Patents by Inventor Pradeep K. Dhal
Pradeep K. Dhal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090155368Abstract: The present invention relates to crosslinked polyamine particles and/or pharmaceutical compositions comprising, at least in part, crosslinked polyamine particles and aggregates of such particles (including cured aggregates of crosslinked polyamine particles). The compositions may be in the form of tablets comprising, for example, particles larger than 500 ?m, and used for treating patients, for example, patients with hyperphosphatemia.Type: ApplicationFiled: December 12, 2008Publication date: June 18, 2009Applicant: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, David J. Harris, Steven C. Polomoscanik, Adnan Salameh, Bruce Shutts, Richard Silva, Pradeep K. Dhal, Lynne Sole
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Publication number: 20090047233Abstract: Polymers and compositions utilizing such polymers are disclosed for treating hyperphosphatemia and other illnesses associated with elevated serum phosphate levels. Phosphate binding polymers, or a pharmaceutically acceptable salt of the polymers, comprise pendent groups extending from a backbone of the polymer. Each pendent group comprises at least two nitrogen-bearing functional groups which bind phosphate. Variations of such polymer and compositions are disclosed.Type: ApplicationFiled: August 25, 2006Publication date: February 19, 2009Inventors: Chad C. Huval, Stephen Randall Holmes-Farley, Pradeep K. Dhal
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Patent number: 7456156Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z? are independently —O—, —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5.Type: GrantFiled: January 31, 2006Date of Patent: November 25, 2008Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, Harry W. Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
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Patent number: 7125547Abstract: The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3–C24-alkyl group, an aralkyl group or an aryl group.Type: GrantFiled: August 25, 2003Date of Patent: October 24, 2006Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, Pradeep K. Dhal, John S. Petersen
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Patent number: 7049304Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z? are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol, ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5.Type: GrantFiled: December 30, 2004Date of Patent: May 23, 2006Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
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Patent number: 7041280Abstract: Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid. Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.Type: GrantFiled: June 27, 2002Date of Patent: May 9, 2006Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li, Steven Craig Polomoscanik
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Patent number: 6858592Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aryl group. Z and Z? are independently —O—. —NH— or —S—. X is an electron withdrawing group. R is a substituted or unsubstituted straight chained hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups and Y is —H, an amine, —[NH—(CH2)q]r—NH2, halogen, —CF3, thiol ammonium, alcohol, —COOH, —SO3H, —OSO3H or phosphonium group covalently bonded to the terminal position of R. Each —NH— in —[NH—(CH2)q]r—NH2 is optionally N-alkylated or N,N-dialkylated and —NH2 in —[NH—(CH2)q]r—NH2 is optionally N-alkylated, N,N-dialkylated or N,N,N-trialkylated. q is an integer from 2 to about 10 and r is an integer from 1 to about 5.Type: GrantFiled: June 27, 2002Date of Patent: February 22, 2005Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
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Publication number: 20040151687Abstract: The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.Type: ApplicationFiled: August 25, 2003Publication date: August 5, 2004Applicant: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, Pradeep K. Dhal, John S. Petersen
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Patent number: 6610283Abstract: The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.Type: GrantFiled: April 5, 1999Date of Patent: August 26, 2003Assignee: Genzyme CorporationInventors: Stephen Randall Holmes-Farley, Pradeep K. Dhal, John S. Petersen
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Publication number: 20030157414Abstract: A holographic recording medium showing little or no shrinkage after exposure comprises an acid generator capable of producing an acid upon exposure to actinic radiation; a binder; a difunctional epoxide monomer or oligomer; and a polyfunctional (i.e., tri- or higher functional) epoxide monomer or oligomer, the difunctional and polyfunctional epoxide monomers or oligomers being capable of undergoing cationic polymerization initiated by the acid produced from the acid generator. The medium is especially useful for holographic data storage applications.Type: ApplicationFiled: November 13, 1997Publication date: August 21, 2003Inventors: PRADEEP K. DHAL, RICHARD T. INGWALL, ERIC S. KOLB, HSIN YU LI, DAVID A. WALDMAN
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Patent number: 6565895Abstract: The invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a method of treating oral mucositis comprising administering an effective amount of a pharmaceutically acceptable bismuth-containing compound, such as a bismuth salt or bismuth complex. In a preferred embodiment, the bismuth compound is an organic or inorganic salt such as, bismuth subsalicylate, bismuth subgallate, bismuth aluminate, bismuth citrate, bismuth subcitrate, bismuth carbonate, bismuth subcarbonate, tripotassium dicitrato bismuthate, bismuth nitrate, bismuth subnitrate, bismuth tartrate and mixtures thereof, preferably, bismuth subsalicylate and bismuth subgallate.Type: GrantFiled: June 8, 2001Date of Patent: May 20, 2003Assignee: GelTex Pharmaceuticals, Inc.Inventors: Philip J. Goddard, Jeffrey D. Klinger, Pradeep K. Dhal, W. Harry Mandeville, III, Richard J. Fitzpatrick, Thomas X. Neenan
