Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.

Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.

Abstract: The invention relates to a method for preparing N-succinimidyl N-biotinyl-6-aminocaproate, characterised in that said method includes a step of activating N-biotinyl-6-aminocaproic acid in the form of a mixed anhydride, followed by coupling said mixed anhydride with N-hydroxysuccinimide.

Abstract: The Invention relates to the methyl pentasaccharide O-2,3,4-tri-O-methyl-?-D-glucopyranosyl-(1?4)-O-2,3-di-O-methyl-?-D-glucopyranosyluronic acid-(1?4)-O-?-D-glucopyranosyl-(1?4)-O-2,3-di-O-méthyl-?-L-idopyranosyluronic acid-(1?4)-O-?-D-glucopyranose in crystallised form, to a method for obtaining the same and to the use thereof for the preparation of idraparinux.

Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0.1 or 2, or X represents CH2, C?O, C?S, CHOH, R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.

Abstract: The invention concerns a method for preparing a-amino acids of general formula (2S-1) wherein: the group R1 represents a hydrogen atom, a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group. The invention also concerns a-amino acids of general formula (2S-1) wherein the group R1 represents a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group and their use as medicine.

Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.

Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.

Abstract: The present invention relates to the use of a compound of formula I: in which, A1 is the radical corresponding to D- or L-Ser, A2 is the radical corresponding to D- or L-Asp or Glu, A3 is the radical corresponding to D- or L-Lys, Arg or Gm, A4 is the radical corresponding to D- or L-Pro, R1 and R2 are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4 being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted; among the substitutions, mention should be made of OH, NH2 or COOH, X1 and X2 are peptide or pseudopeptide bonds, X3 is CO or CH2 and R3 is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4 is a normal or branched C1–C12 hydrocarbon, and Z is H, OH, CO2H or CONH2, or the corresponding tripeptides comprising the radicals A1, A2, A3, and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benef

Abstract: The invention relates to the use of a bigaunide derivative for protecting skin against UVB radiation harmful effects and/or for protecting skin against undesirable and/or inaesthetic effects of UVB radiation.

Abstract: The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom.

Abstract: The invention concerns compounds of formula (I) wherein in particular G represents the —N(CH3)2—, —N(C2H5)2-group or N-pyrrolidine: n is an integer equal to 1 or 2: R1, R2 and R3, independently of one another, represent a hydrogen atom or a methyl group, the successive unsaturated units capable of being moreover identical or different, provided that at least one of the substituents R1, R2, and R3 is different from H: and Y1 and Y2 represent each a —COOCH3 group or a COOC2H5 group.

Abstract: The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH3)2—, —N(C2H5)2-group or N-pyrrolidine: n is an integer equal to 1 or 2: R1, R2 and R3, independently of one another, represent a hydrogen atom or a methyl group, the successive unsaturated units capable of being moreover identical or different, provided that at least one of the substituents R1, R2 and R3 is different from H: and Y1 and Y2 represent each a —COOCH3 group or a —COOC2H5 group.

Abstract: The invention concerns diamines of general formula (I), wherein: A represents a group A1 or A2 of general formula (II); B represents a group B1 or B2 of general formula (III); X represents a SO2, CH2, C?O or COO; YZ represents a group of formula CH(R25)—CH(R26) or CH(R27)?(R28), and R1 to R28, identical or different, represent independently of one another, a hydrogen or halogen atom or an alkyl, cycloalkyl, CN, NO2, hydroxy, aryl, aralkyl, alkoxy, aryloxy, amino, alkylamino, dialkylamino, cycloalkylamino, arylamino, arylalkylamino, diarylamino diarylalkylamino, trihalogenoalkyl or trihalogenoalkoxy group, provided that in the group A1, at least one of the radicals R1, R2, R3, R4 or R5 represents the hydrogen atom when the other four do not represent the hydrogen atom and in the group B1, at least one of the radicals R13, R14, R15, R16 or R17 represents the hydrogen atom when the other four do not represent the hydrogen atom, and their salts with a pharmaceutically acceptable acid, in the form of racemic mixtu

Abstract: The invention concerns a method for preparing a-amino acids of general formula (2S-1) wherein: the group R1 represents a hydrogen atom, a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group. The invention also concerns a-amino acids of general formula (2S-1) wherein the group R1 represents a group protecting the amino group or a group of formula —COOR2 wherein the group R2 represents a C1-C6 alkyl group, an aryl or aralkyl group and their use as medicine.

Abstract: The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form =0, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2) alkoxy group, R6-11 , (C1-C12) alkyl, (CH2)nNR7R8, or —(CH2)nN?R7R8R9 where n?1 to 12 Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.

Abstract: The present invention relates to a method of inhibiting degradation of skin or mucous membranes by inhibiting action of collagenases comprising applying to the skin or mucous membranes a composition comprising at least one of 10-hydroxy-2-decenoic acid derivative. The invention also relates to a process for treating signs of aging.

Abstract: The present invention relates to a highly pure fondaparinux sodium composition, to a process for preparing said composition for its use in pharmaceutical compositions, and also to the pharmaceutical compositions containing it as active principle.

Abstract: The invention relates to a cosmetic composition for topical application containing, in a cosmetically acceptable carrier, an effective quantity of (2S,3R,4S)-4-hydroxyisoleucine and the use of such a composition for combating the natural signs of ageing of the skin and of the scalp.

Abstract: The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ?O, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2)alkoxy group, R6?H, (C1-C12)alkyl, (CH2)nNR7R8, or —(CH2)nN+R7R8R9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.