acid residue, for example, Val or Ash; R.sup.1 is hydrogen or a ring substituent, for example, fluoro or methyl; R.sup.2 is alkyl; and Y is a ring substituent, for example, phenoxy, 2-pyridinylmethoxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: March 25, 1997
    Assignee: Bio-Mega/Boehringer Ingelheim Research, Inc.
    Inventors: Paul C. Anderson, Fran.cedilla.ois Soucy, Christiane Yoakim, Pierre Lavall ee, Pierre L. Beaulieu
  • Patent number: 5598060
    Abstract: A segmented photomultiplier tube having an electrode which, in its higher part acts as a focusing electrode for distributing photo-electrons on both sides of an axial plane, while in its lower part forming a collection cage, the photo-electrons undergo a first multiplication at the portions of the lateral walls, which are folded towards the axial plane. Apertures in a median plate of the electrode are covered by a highly transparent grid. The electrode is completed by a central partition which extends along the median plate just to the proximity of an input dynode of a laminated multiplier. A bar having a small cross-section may be provided, centered on the axial plane and receiving a potential near the potential across the photocathode. A plurality of these tubes can be arranged in a mosaic pattern for mapping luminous events.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: January 28, 1997
    Assignee: U.S. Philips Corporation
    Inventor: Pierre l'Hermite
  • Patent number: 5574015
    Abstract: Disclosed herein are peptide derivatives of the formula A-B-D-CH.sub.2 CH{CH.sub.2 C(O)R.sup.1 }C(O)-NHCH{CR.sup.2 (R.sup.3)COOH}C(O)-E wherein A is a terminal group, for example an optionally substituted phenylalkanoyl, and B is a N-methyl amino acid residue; or A and B together form a saturated or unsaturated alkylaminocarbonyl; D is an amino acid residue; R.sup.1 is alkyl, cycloalkyl, a monosubstituted or a disubstituted amino; R.sup.2 is hydrogen or alkyl and R.sup.3 is alkyl, or R.sup.2 is hydrogen and R.sup.3 is phenylalkyl, or R.sup.2 and R.sup.3 are joined to form a cycloalkyl; and E is a terminal unit, for example, an alkylamino or a monovalent amino acid radical such as NHCH(alkyl)C(O)OH. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: November 12, 1996
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Pierre L. Beaulieu, Robert D eziel, Neil Moss, Raymond Plante
  • Patent number: 5552405
    Abstract: Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl or an alkanoyl; B is absent or an amino acid residue, for example, Val or Asn; R.sup.1 is alkyl; and Y is a ring substituent, for example, benzyl, benzyloxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: September 3, 1996
    Assignee: Bio-Mega/Boehringer Ingelheim Research, Inc.
    Inventors: Vida Gorys, Fran.cedilla.ois Soucy, Christiane Yoakim, Pierre L. Beaulieu
  • Patent number: 5550291
    Abstract: Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula ##STR1## wherein R.sup.1 and R.sup.2 are amino protective groups and R.sup.3 is an amino acid side chain or a protected amino acid side chain. The synthesis involves reacting an aldehyde of the formula ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined hereinbefore with (chloromethyl)lithium at -20.degree. C. or below and contacting the resulting diastereoisomeric mixture of lithium alcoholates with aqueous hydrochloric acid to obtain a separable mixture of the hydrochloric acid addition salts of the chlorohydrin and its corresponding hydroxy diastereoisomer. The hydrochloric acid addition salt of the chlorohydrin is transformed readily into corresponding optionally amino-protected aminoepoxides; for example, 3(S)-(tert-butyloxycarbonylamino)-l,2(S)-epoxy-4-phenyl-butane.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: August 27, 1996
    Assignee: Bio-Mega/Boehringer Ingelheim Research, Inc.
    Inventors: Pierre L. Beaulieu, Yvan Guindon, Dominik M. Wernic
  • Patent number: 5545640
    Abstract: Disclosed herein are compounds which inhibit human immunodeficiency virus (HIV) protease activity and inhibit HIV replication in human cells. Thus, the compounds are indicated for the treatment of HIV infections. The compounds can be represented by the formula ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an arylalkyl carbamoyl; A is absent or an amino acid or a derived amino acid; either R.sup.1 or R.sup.2 is hydrogen while the other is alkyl or R.sup.1 and R.sup.2 are joined to form a cyclohexane; Q is hydrogen, hydroxy, halo or lower alkoxy; and Y is a terminal group, for example, an alkylamino, alkoxy or an optionally substituted anilino.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: August 13, 1996
    Assignee: Bio-Mega/Boehringer Ingeleheim Research Inc.
    Inventors: Pierre L. Beaulieu, Ingrid Guse
  • Patent number: 5543145
    Abstract: A pharmaceutical composition suitable for administration to human beings for suppressing the production of factor VIII inhibitor includes:an immune complex of factor VIII antigen component and factor VIII inhibitor component, the components being present in a ratio such that the inhibitor blocks essentially all relevant binding sites of the antigen; anda pharmacologically acceptable carrier or diluent. The invention also provides a method of administering the compositions to suppress the production of inhibitor to factor VIII.
