Patents by Inventor Pil Seok Chae
Pil Seok Chae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884693Abstract: The present invention relates to: amphipathic compounds derived from 1,3-acetonedicarboxylate; a preparation method therefor; and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing membrane proteins by using the same. In addition, the compound enables membrane proteins, which have various structures and characteristics, to be efficiently extracted from cell membranes and stably stored in an aqueous solution for a long time, compared to a conventional compound, thereby being usable in functional and structural analysis thereof. Analyzing the structure and function of membrane proteins is closely related to the development of a novel drug, and thus is one of the greatest interests in the biology and chemistry fields.Type: GrantFiled: October 27, 2022Date of Patent: January 30, 2024Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUSInventors: Pil Seok Chae, Ehsan Muhammad, Ho Jin Lee
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Publication number: 20230279039Abstract: The present invention relates to: amphipathic compounds derived from 1,3-acetonedicarboxylate; a preparation method therefor; and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing membrane proteins by using the same. In addition, the compound enables membrane proteins, which have various structures and characteristics, to be efficiently extracted from cell membranes and stably stored in an aqueous solution for a long time, compared to a conventional compound, thereby being usable in functional and structural analysis thereof. Analyzing the structure and function of membrane proteins is closely related to the development of a novel drug, and thus is one of the greatest interests in the biology and chemistry fields.Type: ApplicationFiled: October 27, 2022Publication date: September 7, 2023Inventors: Pil Seok Chae, Ehsan Muhammad, Ho Jin Lee
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Patent number: 11591306Abstract: The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystallizing a membrane protein using same. By using a compound according to the present invention, not only is an excellent membrane protein extraction and solubilization effect achieved, but the membrane protein can be stably stored for a long period of time in an aqueous solution, and thus the compound can be utilized in analyzing the function and structure of the membrane protein. Moreover, the vitamin E-based amphipathic compounds exhibited superb properties in the visualization of protein compounds through an electron microscope.Type: GrantFiled: February 28, 2018Date of Patent: February 28, 2023Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Ehsan Muhammad
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Patent number: 11524975Abstract: The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope.Type: GrantFiled: February 28, 2018Date of Patent: December 13, 2022Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Aiman Sadaf
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Patent number: 11279726Abstract: Provided are a newly developed norbornene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the same. In addition, the compound may effectively extract membrane proteins having various structures and characteristics, compared to a conventional compound, from cell membranes, and may be stably stored in an aqueous solution for a long period of time, and therefore may be used in their functional analysis and structural analysis. The structural and functional analyses of membrane proteins are the most noticeable field in biology and chemistry today due to a close relationship to the development of new drugs.Type: GrantFiled: February 10, 2017Date of Patent: March 22, 2022Assignee: Industry-Usiversity Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Manabendra Das
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Patent number: 11198704Abstract: A newly developed butane-tetraol-based amphiphilic compound, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the amphiphilic compound are provided. The butane-tetraol-based compound is found to have a central structure exhibiting chirality, and isomers of the compound have clearly different characteristics according to the stereochemistry of the central structure, thereby making it possible to select compounds suitable for the uses thereof. Also, the compound can be used to effectively extract a membrane protein, which has more various structures and characteristics than conventional compounds, from cell membranes and stably store the membrane protein in an aqueous solution for a long time, and thus analyze the function and structure of the membrane protein.Type: GrantFiled: February 10, 2017Date of Patent: December 14, 2021Assignee: Industry—University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Manabendra Das
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Patent number: 10889609Abstract: The present invention relates to a mannitol-based amphipathic compound, a method of preparing the same, a method of extracting, solubilizing, stabilizing or crystallizing a membrane protein using the compound, and a method of analyzing a structure of the membrane protein under an electron microscope using the compound. When the mannitol-based compound according to the present invention is used, the membrane protein can be stably stored in an aqueous solution for a prolonged period of time and thus can be applied to analysis of functions and structures thereof. Since the analysis of the structures and functions of the membrane protein is one of the fields of most interest in biology and chemistry currently, and more than half of new drugs currently in development are targeting membrane proteins, the present invention is applicable to research on the structures of membrane proteins closely related to the development of the new drugs.Type: GrantFiled: December 14, 2015Date of Patent: January 12, 2021Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUSInventors: Pil Seok Chae, Hazrat Hussain