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Publication number: 20030064963Abstract: Disclosed is a phenyl boronic acid compound represented by Structural Formula (I): 1Type: ApplicationFiled: June 27, 2002Publication date: April 3, 2003Applicant: GelTex Pharmaceuticals, Inc.Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li
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Publication number: 20030059399Abstract: Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups.Type: ApplicationFiled: June 27, 2002Publication date: March 27, 2003Applicant: GelTex Pharmaceuticals, Inc.Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, Pradeep K. Dhal, Chad Cori Huval, Xinhua Li, Steven Craig Polomoscanik
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Patent number: 6489065Abstract: A holographic recording medium comprises (a) an acid generator capable of generating an acid upon exposure to actinic radiation; and (b) a polymer comprising a plurality of high refractive index moieties, a plurality of low refractive index moieties, and a plurality of acid-sensitive linking groups connecting the high and low refractive index moieties. When an interference pattern is formed within this medium, in the light areas of this interference pattern acid is generated by the acid generator and cleaves the acid-sensitive linking groups, thereby causing separation of either the high or the low refractive index moieties from the polymer, and formation of a hologram within the medium.Type: GrantFiled: May 17, 1996Date of Patent: December 3, 2002Assignee: Polaroid CorporationInventors: Pradeep K. Dhal, Eric S. Kolb, Richard A. Minns
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Publication number: 20020155091Abstract: The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of a cholesterol-lowering agent. The first and second amounts together comprise a therapeutically effective amount.Type: ApplicationFiled: December 19, 2001Publication date: October 24, 2002Applicant: GelTex Pharmaceuticals, Inc.Inventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal
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Patent number: 6365186Abstract: The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of a cholesterol-lowering agent. The first and second amounts together comprise a therapeutically effective amount. The invention further relates to pharmaceutical compositions useful for the treatment of hypercholesterolemia and atherosclerosis, and for reducing serum cholesterol. The pharmaceutical compositions comprise a combination of a first amount of an unsubstituted polydiallylamine polymer compound and a second amount of a cholesterol-lowering agent. The first and second amounts comprise a therapeutically effective amount. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutically acceptable carrier.Type: GrantFiled: May 13, 1999Date of Patent: April 2, 2002Assignee: GelTex Pharmaceuticals, Inc.Inventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal
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Patent number: 6294163Abstract: The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a guanidinium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise guanidinium moieties and optionally, additional substituents such as a hydrophobic group, a quaternary ammonium-containing group or a combination thereof.Type: GrantFiled: October 2, 1998Date of Patent: September 25, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Pradeep K. Dhal, Stephen R. Holmes-Farley, John S. Petersen
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Patent number: 6271264Abstract: The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise spirobicyclic ammonium moieties and optionally, further comprise a hydrophobic substituent, a quaternary ammonium-containing substituent or a combination thereof.Type: GrantFiled: December 1, 1998Date of Patent: August 7, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Pradeep K. Dhal, Steven C. Polomoscanik
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Patent number: 6264938Abstract: The invention relates to methods for treating hypercholesterolemia and atherosclerosis, and reducing serum cholesterol in a mammal. The methods of the invention comprise administering to a mammal a first amount of a bile acid sequestrant compound which is an unsubstituted polydiallylamine polymer and a second amount of an HMG Co-A reductase inhibitor compound. The first and second amounts together comprise a therapeutically effective amount. The invention further relates to pharmaceutical compositions useful for the treatment of hypercholesterolemia and atherosclerosis, and for reducing serum cholesterol. The pharmaceutical compositions comprise a combination of a first amount of an unsubstituted polydiallylamine polymer compound and a second amount of an HMG Co-A reductase inhibitor compound. The first and second amounts comprise a therapeutically effective amount. The pharmaceutical compositions of the present invention may optionally contain a pharmaceutically acceptable carrier.Type: GrantFiled: May 13, 1999Date of Patent: July 24, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal
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Patent number: 6248318Abstract: A method for treating hypercholesterolemia in a patient that includes administering to the patient a therapeutically effective amount of a polydiallylamine polymer.Type: GrantFiled: March 9, 2000Date of Patent: June 19, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Chad Cori Huval, Stephen Randall Holmes-Farley, John S. Petersen, Pradeep K. Dhal