Abstract: The present invention discloses an application of inhibitors of glycolytic pathway in preparing drugs for preventing and treating porcine reproductive and respiratory syndrome virus (PRRSV) infection. The present invention found that the inhibitors of glycolytic pathway can be used to prevent and treat PRRSV infection, especially, oral administration of the lactate dehydrogenase inhibitor, sodium oxamate or Galloflavin, can significantly inhibit PRRSV replication in pigs, and the present invention found a new use of the inhibitors of glycolytic pathway, especially the lactate dehydrogenase inhibitor (sodium oxamate or Galloflavin), as a PRRSV antagonist for the first time. The sodium oxamate and Galloflavin have clear anti-PRRSV medicinal ingredients, are quality controllable, safe and non-toxic, and have a good application prospect in prevention and treatment of PRRSV.

Abstract: According to one embodiment, a training device is configured to perform first to third training. The first training includes training a first policy in a simulation environment, the first policy being configured to determine a gripping operation of a robot arm including a gripper. The second training includes training a second policy in a real environment, the second policy being configured to determine the gripping operation of the robot arm. The third training includes training a model configured to output, according to an input of an image, grip information for gripping an object. The second training includes training the second policy by using an output from the first policy and sensor information acquired in the gripping operation. The third training includes training the model by using, as teaching data, a first image of a first environment of reality and grip information output from the second policy.

Abstract: The present invention relates to new aspartic acid ester-functional polysiloxanes, their use in the manufacture of curable compositions using polyisocyanate crosslinkers, in particular, in the manufacture of coating compositions, cured compositions obtained from said curable compositions and articles comprising the cured compositions.

Abstract: Disclosed are a pole piece labeling control method and device, electronic equipment, and a storage medium. The method includes: acquiring a pole piece image, including a pole piece mark hole image, of a target pole piece; determining a defect detection result according to the pole piece image; determining a first distance according to the pole piece mark hole image; determining a second distance according to the first distance; determining a labeling delay of the target pole piece according to the second distance; and controlling the labeling of the target pole piece according to the labeling delay and the defect detection result. The real-time position of the pole piece transferred on a compression roller is identified through the pole piece mark hole image, so that the accuracy of the labeling delay is improved, and the labeling position based on the labeling delay is more accurate.

Abstract: The present disclosure relates to indazole macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer comprising administering a therapeutically effective amount of a compound to a subject in need thereof.

Abstract: A handling apparatus includes a controller and a picking tool for a target object. The controller calculates surface information about a target object by using a first learning model for estimating the surface information from a feature map. The feature map represents a feature of an input image including the target object. The controller identifies surfaces in the input image from the surface information, and transforms the input image into projection images, each being seen from above a point on each of the surfaces in a normal vector direction. The controller calculates, for each projection image, a grasp posture for gripping the target object by using a second learning model. The controller transforms the grasp posture into a grasp posture in a first coordinate system. The controller calculates a final posture of the picking tool by projecting the grasp posture in the first coordinate system onto the input image.

Abstract: A silicone emulsion comprising a (i) a first silicone emulsion comprising a polydiorganopolysiloxane grafted onto colloidal silica; and (ii) a second silicone emulsion comprising an aminosilicone. The silicone emulsion provides improved properties including, but not limited to, one or more of hardness, tensile strength, elongation, and/or thermal stability.

Abstract: A visual detection light source and tab detection equipment are described. The visual detection light source is configured to irradiate a side face of a tab portion, and includes a main light source and a supplementary light source; the main light source and the supplementary light source are arc-shaped light sources, the main light source and the supplementary light source are disposed concentrically, and the main light source is disposed outside the supplementary light source; the main light source is configured to irradiate the side face of the tab portion at an inclined irradiation angle; and the supplementary light source is configured to vertically irradiate the side face of the tab portion.

Abstract: A handling apparatus includes a controller and a picking tool for a target object. The controller calculates surface information about a target object by using a first learning model for estimating the surface information from a feature map. The feature map represents a feature of an input image including the target object. The controller identifies surfaces in the input image from the surface information, and transforms the input image into projection images, each being seen from above a point on each of the surfaces in a normal vector direction. The controller calculates, for each projection image, a grasp posture for gripping the target object by using a second learning model. The controller transforms the grasp posture into a grasp posture in a first coordinate system. The controller calculates a final posture of the picking tool by projecting the grasp posture in the first coordinate system onto the input image.

Abstract: The disclosure belongs to the technical field of high-power laser welding, and discloses a method and system for optimizing process parameters to suppress pores in high-power laser shaping welding. The method includes: obtaining the relationship between the adjustable annular laser beam diameter, the linear energy at the center point, with welding process parameters; and establishing optimization constraint conditions for them; obtaining the preset range of process parameters and substituting parameter values within this range into the optimization constraint conditions; the process parameter combinations that meet both optimization constraint conditions are the optimized process parameters. This disclosure, by flexibly adjusting the power ratio of the central Gaussian beam and the outer annular beam, significantly improves the pore problem in laser welding of aluminum alloys while ensuring large penetration depth, providing reference for high-quality welding of aluminum alloys.

