Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.

Abstract: Various aspects can be implemented for detecting name entities and/or new words from input entries. In general, one aspect can be a method that includes receiving an input entry comprising a text string. The method also includes identifying segmentation information from the input entry. The method further includes generating a candidate text string from the text string of the input entry based on the segmentation information. Other implementations of this aspect includes corresponding systems, apparatus, and processing engines.

Abstract: The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.

Abstract: Context signals in documents are identified, characters bounded by the context signals are identified, one or more candidate words defined by the characters bounded by the context signals are identified, and one or more of the candidate words are added to an input method editor dictionary.

Abstract: Candidate words in search queries are identified, each candidate word including one or more consecutive characters. For each candidate word, a first count is determined, the first count representing a number of times that the candidate word is the only word in the search queries, and a second count is determined, the second count representing a number of times that the candidate word and one or more other words are included in each of the search queries. One or more of the candidate words are added to an input method editor dictionary based on a relationship between the first count and the second count.

Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.

Abstract: This invention relates resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof.

Abstract: The present invention provides methods for identifying test substances that bind to the ?2? subunit of a calcium channel.

Abstract: The invention provides an assay system for detecting a molecule that interacts with a membrane channel, the assay system including cell membranes including one or more membrane channels; support bodies including scintillant and a coupling agent that associates with the cell membrane; a ligand that is selected to bind the membrane channel, the ligand including a scintillant-activating label. According to the invention, association of the support bodies with the cell membrane and binding of the ligand to the membrane channel results in emission from the scintillant of the support bodies, and, in the presence of a test molecule that interacts with the membrane channel, the emission from the scintillant of the support bodies changes. Methods of identifying a molecule that interacts with a cell membrane channel are also described.

Abstract: The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent number of RTX binding sites were decreased with increasing pH from 8.6 to 10.6. The high pH may be causing the cell membranes to denature. These pH conditions (pH 8.0 to pH 9.0) provide a high signal to noise ratio, give a more robust assay and require use of less experimental materials.

Abstract: The present invention provides methods for identifying test substances that bind to the ?2? subunit of a calcium channel.

Abstract: The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.

Abstract: This invention relates to resiniferatoxin derivatives useful in a vanilloid receptor binding assay and methods for production thereof.

Abstract: The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent number of RTX binding sites were decreased with increasing pH from 8.6 to 10.6. The high pH may be causing the cell membranes to denature. These pH conditions (pH 8.0 to pH 9.0) provide a high signal to noise ratio, give a more robust assay and require use of less experimental materials.

Abstract: The present invention provides methods for identifying test substances that bind to the &agr;2&dgr; subunit of a calcium channel.

Abstract: The present invention provides methods for identifying test substances that bind to the &agr;2&dgr; subunit of a calcium channel.

Abstract: The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent number of RTX binding sites were decreased with increasing pH from 8.6 to 10.6. The high pH may be causing the cell membranes to denature. These pH conditions (pH 8.0 to pH 9.0) provide a high signal to noise ratio, give a more robust assay and require use of less experimental materials.

Abstract: A method and composition for remineralizing teeth wherein the composition contains a mixture of a casein glycomacropeptide and xylitol.

Abstract: A multicomponent anticaries dentifrice composition and method of use therefore, having a first dentifrice component containing a fluoride ion source and a second dentifrice component containing a casein glycomacropeptide compound, wherein the components are physically separated before use and are combined immediately prior to application to the teeth, the dentifrice exhibiting enhanced enamel remineralization.

Abstract: Stable oral compositions containing an antibacterial casein glycomacropeptide, an anionic surfactant, and a hydrolyzed protein stabilizer, which stabilizes the casein glycomacropeptide in the presence of the anionic surfactant against inactivation without substantially reducing its antibacterial properties.