Abstract: A track and hold circuit comprises an input buffer amplifier, a unit gain amplifier module, a sampling switch, a drive triode and a sampling capacitor. The input buffer amplifier receives an input signal. In a track phase, the sampling switch is electrically connected to an emitter electrode of the drive triode; the input signal charges the sampling capacitor after being buffered by the input buffer amplifier, amplified without distortion by the unit gain amplifier module and driven by the drive triode. In a hold phase, the sampling switch is electrically connected to a base electrode of the drive triode; the base voltage of the drive triode is pulled down until the drive triode is cut off; electrical charges on the sampling capacitor are thereby held, causing the signal to be held on the sampling capacitor.

Abstract: The present invention provides methods, systems and devices for drug-drug interaction and adverse event analysis. Chemical structures for one or more pairs of drugs are obtained from at least one of a user and a database. A chemical fingerprint is generated for each drug of the one or more pairs of drugs based on the chemical structure of the drug. Drug-drug interaction prediction is performed for each pair of drugs based on the chemical fingerprints. Adverse event prediction is performed based on the predicted drug-drug interaction for the one or more pairs of drugs.

Abstract: An optical zoom structure includes an amplifying set, a focusing set, and an image display region. The amplifying set resembles the diverging optical effect and includes a first fixed focal set and a first liquid crystal lens. The focusing set resembles a converging optical effect and includes a second fixed focal set and a second liquid crystal lens. The first liquid crystal lens and the second fixed focal set are disposed between the first fixed focal set and the second liquid crystal lens. The first distance is from the first fixed focal set to the first liquid crystal lens. The second distance is from the first liquid crystal lens to the second fixed focal set. The third distance is from the second fixed focal set to the second liquid crystal lens. The fourth distance is from the second first liquid crystal lens to the image display region.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: Provided is a method of eliminating the dependence of methanol induced promoter on a single methanol carbon source for expressing foreign polypeptide. The method comprises activating the expression of the promoter requiring methanol induction by increasing the expression quantity of Mit1 polypeptide in cells of methylotrophic yeast, so that the promoter originally depending on methanol induction no longer depends on single methanol and can also express foreign polypeptide.

Abstract: A ratchet wrench includes a body, a ratchet wheel, a pawl, a ring, a top clip and a bottom clip. The body includes a through hole which defines through the top and the bottom of the body. A top recessed area and a bottom recessed area are respectively defined in the top and the bottom of the body. A recess is defined in the inner periphery of the through hole and a protrusion with a receiving slot extends from one end of the recess. A resilient member is received in the receiving slot to bias the pawl in the recess to engage with the ratchet wheel. The ring is engaged with the top recessed area. The top clip is engaged with the top recessed area and clips the ratchet wheel. The bottom clip is engaged with the bottom recessed area and clips the ratchet wheel.

Abstract: In one embodiment, a method includes receiving one or more datasets including measured vertical electric and magnetic fields excited by one or more radial and azimuthal electric field antennas from a downtool into one or more processors, wherein each of the one or more datasets corresponds to a different position of the one or more radial azimuthal electric field antennas, simultaneously inverting the one or more datasets using the one or more processors, and as a result of the simultaneous inversion, generating by the one or more processors a three-dimensional (3D) image of a portion of the geological formation.

Abstract: A method and apparatus for performing a search in a processor-in-memory (PIM) system having a first processor and at least one memory module includes receiving one or more images by the first processor. The first processor sends a query for a search of memory for a matching image to the one or more images to at least one memory module, which searches memory in the memory module, in response to the received query. The at least one memory module sends the results of the search to the first processor, and the first processor performs a comparison of the received results from the at least one memory module to the received one or more images.

Abstract: A rotating mechanism includes a base, a number of rotating assemblies, and a transmitting assembly. The rotating assemblies are secured on the base. Each rotating assembly includes a rotating table and a limiting assembly assembled to the rotating table. The rotating table of each rotating assembly is substantially collinear and inclined a certain degree relative to a previous rotating table. The limiting assembly defines a channel. The transmitting assembly is received in the channels. When the transmitting assembly moves along the channels, the transmitting assembly is rotated.

Abstract: An embodiment of the invention receives input including a list of drugs, drug characteristics of each drug, and known drug-disease associations including a disease and a drug having a threshold efficacy for treating the disease. For each drug in the list of drugs, a processor predicts whether the drug meets a threshold efficacy for treating a first disease based on the drug characteristics and the drug-disease associations. For each drug in the list of drugs, the processor predicts whether the drug meets a threshold efficacy for treating a second disease based on the drug characteristics and the predicting of whether the drug meets the threshold efficacy for treating the first disease. Output is generated output based on the predictions, the output including an identified drug-disease association, an identified disease-disease association, an identified chemical fingerprint for the first disease, and an identified chemical fingerprint for the second disease.

Abstract: A ratchet wrench includes a head with a ratchet wheel received in the first room in the head. A second room is defined in the inner periphery of the first room. The head has a top closed portion and a bottom closed portion, the second room is located between the top and bottom closed portions. A pawl is located in the second room and a resilient member is biased between the pawl and the inside of the second room so as to engage the pawl with the ratchet wheel. A positioning hole is defined through the top and bottom closed portions. A pin extends through the positioning hole and has a section located in the second room to restrict the movement of the pawl in the second room. The pawl can be made smaller than the pawls used in the conventional ratchet wrenches.

Abstract: Embodiments include method, systems and computer program products for predicting adverse drug events on a computational system. Aspects include receiving known drug data from drug databases and one or more of a candidate drug, a drug pair, and a candidate drug-patient pair. Aspects also include calculating an adverse event prediction rating representing a confidence level of an adverse drug event for the candidate drug, a drug pair, and a candidate drug-patient pair, the rating being based on the known drug data. Aspects also include associating adverse event features with the candidate drug, drug pair, or a candidate drug-patient pair, including a nature, cause, mechanism, or severity of the adverse drug event. Aspects also include calculating and outputting an adverse event prediction rating.

Abstract: Embodiments include method, systems and computer program products for predicting adverse drug events on a computational system. Aspects include receiving known drug data from drug databases and one or more of a candidate drug, a drug pair, and a candidate drug-patient pair. Aspects also include calculating an adverse event prediction rating representing a confidence level of an adverse drug event for the candidate drug, a drug pair, and a candidate drug-patient pair, the rating being based on the known drug data. Aspects also include associating adverse event features with the candidate drug, drug pair, or a candidate drug-patient pair, including a nature, cause, mechanism, or severity of the adverse drug event. Aspects also include calculating and outputting an adverse event prediction rating.

Abstract: The present application provides polyanionic and non-ionic cyclodextrin-based compounds, and methods of manufacturing them. The compounds comprise a negatively-charged or neutral moiety (and, for polyanionic compounds, a suitable counter cation), one or more linkers, optionally one or more bridging groups, a cyclodextrin, and one or more substituents on the cyclodextrin. The compounds can be used in pharmaceutical compositions, and as excipients or carriers of guest molecules.

Abstract: Well trajectory adjustment is provided. In one possible implementation, an initial 3D model of a portion of a formation in which a well is being drilled is accessed. Subsurface data associated with the formation is then used to tune the initial 3D model to create a revised 3D model. In another possible implementation, subsurface data associated with a formation in which a well is being drilled is used to tune an initial 3D model of the formation to create a revised 3D model. An initial planned trajectory of the well can also be adjusted to reach a sweet spot in the revised 3D model.

Abstract: A system and method for analyzing chemical data including a processor and one or more classifiers, stored in memory and coupled to the processor, which further includes an indication predictive module configured to predict whether a given chemical treats a particular indication or not and a side effect predictive module configured to predict whether a given chemical causes a side-effect or not. A correlation engine is configured to determine one or more correlations between one or more indications and one or more side effects for the given chemical and a visualization tool is configured to analyze the one or more correlations and to output results of the analysis.

Abstract: A system and method for analyzing chemical data including a processor and one or more classifiers, stored in memory and coupled to the processor, which further includes an indication predictive module configured to predict whether a given chemical treats a particular indication or not and a side effect predictive module configured to predict whether a given chemical causes a side-effect or not. A correlation engine is configured to determine one or more correlations between one or more indications and one or more side effects for the given chemical and a visualization tool is configured to analyze the one or more correlations and to output results of the analysis.

Abstract: A shower head with rotary bottom cover assembly includes a water passage member with a third inlet and an outlet chamber communicating with each other, a rotator mounted inside the outlet chamber and having a first rotator inlet, a first outlet and a diverting channel, a rotator cover, a bottom cover assembly. The first rotator inlet is mounted inside the third inlet of the water passage member and communicates with a center portion of the diverting channel. The diverting channel has two second outlets formed on two ends thereof and oppositely located. The rotator cover hermetically covers and seals the outlet chamber and has a hole for an outlet hose to be mounted through. A top of the outlet hose is connected with the center portion of the diverting channel. A bottom of the outlet hose engages the bottom cover assembly. The water head is structurally simple and has massaging effect.

Abstract: The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.