Abstract: Provided are compositions and methods for lowering plasma LDL-C, increasing plasma HDL-C, and reducing atherosclerosis. The methods include administering to an individual in need miRNA-541-3P or a modified version thereof, or an agent other than the miRNA-541-3P or the modified version thereof that inhibits the function or expression of ZNF101 or CASZ1, or a combination thereof. Performing a method also decreases expression of apoB increases expression of apoA1 is increased.

Abstract: Techniques for using Locator ID Separation Protocol (LISP), Mobile Internet Protocol (MIP), and/or other techniques in conjunction with Domain Name System (DNS) to obfuscate server-side addresses in data communications. Rather than having DNS provide a client device with an IP address of an endpoint device, such as a server, the DNS instead returns an endpoint identifiers (EID) that is mapped to the client device and at least one routing locator (RLOC) of the endpoint device. In this way, IP addresses of servers are obfuscated by a network mapping of EIDs and RLOCs. The client device may then communicate data packets to the server using the EIDs as the destination address, and a virtual network service that works in conjunction with DNS can encapsulate the data packet with the RLOC using LISP and forward the data packet onto the server.

Abstract: In an example implementation consistent with the features disclosed herein, a tenant service in an internal network is made accessible to clients in an external network through a load balancer service. A request is transmitted by a tenant computing cluster in response to discovering creation of the tenant service at the tenant computing cluster. The request is received by a gateway computing cluster. The load balancer service is deployed at the gateway computing cluster in response to receiving the request. An external IP address for the external network is assigned to the load balancer service. The load balancer service is configured to forward client requests received at the external IP address to the tenant service. The external IP address is then sent to the tenant computing cluster.

Abstract: A system, method, and computer-readable storage medium, of which the method includes receiving an image of a tool including a consumable object from a remote device via a network at a processor, decoding the image to identify the consumable object, using the processor, and determining a degradation characteristic, a consumption, or both for the consumable object by providing the decoded image to a neural network. The degradation characteristic represents a mode of degradation and the consumption represents an amount of degradation.

Abstract: Techniques for automating traffic optimizations for egress traffic of an application orchestration system that is being sent over a network to a remote service. In examples, the techniques may include receiving, at a controller of the network, an egress traffic definition associated with egress traffic of an application hosted on the application orchestration system, the egress traffic definition indicating that the egress traffic is to be sent to the remote service. Based at least in part on the egress traffic definition, the controller may determine a networking path through the network or outside of the network that is optimized for sending the egress traffic to the remote service. The controller may also cause the egress traffic to be sent to the remote service via the optimized networking path.

Abstract: A wellness measurement method for measuring a level of wellness of an individual based on wellness function using a wellness measurement system is disclosed. The method includes steps of: measuring an approximation of the wellness function for computing the level of wellness of the individual based on microbiome data of the individual; determining wellness areas using symptom classes and corresponding diseases associated with symptoms based on the approximation of the wellness function; determining possible wellness gain using the maximization technique by assigning weightage to the determined wellness areas and a microbiome-wellness association network, and predicting an optimal value of microbiome configuration for the individual based on the wellness areas and the microbiome-wellness association network, being assigned with weightage; and outputting recommendations with the wellness gain through a plurality of constraints using a convex optimization.

Abstract: An example operation may include one or more of receiving, via a user interface, a feature set, querying a repository of application programming interfaces (APIs) to identify an API in the repository that corresponds to the received feature set based on a comparison of features in the feature set to features of the API stored in the repository, identifying criteria of the identified API that is published in the repository, and displaying a recommendation with the identified API including the identified criteria of the identified API via the user interface.

Abstract: The present invention relates to injectable pharmaceutical compositions comprising therapeutically effective amount of succinylcholine chloride, one or more pharmaceutically acceptable aqueous solvents, and one or more stabilizing agents selected from aliphatic polyols; lower alkyl alcohols; amino acids having at least one additional amino, carboxyl or hydroxyl group; amino alcohols; and aliphatic dicarboxylic acids having at least one hydroxyl or amino group, or ?-? unsaturation. The compositions are stable at room temperature for at least 30 days. Methods of manufacturing the injectable pharmaceutical compositions are also provided. The composition may be provided in a sealed container, e.g., an ampoule, vial and pre-filled syringe, and are suitable for subcutaneous, intravenous or intramuscular administration as an adjunct to general anesthesia, to facilitate tracheal intubation, and/or to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Abstract: A method for setting cooling parameters for a refrigerated transport vehicle includes receiving, from the transport vehicle, first information including energy consumption and performance parameters associated with the transport vehicle, and second information including vehicle type information and transit information associated with the transport vehicle. The method further includes retrieving historical data associated with peer transport vehicles similar to the transport vehicle based on the second information and identifying a peer transport vehicle for which energy and fuel consumption is minimum based on the second information and the retrieved historical data.

Abstract: In some embodiments, a method receives a definition that associates a compiler with a content type. The definition defines blocks that can be included in the content type. The method receives an input to create the content type on a platform. A compiler is selected from a plurality of compilers based on the compiler being associated with the content type in the definition. Compilers use different technologies to generate content, and the platform allows the plurality of compilers to be used. The method receives a model for creating content for the content type and processes the model using the compiler to create output for blocks in the model. The output for the blocks is rendered to display the content on a user interface.

