Patents by Inventor Pierre Lestage

Pierre Lestage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8569285
    Abstract: Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing the same which are useful as modulators of the AMPA receptor.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: October 29, 2013
    Assignee: Les Laboratoires Servier
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Publication number: 20120283245
    Abstract: Compounds of formula: wherein: ALK represents an alkylene chain, W represents a group wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in treating cognitive disorders associated with cerebral aging or with neurodegenerative diseases.
    Type: Application
    Filed: December 8, 2010
    Publication date: November 8, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Jean-Michel Henlin, Pierre Lestage, Fany Panayi
  • Patent number: 8236790
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: August 7, 2012
    Assignee: Les Laboratories Servier
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Publication number: 20120071462
    Abstract: Compounds of formula (I): wherein R1 represents a hydrogen atom or a heterocyclic, cyano, alkoxycarbonyl, alkylsulphonylaminoalkyl or N-hydroxycarboximidamide group. Medicinal products containing the same which are useful as modulators of the AMPA receptor.
    Type: Application
    Filed: September 15, 2011
    Publication date: March 22, 2012
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Patent number: 8008337
    Abstract: Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in the treatment of conditions associated with central histaminergic systems.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: August 30, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Pierre Lestage, Fany Panayi
  • Publication number: 20110136886
    Abstract: Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in the treatment of conditions associated with central histaminergic systems.
    Type: Application
    Filed: December 7, 2010
    Publication date: June 9, 2011
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Pierre Lestage, Fany Panayi
  • Patent number: 7906547
    Abstract: Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group selected from wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in the treatment of cognitive and psycho-behavioural disorders associated with cerebral ageing, with neurodegenerative diseases or with cranial traumas and also in the treatment of mood disorders, of schizophrenia and of cognitive disorders associated therewith, of sleep disorders, of sleep-waking rhythm disorders, of attention-deficit hyperactivity syndrome or of obesity.
    Type: Grant
    Filed: June 12, 2009
    Date of Patent: March 15, 2011
    Assignee: Les Laboratoires Servier
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Pierre Lestage, Fany Panayi, Anita Roger
  • Publication number: 20110021569
    Abstract: Compounds of formula (I): wherein: R1 represents a hydrogen atom or a methyl group, R2 represents a bromine atom, a fluorine atom or a trifluoromethyl group. Medicinal products containing the same which are useful in treating cognitive disorders associated with pathologies of the central nervous system.
    Type: Application
    Filed: July 20, 2010
    Publication date: January 27, 2011
    Applicants: LES LABORATOIRES SERVIER, UNIVERSITE, UNIVERSITE DE NANTES
    Inventors: Iuliana Botez, Jacques Lebreton, Pierre Lestage, Caroline Louis, Monique Mathe, Daniel-Henri Caignard
  • Publication number: 20100317698
    Abstract: Compounds of formula (I): wherein: n represents an integer of from 1 to 6 inclusive, X represents an oxygen atom or an NR6 group, Y represents a carbon atom or a nitrogen atom, Z represents a carbon atom or a nitrogen atom, R1 and R2 represent a hydrogen atom or an alkyl or arylalkyl group, R3 and R4 represent a hydrogen atom or an alkyl group, R5 represents a hydrogen atom or an alkyl, halogen, hydroxy, alkoxy, cyano, nitro, acyl, alkoxycarbonyl, trihaloalkyl, trihaloalkoxy or optionally substituted amino group, R6 represents a hydrogen atom or an alkyl or arylalkyl group, Ra, Rb, Rc, Rd and Re are as defined in the description. Medicinal products containing the same which are useful as specific nicotinic ligands of ?4?2 receptors.
