Patents by Inventor Pierre Lestage

Pierre Lestage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7348344
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom, or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl, (C1-C6)trihaloalkoxy or optionally substituted amino group, its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: March 25, 2008
    Assignee: Les Laboratoires Servier
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • Publication number: 20070270415
    Abstract: The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy, R3 represents unsubstituted or substituted aryl, their isomers, and also addition salts thereof. and medicinal products containing the same which are useful in treating or preventing disorders associated with AMPA flux.
    Type: Application
    Filed: July 27, 2007
    Publication date: November 22, 2007
    Applicant: LESLABORATOIRES SERVIER
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Publication number: 20070249594
    Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
    Type: Application
    Filed: June 27, 2007
    Publication date: October 25, 2007
    Inventors: Patrice Desos, Alex Cordi, Pierre Lestage
  • Patent number: 7268130
    Abstract: The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy, R3 represents unsubstituted or substituted aryl, their isomers, and also addition salts thereof. and medicinal products containing the same which are useful in treating or preventing disorders associated with AMPA flux.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: September 11, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Patent number: 7268129
    Abstract: Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group selected from alkylaminocarbonyl and optionally substituted alkyl, R2 represents hydrogen, halogen or a group selected from cycloalkyl and optionally substituted alkyl, R3 to R6, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, nitro, cyano, alkylsulphonyl, hydroxy, alkoxy, optionally substituted alkyl and optionally substituted amino, its optical isomers when they exist, and also their addition salts with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as AMPA modulators.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: September 11, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Pierre Francotte, Pierre Fraikin, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Daniel-Henri Caignard, Pierre Renard
  • Patent number: 7262189
    Abstract: Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, X represents oxygen or sulphur, Y represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts Medicaments.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: August 28, 2007
    Assignee: Les Laboratoires Server
    Inventors: Alex Cordi, Patrice Desos, Pierre Lestage
  • Patent number: 7262190
    Abstract: The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: August 28, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage, Laurence Danober
  • Patent number: 7262191
    Abstract: The invention relates to compounds of formula (I): wherein: X represents oxygen or sulphur, R1 represents linear or branched (C1-C6)alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy, R3 represents a group R4 or —Y—R5 wherein R4, Y and R5 are as defined in the description, and medicinal products containing the same which are useful in treating or preventing disorders associated with AMPA flux.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: August 28, 2007
    Assignee: Les Laboratories Servier
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Publication number: 20070197625
    Abstract: A compound selected from those of formula (I): wherein m and n, which may be identical or different, each represent an integer from 0 to 2 inclusive, with the sum of the two integers being from 2 to 3 inclusive, p and q, which may be identical or different, each represent an integer from 0 to 2 inclusive, Alk represents an alkylene, alkenylene or alkynylene chain, X represents an oxygen atom, a sulphur atom or an —N(R)— group wherein R represents a hydrogen atom or an alkyl group, Y, Y? and W are as defined in the description, its enantiomers, diastereoisomers, and addition salts thereof with one or more pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful for treating conditions associated with central histaminergic systems.