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Patent number: 10808003Abstract: Provided are a newly developed tandem malonate-based amphipathic molecule, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the same. In addition, the compound may be used to efficiently extract membrane proteins having various structures and characteristics from a cell membrane, compared to a conventional compound, to stably store the proteins in an aqueous solution for a long time, and may be used in functional and structural analysis thereof. The analysis of the structures and functions of the membrane proteins is one of the most attractive fields in current biology and chemistry, which are closely related to new drug development.Type: GrantFiled: April 21, 2017Date of Patent: October 20, 2020Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Hazrat Hussain
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Patent number: 10793589Abstract: The present invention relates to a newly developed resorcinarene-based amphipathic compound, a method for producing the same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the same. In addition, compared to a conventional compound, the compound can efficiently extract, from a cell membrane, membrane proteins having a greater variety of structures and characteristics, and can stably store such membrane proteins for a long time in an aqueous solution. Therefore, the compound can be used to analyze the functions and structures of such membrane proteins. Analysis of the structures and functions of membrane proteins, being closely related to the development of new drugs, is one of the fields of greatest interest in biology and chemistry today.Type: GrantFiled: March 17, 2017Date of Patent: October 6, 2020Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Hazrat Hussain
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Publication number: 20200299252Abstract: The present invention relates to a vitamin E-based amphipathic compound, a method for producing same, and a method for extracting, solubilizing, stabilizing, or crystallizing a membrane protein using same. By using a compound according to the present invention, not only is an excellent membrane protein extraction and solubilization effect achieved, but the membrane protein can be stably stored for a long period of time in an aqueous solution, and thus the compound can be utilized in analyzing the function and structure of the membrane protein. Moreover, the vitamin E-based amphipathic compounds exhibited superb properties in the visualization of protein compounds through an electron microscope.Type: ApplicationFiled: February 28, 2018Publication date: September 24, 2020Applicant: Industry-University Cooporation Foundation Hanyang University Erica CampusInventors: Pil Seok CHAE, Ehsan MUHAMMAD
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Patent number: 10781229Abstract: The present invention relates to a TRIS- or neopentyl glycol-based amphipathic compound, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, or crystallizing a membrane protein using the same. By using the TRIS- or neopentyl glycol-based compound according to the present invention, a superior membrane protein solubilization effect is exhibited, a membrane protein can be stably stored for a long time in an aqueous solution, and the structural fluidity of the membrane protein can be excellently maintained. Accordingly, the TRIS- or neopentyl glycol-based compound can be utilized in analyzing functions and structures of membrane proteins. Membrane protein structure and function analysis is currently one of the most attractive fields of research in biology and chemistry. Since more than half of the new drugs under development target membrane proteins, the compound can be applied to membrane protein structure research closely related to drug discovery.Type: GrantFiled: March 3, 2016Date of Patent: September 22, 2020Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Aiman Sadaf
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Publication number: 20200247836Abstract: The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope.Type: ApplicationFiled: February 28, 2018Publication date: August 6, 2020Applicant: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok CHAE, Aiman SADAF
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Patent number: 10647738Abstract: The present invention relates to a xylene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing or crystallizing a membrane protein using the same. By using the xylene-based compound according to the present invention, a membrane protein may be stably stored in an aqueous solution for a long time, and may be applied in functional and structural analyses. The structural and functional analysis of the membrane protein is one of the fields of highest interest in biology and chemistry, and the xylene-based compound according to the present invention can be applied in research on protein structure that is closely related to development of a new drug.Type: GrantFiled: April 15, 2016Date of Patent: May 12, 2020Assignee: Industry-University Cooperation FoundationInventors: Pil Seok Chae, Kyung Ho Cho
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Patent number: 10640527Abstract: The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.Type: GrantFiled: August 31, 2016Date of Patent: May 5, 2020Assignee: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok Chae, Kyung Ho Cho
