Patents by Inventor Pietro Massardo

Pietro Massardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6492146
    Abstract: A process for the preparation of phosphatidylserines, comprising the reaction of phosphatides, such as phosphatidylcholine and phosphatidylethanolamine, with racemic or enantiomerically pure Serine, preferably with (L)-Serine, wherein said reaction is carried out in an aqueous dispersion of said phosphatides in the presence of a phospholipase D (PLD) and of calcium salts.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: December 10, 2002
    Assignee: Chemi S.p.A.
    Inventors: Lorenzo De Ferra, Pietro Massardo
  • Patent number: 6444822
    Abstract: Described herein is the process for the preparation of 3-substituted 4-phenyl-piperidine derivatives of formula (I) in which X is selected from H and F, and R is selected from the group consisting of H, C1-C6 alkyl, C3-C6 alkenyl, and benzyl, comprising three steps starting from the monoamide of malonic acid and cinnamic aldehyde, or derivatives thereof.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 3, 2002
    Assignee: Chemi S.p.A.
    Inventors: Lorenzo De Ferra, Pietro Massardo, Oreste Piccolo, Giorgio Cignarella
  • Publication number: 20020103393
    Abstract: The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.
    Type: Application
    Filed: October 18, 2001
    Publication date: August 1, 2002
    Inventors: Lorenzo De Ferra, Pietro Massardo
  • Patent number: 5700668
    Abstract: The invention relates to a process for the preparation of phosphatidylserines by reacting racemic or enantiomerically pure serine, preferably (L)-serine, with natural phosphatides, such as soybean or egg lecithin, or with synthetic phosphatides, in the presence of a phospholipase D, having transphosphatidylating activity, in an aqueous/organic diphasic system.
    Type: Grant
    Filed: December 8, 1995
    Date of Patent: December 23, 1997
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Lorenzo De Ferra, Pietro Massardo, Oreste Piccolo, Stefano Servi
  • Patent number: 5433833
    Abstract: A process for fractionating deacylated glycerophospholipids of the formula (I): ##STR1## wherein R is a negative charge; a hydrogen atom; a CH.sub.2 CH.sub.2 NR.sup.1 R.sup.2 residue wherein R.sup.1 and R.sup.2, which are the same or different, are H or C.sub.1 -C.sub.4 alkyl; a CH.sub.2 CH.sub.2 N.sup.+ (CH.sub.3).sub.3 residue; a CH.sub.2 CH(NH.sub.2)COOH residue or a residue of the formula: ##STR2## and X is OH or 0.sup.-, is described. The process involves subjecting an aqueous or hydroalcoholic mixture of two or more of the deacylated glycerophospholipids to electrodialysis in an electrolytic cell comprising a number of compartments. The compartments are separated by cation-exchange membranes, anion-exchange membranes or both cation-exchange and anion-exchange membranes, at a pH effective to differentiate the deacylated glycerophospholipids.
    Type: Grant
    Filed: May 10, 1994
    Date of Patent: July 18, 1995
    Assignee: Italfarmaco Sud S.p.A.
    Inventors: Lorenzo de Ferra, Sandra Rondinini, Patrizia R. Mussini, Fausto Bonifacio, Pietro Massardo, Oreste Piccolo
  • Patent number: 5315023
    Abstract: A process for the preparation of highly pure deacylated glycerophosphorylcholine, glycerophosphorylethanolamine and glicerophosphorylserine starting from mixtures of the corresponding acylated derivatives.The process according to the invention is characterized in that the deacylation reaction, by means of alcoholysis, and the fractionation are carried out in a single step in a reactor containing a basic ion-exchange resin.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: May 24, 1994
    Assignee: Chemi S.p.A.
    Inventors: Lorenzo De Ferra, Fausto Bonifacio, Guido Cifarelli, Pietro Massardo, Oreste Piccolo
  • Patent number: 5089525
    Abstract: A class of particularly active insecticidal compounds: N-(halobenzoyl)-N'-2-halo-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]-p henyl-ureas, the preparation of such compounds and their use against infestations by insects.
    Type: Grant
    Filed: September 2, 1988
    Date of Patent: February 18, 1992
    Assignee: Istituto Guido Donegani S.p.A.
    Inventors: Pietro Massardo, Giovanni Meazza, Franco Bettarini, Paolo Castoro, Vincenzo Caprioli
  • Patent number: 4980376
    Abstract: Compounds are disclosed having formula: ##STR1## wherein: R is Cl, F;R.sub.1 is H, Cl, F;R.sub.2 and R.sub.5, equal to or differing from each other, are H, halogen, alkyl C.sub.1 -C.sub.4 ;R.sub.3 and R.sub.4, equal to or differing from each other, are: H, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkenyloxy, haloalkenyloxy or alkynyl;Z is O, S or a group NR.sub.7, wherein R.sub.7 is alkyl C.sub.1 -C.sub.3 or H;Y is alkylene C.sub.2 -C.sub.4, haloethylene or haloethenyl;R.sub.6 is alkyl C.sub.1 -C.sub.4, haloalkyl C.sub.1 -C.sub.4, alkenyl C.sub.3 -C.sub.4, haloalkenyl C.sub.3 -C.sub.4, cycloalkyl C.sub.3 -C.sub.4, halocycloalkyl C.sub.3 -C.sub.4 or cycloalkenyl C.sub.3 -C.sub.4.The compounds having formula (I) are endowed with an elevated insecticide activity, which shows itself chiefly against insect larvae and eggs.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: December 25, 1990
    Assignee: Istituto Guido Donegani S.p.A.