    Type: Application
    Filed: February 18, 2005
    Publication date: August 23, 2007
    Applicant: Les Laboratoraties Servier
    Inventors: Patrick Casara, Anne-Marie Chollet, Alain Dhainaut, Lionel Bert, Pierre Lestage, Brian Lockhart
  • Patent number: 7253162
    Abstract: Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with the adjacent —CHR3—, forms the ring ?wherein m represents 1, 2 or 3, R5 represents hydrogen or a halogen, X is as defined in the description, their isomers, and also addition salts thereof.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: August 7, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Patrice Desos, Alex Cordi, Pierre Lestage
  • Patent number: 7253161
    Abstract: Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts. Medicaments.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: August 7, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Alex Cordi, Patrice Desos, Pierre Lestage
  • Patent number: 7250411
    Abstract: Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R?CO—O, R, R?, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: July 31, 2007
    Assignee: Les Laboratoires Servier
    Inventors: Alex Cordi, Patrice Desos, Pierre Lestage
  • Publication number: 20070027191
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom, or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl, (C1-C6)trihaloalkoxy or optionally substituted amino group, its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Application
    Filed: July 26, 2006
    Publication date: February 1, 2007
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • Publication number: 20070027192
    Abstract: A compound selected from those of formula (I): wherein: n represents an integer from 1 to 6 inclusive, R1 and R2 represent a hydrogen atom, a (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group, R3 and R4 represent a hydrogen atom or a (C1-C6)alkyl group, R5 and R6 represent a hydrogen atom or a (C1-C6)alkyl, halogen, hydroxy, (C1-C6)alkoxy, cyano, nitro, (C2-C6)acyl, (C1-C6)alkoxycarbonyl, (C1-C6)trihaloalkyl or (C1-C6)-trihaloalkoxy group or an optionally substituted amino group, R7 represents a hydrogen atom, a (C1-C6)alkyl group or an arylalkyl group, its enatiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of conditions requiring a specific nicotinic ligand of ?4?2 receptors.
    Type: Application
    Filed: July 26, 2006
    Publication date: February 1, 2007
    Inventors: Solo Goldstein, Claude Guillonneau, Yves Charton, Brian Lockhart, Pierre Lestage
  • Publication number: 20070004709
    Abstract: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR? and SO2NHR? wherein R? represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
    Type: Application
    Filed: May 4, 2004
    Publication date: January 4, 2007
    Inventors: Pierre Francotte, Stephane Boverie, Pascal De Tullio, Bernard Pirotte, Pierre Lestage, Laurence Danober, Pierre Renard, Daniel-Henri Caignard
  • Publication number: 20060258670
    Abstract: A compound selected from those of formula (I): wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R4 wherein R3 and R4 are as defined in the description, R2 represents an alkyl, (C3-C8)cycloalkyl or (C3-C8)cycloalkyl-(C1-C6)alkyl group, its isomers, and addition salts thereof, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Publication number: 20060258671
    Abstract: A compound selected from those of formula (I): wherein: R1 represents an NR3SO2R4 group wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents an alkyl group, aryl group or NR5R6 group, R2 represents an alkyl, cycloalkyl or cycloalkylalkyl group, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage
  • Publication number: 20060211731
    Abstract: The invention relates to a compound of formula (I): wherein: A represents pyridine, pyridinium, or piperidine, R1, R2, R3 and R4 are as defined in the description R5 represents hydrogen or a group of formula (II): R6 represents hydrogen or linear or branched (C1-C6)alkyl, and medicinal products containing the same which are useful in treating pain or deficiencies in memory.
    Type: Application
    Filed: May 22, 2006
    Publication date: September 21, 2006
    Applicant: LES LABORATORIES SERVIER
    Inventors: Otto Meth-Cohn, Chu-Yi Yu, Pierre Lestage, Marie-Cecile Lebrun, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20060167076
    Abstract: The invention relates to acutumine and compounds thereof and also to compounds of formula (I): wherein R1 and R2 each represent hydrogen or together form an additional bond, R3 represents hydrogen or alkoxy, R5 represents hydrogen or chlorine, R6 represents hydrogen or alkyl, alkylcarbonyl or aroyl, R7 and R10 each represent alkoxy, R10 represents alkoxy, R4, R8, R9, R11, R12, R13 and R14 are as defined in the description. and medicinal products containing the same which are useful in treating deficiencies of memory.
    Type: Application
    Filed: June 16, 2003
    Publication date: July 27, 2006
    Inventors: Guo-Wei Qin, Xi-Can Tang, Pierre Lestage, Daniel-Henri Caignard, Pierre Renard
  • Publication number: 20060128697
    Abstract: The invention relates to compounds of formula (I): wherein R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 15, 2006
    Inventors: Patrice Desos, Alexis Cordi, Pierre Lestage, Laurence Danober