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Publication number: 20200123187Abstract: A newly developed butane-tetraol-based amphiphilic compound, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the amphiphilic compound are provided. The butane-tetraol-based compound is found to have a central structure exhibiting chirality, and isomers of the compound have clearly different characteristics according to the stereochemistry of the central structure, thereby making it possible to select compounds suitable for the uses thereof. Also, the compound can be used to effectively extract a membrane protein, which has more various structures and characteristics than conventional compounds, from cell membranes and stably store the membrane protein in an aqueous solution for a long time, and thus analyze the function and structure of the membrane protein.Type: ApplicationFiled: February 10, 2017Publication date: April 23, 2020Applicant: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok CHAE, Manabendra DAS
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Publication number: 20200102341Abstract: The present invention relates to a newly developed resorcinarene-based amphipathic compound, a method for producing the same, and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing a membrane protein by using the same. In addition, compared to a conventional compound, the compound can efficiently extract, from a cell membrane, membrane proteins having a greater variety of structures and characteristics, and can stably store such membrane proteins for a long time in an aqueous solution. Therefore, the compound can be used to analyze the functions and structures of such membrane proteins. Analysis of the structures and functions of membrane proteins, being closely related to the development of new drugs, is one of the fields of greatest interest in biology and chemistry today.Type: ApplicationFiled: March 17, 2017Publication date: April 2, 2020Applicant: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok CHAE, Hazrat HUSSAIN
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Publication number: 20200048297Abstract: Provided are a newly developed tandem malonate-based amphipathic molecule, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the same. In addition, the compound may be used to efficiently extract membrane proteins having various structures and characteristics from a cell membrane, compared to a conventional compound, to stably store the proteins in an aqueous solution for a long time, and may be used in functional and structural analysis thereof. The analysis of the structures and functions of the membrane proteins is one of the most attractive fields in current biology and chemistry, which are closely related to new drug development.Type: ApplicationFiled: April 21, 2017Publication date: February 13, 2020Applicant: Industry-University Cooperation Foundation Hanyang University Erica CampusInventors: Pil Seok CHAE, Hazrat HUSSAIN
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Publication number: 20190382434Abstract: Provided are a newly developed norbornene-based amphiphilic compound, a method for preparing the same, and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing a membrane protein using the same. In addition, the compound may effectively extract membrane proteins having various structures and characteristics, compared to a conventional compound, from cell membranes, and may be stably stored in an aqueous solution for a long period of time, and therefore may be used in their functional analysis and structural analysis. The structural and functional analyses of membrane proteins are the most noticeable field in biology and chemistry today due to a close relationship to the development of new drugs.Type: ApplicationFiled: February 10, 2017Publication date: December 19, 2019Applicant: Industry-University Cooperation Foundation Hanyang UniversityInventors: Pil Seok CHAE, Manabendra DAS
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Publication number: 20190284221Abstract: The present invention relates to a TRIS- or neopentyl glycol-based amphipathic compound, a method of preparing the same, and a method of extracting, solubilizing, stabilizing, or crystallizing a membrane protein using the same. By using the TRIS- or neopentyl glycol-based compound according to the present invention, a superior membrane protein solubilization effect is exhibited, a membrane protein can be stably stored for a long time in an aqueous solution, and the structural fluidity of the membrane protein can be excellently maintained. Accordingly, the TRIS- or neopentyl glycol-based compound can be utilized in analyzing functions and structures of membrane proteins. Membrane protein structure and function analysis is currently one of the most attractive fields of research in biology and chemistry. Since more than half of the new drugs under development target membrane proteins, the compound can be applied to membrane protein structure research closely related to drug discovery.Type: ApplicationFiled: March 3, 2016Publication date: September 19, 2019Inventors: Pil Seok CHAE, Aiman SADAF
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Publication number: 20190241597Abstract: The present invention relates to a mesitylene-cored amphiphile, a method of preparing the same and a method of extraction, solubilization, stabilization, crystallization or analysis of a membrane protein using the same. When a mesitylene-cored compound according to the present invention is used, membrane proteins can be stored in a stable conformation for a long time in an aqueous solution in comparison with conventional compounds, by which the membrane proteins are usable in both functional and structural analyses thereof. The functional and structural analyses of membrane proteins are one of the fields that are most spotlighted in current biology and chemistry. The present invention can be used to research on a protein structure closely related to new drug development.Type: ApplicationFiled: August 31, 2016Publication date: August 8, 2019Applicant: Industry-University Cooperation Foundation Hanyang Erica CampusInventors: Pil Seok CHAE, Kyung Ho CHO