    Inventors: Pietro Massardo, Paolo Piccardi, Franco Rama, Vincenzo Caprioli
  • Patent number: 4968847
    Abstract: There is disclosed a process for preparing polyhalogenated carbinols having formula: ##STR1## by reacting a compound having formula: ##STR2## with a system consisting of a compound having formula: ##STR3## and of a divalent metal or of a metal salt, in protic dipolar solvents, in which formulaeR=H, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkadienyl, phenyl, naphthyl, anthracyl group, a heterocyclic radical, optionally substituted;R'=H, a haloalkyl, --CN, --COOR" group with R" equal to H or to an alkyl group;X.sup.1 =Cl, Br; .dbd.X.sup.2 =F, Cl, Br;X.sup.3 =Cl, Br, CF.sub.3, CCl.sub.3 ; Y=Br or Cl when X.sup.1, X.sup.2 and X.sup.3 are different from Br.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: November 6, 1990
    Assignee: Istituto Guido Donegani S.p.A.
    Inventors: Pietro Massardo, Franco Bettarini, Paolo Piccardi, Franco Rama
  • Patent number: 4929772
    Abstract: There is disclosed a process for preparing polyhalogenated carbinols having formula: ##STR1## by reacting a compound having formula: ##STR2## with a system consisting of a compound having formula: ##STR3## and of a divalent metal or of a metal salt, in protic dipolar solvents, in which formulaeR=H, an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkadienyl, phenyl, naphthyl, anthracyl group, a heterocyclic radical, optionally substituted;R'=H, a haloalkyl, --CN, --COOR" group with R" equal to H or to an alkyl group;X.sup.1 =Cl, Br; =X.sub.2 =F, Cl, Br;X.sup.3 =Cl, Br, CF.sub.3, CCl.sub.3 ; Y=Br or Cl when X.sup.1, X.sup.2 and X.sup.3 are different from Br.
    Type: Grant
    Filed: March 9, 1989
    Date of Patent: May 29, 1990
    Assignee: Istituto Guido Donegani
    Inventors: Pietro Massardo, Franco Bettarini, Paolo Piccardi, Franco Rama
  • Patent number: 4902697
    Abstract: Derivatives of 2,2-dimethylcyclopropanecarboxylic acid endowed with insecticidal and acaricidal activity, and having the formula ##STR1## wherein: R is an alkyl, cycloalkyl, alkenyl or alkynyl radical having from 1 to 8 carbon atoms, optionally substituted with halogen atoms, or R is an aryl radical optionally substituted with halogen atoms, alkyl or alkoxyl radicals;Y is O or S;X is H, F, Cl, Br, --CH.sub.3, or --CF.sub.3 ;R.sub.1 represents a group having the formula: ##STR2## wherein: X.sub.1 =H or F; X.sub.2 =H, --CN, or --C.tbd.CH; Q=O or CH.sub.2 ; A=CH or N when X1=H, X2=CN and Q=O.
    Type: Grant
    Filed: August 25, 1987
    Date of Patent: February 20, 1990
    Assignee: Montedison S.p.A.
    Inventors: Luigi Capuzzi, Franco Bettarini, Paolo Castoro, Pietro Massardo, Vincenzo Caprioli
  • Patent number: 4607035
    Abstract: There are described 1-phenoxy(phenylthio)-4-aryl-alkynyloxy-benzene derivatives endowed with a juvenile hormonic activity towards insects and with an acaricide activity. The use of these compounds for controlling insects infestations in both the agrarian and civil field and the processes for preparing said compounds are described too.
    Type: Grant
    Filed: July 22, 1983
    Date of Patent: August 19, 1986
    Assignee: Montedison S.p.A.
    Inventors: Franco Bettarini, Pietro Massardo, Paolo Piccardi, Franca Reggiori, Angelo Longoni
  • Patent number: 4594451
    Abstract: There are described compounds of formula: ##STR1## in which X (or X')=H, F, Cl and X' (or X)=F, Cl; ##STR2## with R.sup.2 =H, Cl, Br, F an optionally halogen-substituted alkyl C.sub.1 -C.sub.3 ;R.sup.3 =halogen, an optionally halogen-substituted alkyl C.sub.1 -C.sub.3 ;R.sup.4 =H or R.sup.3 ;R.sup.1 =H, halogen, an optionally halogen-substituted alkyl C.sub.1 -C.sub.3, OCH.sub.3, SCH.sub.3, OCF.sub.3 ;n=an integer from 1 to 4.The compounds of formula I are endowed with a high insecticide activity which is mainly exerted against insects' larvae and eggs.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: June 10, 1986
    Assignee: Montedison S.p.A.
