Patents by Inventor Pradeep K. Dhal
Pradeep K. Dhal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8900560Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: GrantFiled: March 22, 2013Date of Patent: December 2, 2014Assignee: Genzyme CorporationInventors: Pradeep K. Dhal, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Vitaly Nivorozhkin, Bruce Shutts
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Patent number: 8889738Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: GrantFiled: March 12, 2012Date of Patent: November 18, 2014Assignee: Genzyme CorporationInventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
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Publication number: 20140322319Abstract: The present invention relates to crosslinked polyamine particles and/or pharmaceutical compositions comprising, at least in part, crosslinked polyamine particles and aggregates of such particles (including cured aggregates of crosslinked polyamine particles). The compositions may be in the form of tablets comprising, for example, particles larger than 500 ?m particles and used for treating patients, for example, patients with hyperphosphatemia.Type: ApplicationFiled: April 17, 2014Publication date: October 30, 2014Applicant: GENZYME CORPORATIONInventors: Stephen Randall Holmes-Farley, David J. HARRIS, Steven C. POLOMOSCANIK, Adnan SALAMEH, Bruce SHUTTS, Richard SILVA, Pradeep K. DHAL, Lynne SOLE
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Publication number: 20140235724Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: ApplicationFiled: April 24, 2014Publication date: August 21, 2014Applicant: GENZYME CORPORATIONInventors: Pradeep K. DHAL, David J. HARRIS, Stephen Randall HOLMES-FARLEY, Chad C. HUVAL, Vitaly NIVOROZHKIN, Bruce SHUTTS
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Publication number: 20130251667Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: ApplicationFiled: March 22, 2013Publication date: September 26, 2013Applicant: SANOFIInventors: Pradeep K. DHAL, David J. HARRIS, Stephen Randall HOLMES-FARLEY, Chad C. HUVAL, Vitaly NIVOROZHKIN, Bruce SHUTTS
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Patent number: 8425887Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: GrantFiled: September 26, 2007Date of Patent: April 23, 2013Assignee: Genzyme CorporationInventors: Pradeep K. Dhal, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Vitaly Nivorozhkin, Bruce Shutts
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Publication number: 20120288471Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.Type: ApplicationFiled: November 1, 2011Publication date: November 15, 2012Applicant: Genzyme CorporationInventors: Chad C. Huval, Stephen Randall Holmes-Farley, Pradeep K. Dhal
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Publication number: 20120237470Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: March 12, 2012Publication date: September 20, 2012Applicant: Genzyme CorporationInventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
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Patent number: 8163799Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: GrantFiled: December 10, 2007Date of Patent: April 24, 2012Assignee: Genzyme CorporationInventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
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Publication number: 20100266526Abstract: The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of a cholesterol-lowering agent. The first and second amounts together comprise a therapeutically effective amount. The invention further relates to pharmaceutical compositions useful for the treatment of hypercholesterolemia and atherosclerosis, and for reducing serum cholesterol. The pharmaceutical compositions comprise a combination of a first amount of an unsubstituted polydiallylamine polymer compound and a second amount of a cholesterol-lowering agent. The first and second amounts comprise a therapeutically effective amount. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutically acceptable carrier.Type: ApplicationFiled: November 9, 2009Publication date: October 21, 2010Applicant: Genzyme CorporationInventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal
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Publication number: 20100254935Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.Type: ApplicationFiled: February 19, 2010Publication date: October 7, 2010Applicant: Genzyme CorporationInventors: Chad C. Huval, Stephen Randall Holmes-Farley, Pradeep K. Dhal
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Publication number: 20100234309Abstract: Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: August 31, 2007Publication date: September 16, 2010Applicant: Genzyme CorporationInventors: Christopher Cooper, Pradeep K. Dhal, Rayomand H. Gimi, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Edward Lee
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Publication number: 20100196305Abstract: Sulfone-containing copolymers and copolymer networks and compositions including sulfone-containing copolymers and copolymer networks may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, sulfone-containing copolymers and copolymer networks may be derived from a multi-amine monomer and a multifunctional sulfonyl-containing monomer comprising two or more amine-reactive groups.Type: ApplicationFiled: March 5, 2008Publication date: August 5, 2010Inventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval, Steven C. Polomoscanik
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Publication number: 20100166696Abstract: Amide compounds, amide polymers and compositions, including amide compounds and amide polymers, may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, the amide polymers may be amido-amine dendrimers that may be formed via a series of iterative reactions.Type: ApplicationFiled: April 25, 2008Publication date: July 1, 2010Inventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval, Steven C. Polomoscanik
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Publication number: 20100129309Abstract: A pharmaceutical composition for treating hyperphosphatemia can include polymers derived from multi-amine monomers and multifunctional monomers, where the multifunctional monomer includes more than one electrophilic group.Type: ApplicationFiled: February 20, 2008Publication date: May 27, 2010Inventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval, Steven C. Polomoscanik
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Publication number: 20100124542Abstract: Ion binding compounds and compositions may include compounds, polymers and compositions that include amine moieties. Ion binding polymers may be crosslinked amine polymers and may be used to remove ions, such as phosphate ions, from the gastrointestinal tract of animals, such as humans. Such compounds, polymers and compositions may be used therapeutically to treat a variety of medical conditions, such as hyperphosphatemia.Type: ApplicationFiled: July 16, 2007Publication date: May 20, 2010Applicant: Genzyme CorporationInventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
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Publication number: 20100093857Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: December 10, 2007Publication date: April 15, 2010Applicant: Genzyme CorporationInventors: Pradeep K. Dhal, Stephen Randall Holmes-Farley, Chad C. Huval
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Publication number: 20100069500Abstract: Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.Type: ApplicationFiled: September 26, 2007Publication date: March 18, 2010Applicant: GENZYME CORPORATIONInventors: Pradeep K. Dhal, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Vitaly Nivorozhkin, Bruce Shutts
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Patent number: 7638524Abstract: The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of a cholesterol-lowering agent. The first and second amounts together comprise a therapeutically effective amount. The invention further relates to pharmaceutical compositions useful for the treatment of hypercholesterolemia and atherosclerosis, and for reducing serum cholesterol. The pharmaceutical compositions comprise a combination of a first amount of an unsubstituted polydiallylamine polymer compound and a second amount of a cholesterol-lowering agent. The first and second amounts comprise a therapeutically effective amount. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutically acceptable carrier.Type: GrantFiled: December 19, 2001Date of Patent: December 29, 2009Assignee: Genzyme CorporationInventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal
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Publication number: 20090162314Abstract: A pharmaceutical composition comprising an aliphatic amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable magnesium compound comprising a magnesium ion is disclosed. A method of treating hyperphosphatemia in a patient is also disclosed. The method comprises the step of administering to the subject an effective amount of the disclosed pharmaceutical composition.Type: ApplicationFiled: November 7, 2006Publication date: June 25, 2009Inventors: Chad C. Huval, Pradeep K. Dhal, Stephen Randall Holmes-Farley