Patents by Inventor Po-Wai Yuen

Po-Wai Yuen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20180291000
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
    Type: Application
    Filed: June 14, 2018
    Publication date: October 11, 2018
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Bingsong Han, Jian Lin, Dominic J. Reynolds, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng, Po-Wai Yuen
  • SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
    Publication number: 20180282272
    Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
    Type: Application
    Filed: June 6, 2018
    Publication date: October 4, 2018
    Applicant: Genentech, Inc.
    Inventors: Huifen CHEN, Yanyan CHU, Steven DO, Anthony ESTRADA, Baihua HU, Aleksandr KOLESNIKOV, Xingyu LIN, Joseph P. LYSSIKATOS, Daniel SHORE, Vishal VERMA, Lan WANG, Guosheng WU, Po-wai YUEN
  • THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20180265515
    Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
    Type: Application
    Filed: May 22, 2018
    Publication date: September 20, 2018
    Applicant: Genentech, Inc.
    Inventors: Yun-Xing Cheng, Paul Gibbons, Terry Kellar, Wei Li, Rohan Mendonca, Po-wai Yuen, Mark Edward Zak, Lei Zhang
  • THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF
    Publication number: 20180244694
    Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 30, 2018
    Applicant: Genentech, Inc.
    Inventors: Yu Jiang, Guosheng Wu, Po-Wai Yuen, Elisia Villemure, Jacob Schwarz, Cuong Ly, Benjamin Sellers, Matthew Volgraf
  • Thiazolopyrimidinones and methods of use thereof
    Patent number: 9988400
    Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: June 5, 2018
    Assignee: Genentech, Inc.
    Inventors: Yu Jiang, Guosheng Wu, Po-Wai Yuen, Elisia Villemure, Jacob Schwarz, Cuong Ly, Benjamin Sellers, Matthew Volgraf
  • SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
    Publication number: 20180118680
    Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
    Type: Application
    Filed: December 21, 2017
    Publication date: May 3, 2018
    Applicant: Genentech, Inc.
    Inventors: Huifen Chen, Yanyan Chu, Steven Do, Anthony Estrada, Baihua Hu, Aleksandr Kolesnikov, Xingyu Lin, Joseph P. Lyssikatos, Daniel Shore, Vishal Verma, Lan Wang, Guosheng Wu, Po-wai Yuen
  • Triazolopyridine compounds, compositions and methods of use thereof
    Patent number: 9873709
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: January 23, 2018
    Assignee: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
    Publication number: 20170368039
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Application
    Filed: November 15, 2016
    Publication date: December 28, 2017
    Applicants: Forma TM, LLC, Genentech, Inc.
    Inventors: BAIR W. Kenneth, Timm R. BAUMEISTER, Alexandre J. BUCKMELTER, Karl H. CLODFELTER, Peter DRAGOVICH, Francis GOSSELIN, Bingsong HAN, Jian LIN, Dominic J. REYNOLDS, Bruce ROTH, Chase C. SMITH, Zhongguo WANG, Po-Wai YUEN, Xiaozhang ZHENG
  • Amido spirocyclic amide and sulfonamide derivatives
    Patent number: 9822129
    Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: November 21, 2017
    Assignees: Genentech, Inc., Forma TM, LLC
    Inventors: Kenneth W Bair, Timm R Baumeister, Peter Dragovich, Xiongcai Liu, Snahel Patel, Po-Wai Yuen, Mark Zak, Guiling Zhao, Yamin Zhang, Xiaozhang Zheng
  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170226132
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES
    Publication number: 20170216262
    Abstract: Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: March 29, 2017
    Publication date: August 3, 2017
    Inventors: Kenneth W. BAIR, Timm R. BAUMEISTER, Peter DRAGOVICH, Xiongcai LIU, Snahel PATEL, Po-Wai YUEN, Mark ZAK, Guiling ZHAO, Yamin ZHANG, Xiaozhang ZHENG
  • ALKYNYL ALCOHOLS AND METHODS OF USE
    Publication number: 20170210724
    Abstract: The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicole Blaquiere, Georgette Castanedo, Jianwen A. Feng, Baihua Hu, Steven Staben, Po-wai Yuen, Guosheng Wu, Xingyu Lin, Jason Burch
  • ALKYNYL ALCOHOLS AND METHODS OF USE
    Publication number: 20170145034
    Abstract: The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: February 6, 2017
    Publication date: May 25, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicole Blaquiere, Georgette Castanedo, Jianwen A. Feng, Baihua Hu, Steven Staben, Po-wai Yuen, Guosheng Wu, Jason Burch
  • Alkynyl alcohols and methods of use
    Patent number: 9605005
    Abstract: The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: March 28, 2017
    Assignee: Genentech, Inc.
    Inventors: Nicole Blaquiere, Georgette Castanedo, Jianwen A. Feng, Baihua Hu, Steven Staben, Po-wai Yuen, Guosheng Wu, Jason Burch
  • PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES
    Publication number: 20160355514
    Abstract: Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
    Type: Application
    Filed: August 22, 2016
    Publication date: December 8, 2016
    Inventors: Kenneth W. BAIR, Timm R. BAUMEISTER, Peter DRAGOVICH, Francis GOSSELIN, Po-Wai YUEN, Mark ZAK, Xiaozhang ZHENG
  • Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives
    Patent number: 9458172
    Abstract: Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: October 4, 2016
    Inventors: Kenneth W Bair, Timm R Baumeister, Peter Dragovich, Francis Gosselin, Po-Wai Yuen, Mark Zak, Xiaozhang Zheng
  • SUBSTITUTED SULFONAMIDE COMPOUNDS
    Publication number: 20160264567
    Abstract: The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.
    Type: Application
    Filed: February 12, 2016
    Publication date: September 15, 2016
    Applicant: Genentech, Inc.
    Inventors: Po-wai YUEN, Anthony ESTRADA, Huifen CHEN, Aleksandr KOLESNIKOV, Elisia VILLEMURE, Vishal VERMA, Lan WANG, Daniel SHORE, Steven DO, Matthew VOLGRAF, Baihua HU, Guosheng WU, Xingyu LIN, Aijun LU
  • THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF
    Publication number: 20160222033
    Abstract: The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 4, 2016
    Applicant: Genentech, Inc.
    Inventors: Jiang Yu, Guosheng Wu, Po-Wai Yuen, Elisia Villemure, Jacob Schwarz, Cuong Ly, Benjamin Sellers, Volgraf Matthew
  • SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
    Publication number: 20160221945
    Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
    Type: Application
    Filed: April 11, 2016
    Publication date: August 4, 2016
    Applicant: GENENTECH, INC.
    Inventors: Huifen CHEN, Yanyan CHU, Steven DO, Anthony ESTRADA, Baihua HU, Aleksandr KOLESNIKOV, Xingyu LIN, Joseph P. LYSSIKATOS, Daniel SHORE, Vishal VERMA, Lan WANG, Guosheng WU, Po-wai YUEN
  • ALKYNYL ALCOHOLS AND METHODS OF USE
    Publication number: 20160200739
    Abstract: The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
    Type: Application
    Filed: March 18, 2016
    Publication date: July 14, 2016
    Applicant: Genentech, Inc.
    Inventors: Nicole Blaquiere, Georgette Castanedo, Jianwen A. Feng, Baihua Hu, Steven Staben, Po-wai Yuen, Guosheng Wu, Jason Burch