Abstract: The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 to R.sub.8, which may be identical to or different from each other, have diverse meanings, and the dotted line between the carbon atoms in the 4- and 4a- position or the 4a- and 5-position or the 42- and 12a position may be a single or double bond, or pharmaceutically acceptable salts thereof, as well as a process for the preparation of these compounds, and pharmaceutical compositions containing these compounds. The compounds and their salts are useful for the treatment of heart-circulation disorders.

Abstract: Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-deacetylbaccatine III of general formula (III), R.sub.1, R.sub.2 and R.sub.3 denoting hydroxy-protecting groups, followed by the replacement of the protecting groups by hydrogen.

Abstract: A novel method of relieving pain in warm-blooded animals, including humans, comprising administering to warm-blooded animals an analgesically effective amount of a central analgesic and forskoline simultaneously, separately or at different times and novel analgesic compositions.

Abstract: Derivatives of bicyclic aminocarboxylic acids, a process and intermediates for their preparation, and their use.The invention relates to compounds of the formula ##STR1## in which n is 1-3, R denotes acyl and R.sup.1 denotes an esterifying group or another carboxyl-protecting group, a process and intermediates for their preparation, and their use.

Abstract: Taxol and 10-deacetyltaxol are prepared from a compound of formula: ##STR1## in which R' represents acetyl or 2,2,2-trichloroethoxycarbonyl radical, by removal of the t-butoxycarbonyl radical, benzoylation of the amine product obtained, and removal of the 2,2,2-trichloroethoxycarbonyl group(s).

Abstract: Taxol derivatives of formula ##STR1## in which R represents hydrogen or acetyl, one of R.sub.1 or R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino and their isomers are useful antitumor agents.

Abstract: The substance of formula: ##STR1## called girolline, which is new, can be extracted from the Pseudaxinyssa cantharella sponge. It has remarkable antitumour properties.

Abstract: The present invention relates to a process for the preparation of bis-indolic compounds, and the bis-indolic compounds produced by the process.

Abstract: The present invention relates to a process for the preparation of bis-indolic compounds, and the bis-indolic compounds produced by the process.

Abstract: The invention relates to new chemical compounds.They are compounds corresponding to formula Ia. ##STR1## in which: R'.sub.3 represents a hydrogen atom or a hydroxy radical; R'.sub.5 represents a hydrogen atom or a hydroxy radical; or R'.sub.3 and R'.sub.5 together represent an epoxy bridge or a double bond; R".sub.5 represents a hydrogen atom or an ethyl radical; R'.sub.7 and R'.sub.8 are the same or different and represent a hydrogen atom or a methyl, hydroxymethylene, alkoxymethylene, aryloxymethylene, aminomethylene, monoalkyl or dialkyl aminomethylene, acylmethylene, arylaminomethylene, hydroxyethyl aminomethylene, alkylthiomethylene, aryloxythiomethylene or cyanomethylene radical; R.sub.1 represents a hydrogen atom or an alkyl, formyl or acyl radical: R.sub.2 represents a hydrogen atom or an alkoxy radical; R.sub.7 represents an alkanoyloxy radical, the broken line representing an optional double bond.These compounds can be used as drugs.

Abstract: A process for the preparation of a compound of formula (V) and salts thereof ##STR1## wherein R.sub.1 is selected from the group consisting of a hydrogen atom, an alkyl radical, a formyl radical and an acyl radical;R.sub.2 is selected from the group consisting of an alkoxycarbonyl radical, a hydrazide radical, an acetamido radical, a hydroxymethyl radical, and an alkanoyloxy methyl radicalandR.sub.3 and R.sub.4 are the same or different and each is selected from the group consisting of a hydrogen atom, a hydroxyl radical and an alkanoyloxyl radical;which comprises the step of treating a compound of formula IV ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as previously defined with at least one oxidising agent selected from the group consisting of oxidising metal salts, air and oxygen.The above compounds are useful due to their antitumoral activity, and to their use as intermediates of other antitumor drugs.

Abstract: The invention provides a process for the preparation of leurosidine or vinblastine, which comprises hydroxylating and reducing .DELTA..sup.

Abstract: An improved glass bending device is disclosed for bending and conveying glass sheets. The glass bending device includes a rod having a curved portion, a rotary tubular member engaged about the rod, and a plurality of rings disposed between the rod and the tubular member. In the improvement, the rotary tubular member has internal threading, a plurality of annular support means having external threading are disposed along spaced locations within the tubular member in mating relation with the internal threading thereof, and each of the rings are affixed within one of the annular support means.

Abstract: Pentacyclic derivatives of the general formula ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are defined hereinbelow are useful as cerebral protectors and vasodilators.

Abstract: New compounds having the formula ##STR1## in which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula : ##STR2## in which R is H or C.sub.2 H.sub.5.

Abstract: New compounds having the formula ##SPC1##In which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula: ##SPC2##In which R is H or C.sub.2 H.sub.5.