    Type: Grant
    Filed: July 21, 1994
    Date of Patent: August 6, 1996
    Assignees: Baxter International, Inc., International Institute of Cellular and Molecular Pathology
    Inventors: Jean-Marie Saint-Remy, Philippe Lebrun, Serge Lebeque, Pierre L. Masson, Henry S. Kingdon
  • Patent number: 5524431
    Abstract: The present invention relates to thrust reversers with doors for jet aircraft engines. The door (2) is equipped, on the internal face of its upstream end, with at least one auxiliary flap (8) articulated to the door and capable of being brought from a position away from the internal face of the door into a position against the latter, and locked in each of these positions by virtue of a control system with link rods (12, 17, 21, 19). The control system is actuated by virtue of its interaction with a stationary stop piece (23). Locking the flap (8) in each of its positions prevents vibration, and damage thereto.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: June 11, 1996
    Assignee: Societe de Construction des Avions Hurel-Dubois
    Inventors: Jean-Pierre Brusson, Jean-Pierre L. Jumel
  • Patent number: 5520514
    Abstract: Assembly for a rotor whose disk alternately bears vanes (1) and platforms (2). The plays (i.e. clearances) (7) are filled up with linings (15) composed of a mainly flexible casing (16) occupied by a small rod (20) which moves outwardly under the action of the centrifugal forces for filling up the play (7).
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: May 28, 1996
    Assignee: Societe Nationale d'Etude et de Construction de Moteurs d'Aviation "SNECMA"
    Inventors: Jean-Pierre L. Mareix, Philippe J.-P. Pabion
  • Patent number: 5502036
    Abstract: Disclosed herein are pentapeptide derivatives of the formula X--NR.sup.1 --CH(R.sup.2)--C(W)--NH--CR.sup.3 (R.sup.4)--C(W.sup.2)--NR.sup.5 --CH CH.sub.2 C(O)--Y!--C(W.sup.3)--NH--CR.sup.6 -- CR.sup.7 (R.sup.8)--COOH!--C(W.sup.4)--NH--CR.sup.9 (R.sup.10)--Z wherein X is a terminal group, for example, alkanoyl or phenylalkanoyl radicals, R.sup.1 is hydrogen, alkyl or phenylalkyl, R.sup.2, R.sup.4 and R.sup.10 are selected from amino acid or derived amino acid residues, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are hydrogen or alkyl or R.sup.7 and R.sup.8 are joined to form a cycloalkyl, W.sup.1, W.sup.2, W.sup.3 and W.sup.4 are oxo or thioxo, Y is, for example, an alkoxy or a mono or disubstituted amino, and Z is a terminal group, for example, COOH or CH.sub.2 OH. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: March 9, 1994
    Date of Patent: March 26, 1996
    Assignee: BioMega Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, Pierre L. Beaulieu, Robert De/ ziel, John DiMaio, Louis Grenier, Pierre Lavalle/ e, Neil Moss
  • Patent number: 5502268
    Abstract: A new method for sealing off a mass of waste which comprises surrounding the mass of waste, stabilized waste or its placement side with a least one substantially continuous layer of porous material, the layer defining a substantially continuous, waste-encompassing interface, and providing a sufficient amount of an interactive reagent on either side of the interface for the reagent upon placement to diffuse towards each other and to form a precipitate filling the pores of the porous material substantially along the interface thereby forming a waste-encompassing layer of reduced permeability. The special benefit of this method is that after a rupture of the seal the interactive reagents form a new seal, thus preventing loss of noxious substances through the rupture.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: March 26, 1996
    Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of the Environment
    Inventors: Pierre L. Co/ te/, Hans A. Van der Sloot
  • Patent number: 5498416
    Abstract: A method for protecting prostheses and temporarily or permanently implantable materials from bacterial colonization and infection, wherein the material is successively impregnated with: (a) a biguanide solution having the general formula (I) ##STR1## wherein R.sub.1 is an alkyl, aminoalkyl, optionally substituted phenyl, naphthyl or cyano radical, R.sub.2 is a hydrogen atom or an alkyl radical and n is an integer from 1-6, with the proviso that the alkyl radicals and portions are linear or branched and contain 1-4 carbon atoms; and (b) a solution of an antibacterial agent which may be gradually redistributed in an aqueous medium; whereafter the material thereby impregnated is dried.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: March 12, 1996
    Inventors: Helene J. Carsenti-Etesse, Pierre L. Dellamonica
  • Patent number: D374891
    Type: Grant
    Filed: September 13, 1995
    Date of Patent: October 22, 1996
    Assignee: Ohio Electronic Engravers, Inc.
    Inventors: Kenneth F. Bornhorst, Jr., Pierre L. Crease, Kim E. Izor, Larry D. Lucous, Larry L. Uptegraph
  • Patent number: D377945
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: February 11, 1997
    Assignee: Ohio Electronic Engravers, Inc.
    Inventors: Kenneth F. Bornhorst, Jr., Pierre L. Crease, Kim E. Izor, Larry D. Lucous, Larry L. Uptegraph
  • Patent number: D381682
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: July 29, 1997
    Assignee: Ohio Electronic Engravers, Inc.
    Inventors: Kenneth F. Bornhorst, Jr., Pierre L. Crease, Kim E. Izor, Larry Dean Lucous, Larry L. Uptegraph