Abstract: A system to enable a user to generate copies of files at a client device and to cause a file hosting platform to generate backups of these copies in a cloud database without transferring file content data for these files between the client device and the cloud database. When a user copies a file from a first folder on a client device to a second folder on the client device, the system may determine that the file content data for this file is already present in the cloud database. Then, rather than uploading the file content data to the cloud database from the client device, the system may cause a file hosting platform to access the file content data directly from the cloud database to perform a file copy operation.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e., composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations to support resource isolation and operating system (OS) virtualization functionality. In particular, a container engine interface supports creating, mounting, and providing access to and from composite images or composite containers. In operation, a plurality of files for generating a composite image are accessed. The composite image for the plurality of files is generated. The composite image includes a set of common flat files. The composite image is communicated to cause mounting of the composite image, where mounting the composite image is based on a metadata file from the set of common flat files.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e. composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations to support resource isolation and operating system (OS) virtualization functionality. In particular, a layout manager operates with a composite engine interface to support generating composite images with optimized configurations (i.e., pre-alignment and pre-computed hashes of for executable files). In operation, a plurality of files for generating a composite image are accessed.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e. composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations. In particular, a remote sharing manager operates with a composite engine interface to support generating composite images configured for split layer memory sharing, split layer direct access memory sharing, and dynamic base images. In operation, a plurality of files and a selection of a remote sharing configuration for generating a composite image are accessed. The composite image for the plurality of files and the remoting sharing configuration is generated. The composite image is communicated to cause sharing of the composite image, sharing of the composite image is based on the remote sharing configuration.

Abstract: A first fluidic solution having a first ionic concentration is provided in a first fluidic reservoir in direct fluidic connection with a nanopore. A second fluidic solution, having a second ionic concentration, is provided in a second fluidic reservoir disposed in fluidic connection with the nanopore through a fluidic passage having at least one fluidic section in which the section length is greater than the section width. The electrical potential local to the fluidic passage is measured, and the resistance of both the fluidic passage the nanopore are determined based on the fluidic passage electrical potential. The fluidic passage resistance is compared with the nanopore resistance and at least one of the first and second ionic concentrations is adjusted based on the comparison. The measuring, determining, comparing, and adjusting steps are conducted until the fluidic passage resistance is between about 0.1 times and about 10 times the nanopore resistance.

Abstract: In a method for sensing translocation of a molecule through a nanopore, a molecule in a first fluidic solution in a first fluidic reservoir that is in direct fluidic connection with the nanopore is directed to a nanopore inlet and translocated through the nanopore to a nanopore outlet and through a fluidic passage that is in direct fluidic connection with the nanopore outlet, to a second fluidic solution in a second fluidic reservoir disposed in direct fluidic connection with the fluidic passage. The fluidic passage has at least one fluidic section in which a length of the fluidic section is greater than a width of the fluidic section. Translocation of the molecule through the nanopore is sensed by measuring the electrical potential local to the fluidic passage during the translocation of the molecule.

Abstract: Storage virtualization techniques allow directories to be stored remotely, for example, by a cloud storage provider, but in a manner that appears to a user or application running on a local computing device as if the directories are stored locally—even though the data of those directories may not be resident on the local computing device. That is, the contents of directories that may exist in the cloud look and behave as if they were stored locally on a computing device.

Abstract: A nanopore sensor is provided, including a nanopore disposed in a support structure. A fluidic passage is disposed between a first fluidic reservoir and the nanopore to fluidically connect the first fluidic reservoir to the nanopore through the fluidic passage. The fluidic passage has a passage length that is greater than the passage width. A second fluidic reservoir is fluidically connected to the nanopore, with the nanopore providing fluidic communication between the fluidic passage the second reservoir. Electrodes are connected to impose an electrical potential difference across the nanopore. At least one electrical transduction element is disposed in the nanopore sensor with a connection to measure the electrical potential that is local to the fluidic passage.

Abstract: Systems, methods, and apparatuses are disclosed for file synchronizing service status monitoring and error handling. A client device includes a local file system access manager that includes a status interface. The status interface is configured to receive a status message from a client-side sync manager of the client device. The client-side sync manager that communicates with a server-side sync manager at a server to synchronize data objects between file systems of the client device and server. The status message corresponds to a state of the client-side sync manager during a multi-stage start-up process for the client-side sync manager. A status caller in an application of the client device can retrieve the status message from the status interface. The status message can also be provided to a user interface for display to a user of the client device, and/or to a telemetry server for use in improving the file synchronizing service.

Abstract: Devices for improved nanopore sensing are described. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. The structure can include an array of nanopore structures, each nanopore structure comprising a passage for fluid connection through the structure between the analyte reservoir and outlet chamber. Control terminals can be arranged for applying a control signal to alter the electrical potential difference across that nanopore structure. Some embodiments include an electronic circuit configured to detect a signal from an electrical transduction element at each nanopore structure. Additional structural features and methods of operating and making the devices are described.