Abstract: This application discloses a tab detection mechanism and a tab detection device. The tab detection mechanism may be configured to detect a tab portion on an electrode core. The tab detection mechanism may include a visual camera; a prism disposed below the visual camera and configured to reflect light on a side surface of the tab portion to the visual camera; and a first driver, connected to the visual camera and configured to drive the visual camera to move in a vertical direction. The visual camera is capable of shooting a plurality of images while moving.

Abstract: A handling apparatus includes a controller and a picking tool for a target object. The controller calculates surface information about a target object by using a first learning model for estimating the surface information from a feature map. The feature map represents a feature of an input image including the target object. The controller identifies surfaces in the input image from the surface information, and transforms the input image into projection images, each being seen from above a point on each of the surfaces in a normal vector direction. The controller calculates, for each projection image, a grasp posture for gripping the target object by using a second learning model. The controller transforms the grasp posture into a grasp posture in a first coordinate system. The controller calculates a final posture of the picking tool by projecting the grasp posture in the first coordinate system onto the input image.

Abstract: According to one embodiment, a determination device is configured to acquire an image of an object to be gripped and input the image to a determination part. The determination device is configured to obtain, from the determination part, an acquisition method of a gripping point. According to the input of the image, the determination part outputs, as the acquisition method, one of a first method, a second method, or a third method. The first method is a method of calculating exterior shape data of the object based on the image and calculating the gripping point by using the exterior shape data. The second method is a method of inputting the image to a second model and acquiring the gripping point output from the second model, the second model being trained. The third method is a method of acquiring the gripping point by the gripping point being designated.

Abstract: A media information processing method and apparatus, a media information playback method and apparatus are disclosed. The media information processing method may include: acquiring media of a plurality of viewpoints, the plurality of viewpoints include at least one real viewpoint and at least one virtual viewpoint, and the media of the at least one virtual viewpoint is generated according to the media of the at least one real viewpoint; generating a media stream according to the media of the plurality of viewpoints, the media stream is a media file including media information; and performing segmentation and packing of the media stream, and generating a Media Presentation Description (MPD) text of the media, the MPD text includes a description of the real viewpoints and a description of the at least one virtual viewpoint, and the MPD text is used for acquiring media stream information of a viewpoint to be played.

Abstract: The invention relates to the technical field of metal material processing engineering, discloses a full-automatic full-process modeling method and system of crystal plasticity finite element model for laser welding weld, which adopts MATLAB to call ABAQUS and PYTHON for co-simulation programming. In this text, a full-automatic modeling method of the crystal plasticity finite element model for laser welding weld is proposed, and a one-key crystal plastic finite element model for laser welding weld is established based on EBSD experimental data. In addition, the full-process full-automatic modeling method of crystal plastic finite element for laser welding weld is universal, and can be used for the establishment of the crystal plasticity finite element model for the microstructure of the base material of aluminum alloy, titanium alloy, magnesium alloy, stainless steel and other materials.

Abstract: Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and disorders. In one example, the products include an additional agent or treatment. Such products can be used in methods for administering the products to treat the hyaluronan-associated diseases and conditions, for example, hyaluronan-associated cancers, for example, hyaluronan-rich tumors. The methods include administration of the hyaluronan degrading enzyme composition alone or in combination with other treatments. Also provided are methods and compositions for providing sustained treatment effects in hyaluronan-associated diseases and conditions.

Abstract: Disclosed is a method and standard module for amplifying pulsed power. The key point of the technical solution is as follows: a method for amplifying pulsed power is formed by means of the joint action of a LASER mode of a crystal medium, a carrier multiplication amplification mode of a semiconductor medium, and a plasma breakdown amplification mode of a gas medium. Electric power which is amplified is converted into optical power first, the optical power is amplified again, and the amplified optical power is converted into electric power again by a photoelectric conversion and amplification device. A gas switch is triggered based on a photoconductive switch to generate a timing-synchronized high-power electric pulse. The high-power electric pulse may be directly outputted or distributed in multiple channels to obtain multiple timing-synchronized trigger signals. In combination with pulse charge of a capacitor, multiple timing-synchronized high-power electric pulses are outputted.

Abstract: Disclosed is a method and standard module for amplifying pulsed power. The key point of the technical solution is as follows: a method for amplifying pulsed power is formed by means of the joint action of a LASER mode of a crystal medium, a carrier multiplication amplification mode of a semiconductor medium, and a plasma breakdown amplification mode of a gas medium. Electric power which is amplified is converted into optical power first, the optical power is amplified again, and the amplified optical power is converted into electric power again by a photoelectric conversion and amplification device. A gas switch is triggered based on a photoconductive switch to generate a timing-synchronized high-power electric pulse. The high-power electric pulse may be directly outputted or distributed in multiple channels to obtain multiple timing-synchronized trigger signals. In combination with pulse charge of a capacitor, multiple timing-synchronized high-power electric pulses are outputted.