Abstract: A system includes persistent storage containing predefined user interface (UI) component templates and a representation of a web page that includes a runtime UI component configured to reserve an empty portion of the web page to be populated by UI components generated at runtime. The system also includes a processor configured to perform operations, including receiving, from a client device, a request for the web page, and determining, based on the request, that the web page includes the runtime UI component. The operations also include determining runtime parameter values associated with the request, and determining, based on the runtime parameter values and the predefined UI component templates, context-specific UI components to populate the empty portion of the web page. The operations further include generating a context-specific representation of the web page based on the context-specific UI components, and transmitting, to the client device, the context-specific representation.

Abstract: One embodiment of the present invention sets forth a technique for performing 3D shape generation. This technique includes generating semantic features associated with an input sketch. The technique also includes generating, using a generative machine learning model, a plurality of predicted shape embeddings from a set of fully masked shape embeddings based on the semantic features associated with the input sketch. The technique further includes converting the predicted shape embeddings into one or more 3D shapes. The input sketch may be a casual doodle, a professional illustration, or a 2D CAD software rendering. Each of the one or more 3D shapes may be a voxel representation, an implicit representation, or a 3D CAD software representation.

Abstract: A network system includes a non-transitory computer readable medium configured to store instructions thereon; and a processor. The processor is configured to execute the instructions for providing a first information element in a protocol, wherein the first information element is usable to configure parameters associated with convergence of packet data; providing a second information element within the first information element, wherein the second information element is usable for a first range of logical channels; and providing a third information element within the first information element, wherein the third information element is usable for a second range of logical channels outside of the first range of logical channels.

Abstract: A system, method, and apparatus can access, via a user interface, route properties of a mine site used for controlling one or more work machines as the work machine(s) travel through the mine site. Access regarding the route properties can include viewing one or more of the properties and/or setting requirements (e.g., restrictions or limitations) for one or more of the properties. A candidate route can be selected, validated, and set as a selected route using the user interface to access route properties associated with the selected route. Requirements can be set for one or more of the route properties using the user interface. The work machines can be controlled to traverse the mine site according to the requirements set for the route properties.

Abstract: An Open Radio Access Network (O-RAN) communication system includes a GNB Central Unit Control Plane (GNB-CUCP) to establish a connection with a Near-RT RIC via an E2 interface; a User Equipment (UE); a plurality of cells in a Tracking Area (TA) of the GNB-CUCP; and an O-RAN Near-Real Time (Near-RT) RAN Intelligent Controller (RIC) to host an xApp and initiate a subscription procedure with the UE. The GNB-CUCP sends cell location information of the UE to the Near-RT RIC upon a UE context release procedure, the Near-RT RIC creates and maintains a record of the cell location information received from the GNB-CUCP via the xApp, and the GNB-CUCP pages the UE in a subset of cells from the plurality of cells in the TA, the subset of cells corresponding to the record of cell location information created and maintained by via the xApp.

Abstract: A method for implementing dynamic content handling of inter layer messages in a pod based cloud native environment, the method includes: receiving, by a virtual centralized unit (vCU), at least one Master Information Block (MIB) parameter configured by a virtual element management system (vEMS); preparing, by the vCU, a MIB encoded buffer may include a Dummy System Frame Number (D-SFN); sending, by the vCU, once at the time of startup initiation, the MIB encoded buffer with the D-SFN to a virtual distributed unit (vDU) via a Midhaul between the vCU and the vDU; receiving, by the vDU, the MIB encoded buffer with the D-SFN via the Midhaul; for each received MIB encoded buffer, by the vDU, calculating a new SFN from an utility function; updating the MIB encoded buffer; and sending the updated MIB encoded buffer with the new SFN from the utility function to a user entity (UE).

Abstract: According to one aspect of an exemplary embodiment of the disclosure, a mammography imaging system or device includes a brassiere including one or more inflation chambers to assist in automatically positioning the breast. The brassiere includes cup in which the breast is positioned that includes a radiolucent cushion material along with the chambers and one or more inflatable chambers to compress/push the breast forward to position the breast within the cup as desired. In addition, the brassiere includes a vacuum system secured to the front part of the cup to pull the tip or nipple portion of the breast forward with vacuum-based suction technique. With the initial compression of the breast within the cup, the compression paddle of the imaging system can then be employed to apply any necessary additional force across the breast to achieve the required breast position and thickness for the selected image view, with the cushion material limiting any discomfort from the compression.

Abstract: The present disclosure relates to pharmaceutical salts and polymorphic forms of pyrimidine derivatives that have inhibitory activities against mutant epidermal growth factor receptor (EGFR). The present disclosure further relates to the processes for the preparation of the pyrimidine derivatives and to the pharmaceutical salts and the polymorphic forms of the pyrimidine derivatives.

Abstract: A method for operating an underground loader is disclosed. The method includes detecting, by a controller, a first position of the underground loader within a worksite. The method also includes determining, by the controller, a location of a dumping pit within the worksite. Further, the method includes determining, by the controller, a route for the underground loader to tram from the first position to the location of the dumping pit. Furthermore, the method includes controlling, by the controller, a movement of the underground loader along the route up to the location of the dumping pit. The method also includes moving, by the controller, an implement assembly of the underground loader based on a profile of a terrain along the route and a height of an embankment defined at an edge of the dumping pit.