Abstract: Determination logic for a cloud content states framework is described herein. In implementations, a framework is configured to perform operations for management of cloud content files at the computing device on behalf of cloud storage providers. Determination logic for the framework is utilized to make state determinations in dependence upon a defined set of file sync properties. The framework operates to make assessments of the file sync properties and set states for files in accordance with the assessments. In implementations, file sync properties are related to corresponding states through a mapping data structure that maps file sync property values to different states and enables look-ups of states based on property values. The framework utilizes and references the mapping data structure to match file sync properties identified for cloud content files to corresponding states and then set states for the cloud content files accordingly.

Abstract: A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.

Abstract: Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown are provided. In one disclosed arrangement a plurality of apertures are formed. The membrane comprises a first surface area portion on one side of the membrane and a second surface area portion on the other side of the membrane. Each of a plurality of target regions comprises a recess or a fluidic passage opening out into the first or second surface area portion. The method comprises contacting all of the first surface area portion of the membrane with a first bath comprising ionic solution and all of the second surface area portion with a second bath comprising ionic solution. A voltage is applied across the membrane via first and second electrodes in respective contact with the first and second baths comprising ionic solutions to form an aperture at each of a plurality of the target regions in the membrane.

Abstract: The present invention discloses a type-G crystal form of fenolamine, a preparation method thereof, and a composition and use thereof. In particular, disclosed is a type-G crystal form of the fenolamine compound (chemical name: trans-2-(2,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-N-(4-hydroxyphenylethyl)acrylamide, a preparation method thereof, and a composition and use thereof. Specifically, the present invention discloses the presence of a solid of a type-G fenolamine crystal form in solid state; a method for preparing the solid of type-G crystal form; and use of the solid of the type-G fenolamine crystal form as a pharmaceutical active ingredient in the manufacture of a medicament for prevention and treatment of Parkinson's disease (PD), improvement of learning and memory disorder, and treatment of memory loss and Alzheimer's disease (AD).

Abstract: Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown are provided. In one disclosed arrangement a plurality of apertures are formed. The membrane comprises a first surface area portion on one side of the membrane and a second surface area portion on the other side of the membrane. Each of a plurality of target regions comprises a recess or a fluidic passage opening out into the first or second surface area portion. The method comprises contacting all of the first surface area portion of the membrane with a first bath comprising ionic solution and all of the second surface area portion with a second bath comprising ionic solution. A voltage is applied across the membrane via first and second electrodes in respective contact with the first and second baths comprising ionic solutions to form an aperture at each of a plurality of the target regions in the membrane.

Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.

Abstract: There is provided a multi-channel nanopore sensor having a plurality of independent nanopore sensors. Each independent nanopore sensor includes a nanopore disposed in a support structure. A fluidic connection is between a first fluidic reservoir, common to all of the independent nanopore sensors, and an inlet to the nanopore, with a first ionic solution of a first ionic concentration disposed in the first fluidic reservoir. A fluidic connection is between a second fluidic reservoir, common to all of the independent nanopore sensors, and an outlet from the nanopore, with a second ionic solution of a second ionic concentration, different than the first ionic concentration, disposed in the second fluidic reservoir. An electrical transduction element, disposed in contact with that ionic solution having a lower ionic concentration, is arranged at a site that produces an electrical signal indicative of electrical potential local to that ionic solution having a lower ionic concentration.

Abstract: A spherical reamer comprises a cutting element having a support member and at least one circumference cutting member built on it. The cutting member can be characterized by edge configuration, geometric parameters or further by positional parameters, respectively. All variations of the parameters above lead various types of the cutting elements and methods of including self- assembling and/or “One Size Cutting Element for Assembling Several Size of Reamers” in order to assembling either reusable or disposable reamer.

Abstract: Systems, methods, and apparatuses are disclosed for file synchronizing service status monitoring and error handling. A client device includes a local file system access manager that includes a status interface. The status interface is configured to receive a status message from a client-side sync manager of the client device. The client-side sync manager that communicates with a server-side sync manager at a server to synchronize data objects between file systems of the client device and server. The status message corresponds to a state of the client-side sync manager during a multi-stage start-up process for the client-side sync manager. A status caller in an application of the client device can retrieve the status message from the status interface. The status message can also be provided to a user interface for display to a user of the client device, and/or to a telemetry server for use in improving the file synchronizing service.

Abstract: A method of preparing liposomal statins includes preparing a lipid solution including phosphatidylcholine, cholesterol, vitamin-E and an organic solvent and removing the solvent, forming a lipid cake. The lipid cake may then be hydrated with a first aqueous media. The hydrated cake may be mixed in a mixer and subjected to one or more freeze/thaw cycles and then extruded to form liposomes. A cryo-protective agent may be added to the liposomes and the liposomes may be lyophilized to provide a powder. A statin is added to the organic lipid solution or to the first aqueous media used for hydrating the lipid cake.