    Inventors: Pietro Massardo, Franco Bettarini, Gabriele Giovarruscio, Paolo Piccardi, Franca Reggiori, Vincenzo Caprioli, Angelo Longoni
  • Patent number: 4594352
    Abstract: There are described compounds of formula: ##STR1## in which one of R and R.sup.1 is F or Cl and the other is H, F or Cl;X is a 1,4-phenylene or pyridyl bound in positions 2 and 5, optionally substituted;Y is a phenyl, 2- or 3-pyridyl, optionally substituted.The compounds of formula I are endowed with a high insecticide activity which is mainly directed against insect larvae and eggs.
    Type: Grant
    Filed: April 19, 1984
    Date of Patent: June 10, 1986
    Assignee: Montedison S.p.A.
    Inventors: Pietro Massardo, Franco Bettarini, Gabriele Giovarruscio, Paolo Piccardi, Franca Reggiori, Vincenzo Caprioli, Angelo Longoni
  • Patent number: 4540711
    Abstract: There is disclosed a method for fighting infestations of acari or noxious insects including ants, more particularly "fire-ants", by treating the insect, its habitat, or its food with a hydroquinone diether having at least one acetylenic and halogen-substituted chain and selected from 1-[(5-chloro-pent-4-inyl)-oxy]-4-phenoxybenzene of formula ##STR1## and 1,4-di-(5-chloro-4-pentinyloxy)-benzene of formula ##STR2## The disclosure comprises a method for fighting ants using the diether of formula (I) either as such or as an active ingredient of suitable formulations or poisoned baits.
    Type: Grant
    Filed: April 5, 1983
    Date of Patent: September 10, 1985
    Assignee: Montedison S.p.A.
    Inventors: Franco Bettarini, Pietro Massardo, Paolo Piccardi, Angelo Longoni
  • Patent number: 4503042
    Abstract: Acaricide mixtures obtained from the synergistic coupling of an acaricide belonging to the class of the hydroquinone diethers with metallic copper or copper compounds and the use of said mixtures in suitable compositions in the treatment of mite infestations on useful plants are disclosed.
    Type: Grant
    Filed: September 1, 1982
    Date of Patent: March 5, 1985
    Assignee: Montedison S.p.A.
    Inventors: Vincenzo Caprioli, Angelo Longoni, Pietro Massardo
  • Patent number: 4496771
    Abstract: There is described a process for preparing the compound 1-decyloxy-4-[(7-oxa-4-octynyl)-oxy]-benzene consisting in condensing methyl-propargyl-ether with 1-bromo-3-chloro-propane and in reacting the resulting intermediate with 4-decyloxy-phenol in the presence of an alkaline hydroxide.The process can be carried out also without purifying the intermediate obtained from the first reaction.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: January 29, 1985
    Assignee: Montedison S.p.A.
    Inventors: Pietro Massardo, Franco Bettarini, Ennio Bianchini, Paulo Piccardi
  • Patent number: 4460606
    Abstract: A method for fighting infestations by ants is disclosed. It consists in using 1-[(5-chloro-pent-4-inyl)-oxy]-4-phenoxy-benzene either as such or as an active ingredient of compositions or poisoned baits.The present invention concerns a method for fighting infestations by ants and, more particularly, it relates to a fighting method that consists in using, for the purpose, the compound 1-[(5-chloro-pent-4-inyl)-oxy]-4-phenoxy-benzene either as such or in the form of suitable formulations.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: July 17, 1984
    Assignee: Montedison S.p.A.
    Inventors: Franco Bettarini, Pietro Massardo, Paolo Piccardi, Angelo Longoni
  • Patent number: 4388323
    Abstract: There are described hydroquinone-diethers endowed with a high acaricide activity, the processes for their preparation and their use as acaricides.
    Type: Grant
    Filed: March 17, 1981
    Date of Patent: June 14, 1983
    Assignee: Montedison S.p.A.
    Inventors: Pietro Massardo, Angelo Longoni, Paolo Piccardi
  • Patent number: 4356329
    Abstract: There are disclosed two hydroquinone diethers having at least one acetylenic and halogen-substituted chain and exhibiting juvenile hormone and acaricide activity and which show unexpected activity on Tenebrio molitor and Tribolium confusum.The two hydroquinone ethers are obtained by:(a) reacting one mole of hydroquinone alkali metal salt with two moles of 1,5-dichloropent-4-yne, or equimolar quantities of an alkali metal salt of 4-phenoxy-phenol with 1,5-dichlorpent-4-yne; or(b) by reacting the hydroquinone alkali metal salt or the 4-phenoxy-phenol alkali metal salt with the indicated quantities of 1,1,1,5-tetrachloropentane and then dehydrohalogenating the condensation product with alkali metal carbonates or hydroxides in dimethylsulphoxide.
    Type: Grant
    Filed: October 20, 1980
    Date of Patent: October 26, 1982
    Assignee: Montedison S.p.A.
    Inventors: Franco Bettarini, Pietro Massardo, Paolo Piccardi, Angelo Longoni