    Type: Application
    Filed: January 30, 2007
    Publication date: December 16, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • Publication number: 20100240635
    Abstract: Compounds of formula (I): wherein: R1 and R2, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, acyl, alkoxycarbonyl, carboxy, hydroxy, hydroxyalkyl, cyano, nitro, amino, substituted or unsubstituted aminocarbonyl, aminosulphonyl, alkylsulphonylaminoalkyl, N-hydroxy-carboximidamide or benzyloxy group, R3 represents a hydrogen atom or an alkyl, cycloalkyl or cycloalkylalkyl group, R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator and/or an NMDA receptor antagonist.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 23, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Alexis Cordi, Patrice Desos, Pierre Lestage, Laurence Danober
  • Patent number: 7741320
    Abstract: Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: June 22, 2010
    Assignee: Les Laboratoires Servier
    Inventors: Pierre Francotte, Pascal De Tullio, Bernard Pirotte, Laurence Danober, Pierre Lestage, Daniel-Henri Caignard
  • Publication number: 20100009974
    Abstract: Compounds of formula (I): wherein: RCy represents an unsubstituted or substituted cycloalkyl group or cycloalkylalkyl group, R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen or halogen atom or a nitro group; a cyano group; a hydroxy group; an alkoxy group; an alkyl group; an unsubstituted or substituted amino group; a carboxy group; an alkoxycarbonyl group; an aryloxycarbonyl group; an unsubstituted or substituted aminocarbonyl group. Medicinal products containing the same which are useful in treating or preventing conditions treatable by an AMPA receptor modulator.
    Type: Application
    Filed: July 9, 2009
    Publication date: January 14, 2010
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Pierre FRANCOTTE, Pascal De Tullio, Bernard Pirotte, Laurence Danober, Pierre Lestage, Daniel-Henri Caignard
  • Publication number: 20090312389
    Abstract: Compounds of formula (I): wherein: ALK represents an alkylene chain, W represents a group selected from wherein R and R? are as defined in the description. Medicinal products containing the same which are useful in the treatment of cognitive and psycho-behavioural disorders associated with cerebral ageing, with neurodegenerative diseases or with cranial traumas and also in the treatment of mood disorders, of schizophrenia and of cognitive disorders associated therewith, of sleep disorders, of sleep-waking rhythm disorders, of attention-deficit hyperactivity syndrome or of obesity.
    Type: Application
    Filed: June 12, 2009
    Publication date: December 17, 2009
    Applicant: LES LABORATOIRES SERVIER
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Pierre Lestage, Fany Panayi, Anita Roger
  • Patent number: 7576120
    Abstract: A compound selected from those of formula (I): wherein m and n, which may be identical or different, each represent an integer from 0 to 2 inclusive, with the sum of the two integers being from 2 to 3 inclusive, p and q, which may be identical or different, each represent an integer from 0 to 2 inclusive, Alk represents an alkylene, alkenylene or alkynylene chain, X represents an oxygen atom, a sulphur atom or an —N(R)— group wherein R represents a hydrogen atom or an alkyl group, Y, Y? and W are as defined in the description, its enantiomers, diastereoisomers, and addition salts thereof with one or more pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful for treating conditions associated with central histaminergic systems.
    Type: Grant
    Filed: February 20, 2005
    Date of Patent: August 18, 2009
    Assignee: Les Laboratoires Servier
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Lionel Bert, Pierre Lestage, Brian Lockhart
  • Patent number: 7494994
    Abstract: A compound selected from those of formula (I): wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R4 wherein R3 and R4 are as defined in the description, R2 represents an alkyl, (C3-C8)cycloalkyl or (C3-C8)cycloalkyl-(C1-C6)alkyl group, its isomers, and addition salts thereof, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: February 24, 2009
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Patent number: 7494995
    Abstract: A compound selected from those of formula (I): wherein: R1 represents an NR3SO2R4 group wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents an alkyl group, aryl group or NR5R6 group, R2 represents an alkyl, cycloalkyl or cycloalkylalkyl group, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: February 24, 2009
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Patent number: 7476668
    Abstract: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR? and SO2NHR? wherein R? represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: January 13, 2009
    Assignee: Les Laboratoires Servier
    Inventors: Emmanuel Graindorge, Pierre Francotte, Stéphane Boverie, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Pierre Renard, Daniel-Henri Caignard
  • Patent number: 7423034
    Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: September 9, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alex Cordi, Pierre Lestage
  • Publication number: 20080146621
    Abstract: A compound selected from those of formula (1): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl or (C1-C6)-trihaloalkoxy group or an optionally substituted amino group, R7 represents a hydrogen atom, a (C1-C6)alkyl group or an arylalkyl group, its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Application
    Filed: February 15, 2008
    Publication date: June 19, 2008
    Applicant: LES LABORATORIES SERVIER
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • Patent number: 7388022
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl or (C1-C6)-trihaloalkoxy group or an optionally substituted amino group, R7 represents a hydrogen atom, a (C1-C6)alkyl group or an arylalkyl group, its enatiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: June 17, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage