Patents by Inventor Piyasena Hewawasam

Piyasena Hewawasam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of hepatitis C
    Patent number: 7994171
    Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: August 9, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kap-Sun Yeung, Kyle E. Parcella, John A. Bender, Brett R. Beno, Katharine A. Grant-Young, Ying Han, Piyasena Hewawasam, John F. Kadow, Andrew Nickel
  • Hepatitis C Virus Inhibitors
    Publication number: 20110077280
    Abstract: This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.
    Type: Application
    Filed: March 23, 2010
    Publication date: March 31, 2011
    Inventors: John A. Bender, Piyasena Hewawasam, John F. Kadow, Omar D. Lopez, Nicholas A. Meanwell, Van N. Nguyen, Jeffrey Lee Romine, Lawrence B. Snyder, Denis R. St. Laurent, Gan Wang, Ningning Xu, Makonen Belema
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20100249094
    Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Application
    Filed: March 10, 2010
    Publication date: September 30, 2010
    Inventors: Kap-Sun Yeung, Kyle E. Parcella, John A. Bender, Brett R. Beno, Katharine A. Grant-Young, Ying Han, Piyasena Hewawasam, John F. Kadow, Andrew Nickel
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20100184800
    Abstract: The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Application
    Filed: March 9, 2010
    Publication date: July 22, 2010
    Inventors: Richard Pracitto, John F. Kadow, John A. Bender, Brett R. Beno, Katharine A. Grant-Young, Ying Han, Piyasena Hewawasam, Andrew Nickel, Kyle E. Parcella, Kap-Sun Yeung, Louis S. Chupak
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20100093694
    Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Application
    Filed: September 4, 2009
    Publication date: April 15, 2010
    Inventors: Kap-Sun Yeung, Kyle E. Parcella, John A. Bender, Brett R. Beno, Katharine A. Grant-Young, Ying Han, Piyasena Hewawasam, John F. Kadow, Andrew Nickel
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20100063068
    Abstract: The disclosure provides compounds of formula I, II, III, IV, and V, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 11, 2010
    Inventors: Richard Pracitto, John F. Kadow, John A. Bender, Brett R. Beno, Katharine A. Grant-Young, Ying Han, Piyasena Hewawasam, Andrew Nickel, Kyle E. Parcella, Kap-Sun Yeung, Louis S. Chupak
  • Hepatitis C virus inhibitors
    Patent number: 7601686
    Abstract: The present disclosure relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, Min Ding, Li-Qiang Sun, Paul Michael Scola
  • Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
    Publication number: 20090162318
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: February 25, 2009
    Publication date: June 25, 2009
    Inventors: John A. Bender, Min Ding, Robert G. Gentles, Piyasena Hewawasam
  • Compounds for the treatment of Hepatitis C
    Patent number: 7547690
    Abstract: The invention encompasses compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: June 16, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the treatment of hepatitis C
    Patent number: 7541353
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: June 2, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Xiaofan Zheng, Min Ding, Yong Tu, Ying Han, Piyasena Hewawasam, John F. Kadow, John A. Bender, Kap-Sun Yeung, Katharine A. Grant-Young, Thomas W. Hudyma
  • Compounds for the treatment of Hepatitis C
    Patent number: 7538102
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 26, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kap-Sun Yeung, John A. Bender, Robert G. Gentles, Zhong Yang, Min Ding, Yong Tu, Piyasena Hewawasam, Ying Han, John F. Kadow
  • Compounds for the treatment of hepatitis C
    Patent number: 7538103
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: May 26, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, Yong Tu
  • Compounds for the Treatment of Hepatitis C
    Publication number: 20090130057
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Application
    Filed: November 18, 2008
    Publication date: May 21, 2009
    Inventors: Piyasena Hewawasam, Yong Tu, John A. Bender, Zhong Yang
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7521442
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Min Ding, Piyasena Hewawasam
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7521443
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: John A. Bender, Min Ding, Robert G. Gentles, Piyasena Hewawasam
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7521441
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 7, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert G. Gentles, Piyasena Hewawasam, Min Ding, Carl P. Bergstrom, Scott W. Martin, Kap-Sun Yeung, Thomas W. Hudyma, Xiaofan Zheng, John A. Bender, John F. Kadow
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7485633
    Abstract: The invention encompasses compounds of Formula I, pharmaceutically acceptable salts thereof, compositions, and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: March 12, 2007
    Date of Patent: February 3, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Nicholas A. Meanwell, Robert G. Gentles, Min Ding, John A. Bender, John F. Kadow, Piyasena Hewawasam, Thomas W. Hudyma, Xiaofan Zheng
  • Indolobenzazepine HCV NS5B inhibitors
    Patent number: 7473688
    Abstract: The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: January 6, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Carl P. Bergstrom, John A. Bender, Robert G. Gentles, Piyasena Hewawasam, Thomas W. Hudyma, John F. Kadow, Scott W. Martin, Alicia Regueiro-Ren, Kap-Sun Yeung, Yong Tu, Katharine A. Grant-Young, Xiaofan Zheng
  • Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
    Patent number: 7456166
    Abstract: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: John A. Bender, Min Ding, Robert G. Gentles, Piyasena Hewawasam
  • Hepatitis C virus inhibitors
    Patent number: 7449479
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: November 11, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiangdong Alan Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Piyasena Hewawasam, Andrew Charles Good, Yan Chen, Jeffrey Allen Campbell