Abstract: The present disclosure is related to STING agonists, linker-payloads thereof, and conjugates thereof, pharmaceutical compositions thereof, and the use of the agonists, conjugates, and pharmaceutical compositions to induce a STING-mediated immune response and/or for the treatment of diseases and disorders mediated by STING.

Abstract: Stable pharmaceutical compositions are provided, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: A lead zirconate-based antiferroelectric material is provided that includes lithium and bismuth substitutions for lead on the perovskite crystal structure. The lithium and bismuth are provided at an atomic ratio of 1:1, and the lead may substituted with lithium and bismuth up to 16 at %. The modified composition provides increased energy efficiency, increased dielectric breakdown strength, and lower sintering temperature. The modified composition is suitable for use as a capacitor having high power density and energy density.

Abstract: Stable pharmaceutical compositions are provided, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: Processes and apparatus for low-CO2 emissions methanol production using a high efficiency (>90%) reformer fired with a low-carbon fuel (C:H<0.03) to produce syngas. CO2 is removed from the syngas, and the CO2-lean syngas is fed to a methanol synthesis loop. A purge stream from the methanol synthesis loop is processed to recover a hydrogen-rich stream and a tail gas stream. The hydrogen-rich stream is supplied as fuel to fire the reformer, along with a portion (<10%) of the tail gas, to produce a CO2-lean flue gas (<3 vol %, dry basis). The flue gas is optionally cooled below a dew point to form condensate, which can be collected and removed. The methanol production can have a carbon efficiency of 97% or more, and a CO2 emissions reduction (compared to natural gas firing) of 88% or more.

Abstract: Systems, methods, and devices for encoding and decoding a packet buffer for data exchange over a communications network, including parsing a data container definition file to determine a packet format; generating a code file based on the data container definition file; inserting the code file into a source tree of an application; compiling the source tree to generate an executable file; and executing the executable on a computing device in communication with the communications network, wherein the executable file encodes and decodes the packet buffer for data exchange over the communications network.

Abstract: This disclosure is directed to methods, computer program products, and systems for providing surface vehicle tracking data, including indications of potential collision zones, to an airport map display system onboard an aircraft. In one example, a method includes identifying historical navigation route data, aerodrome guidance features, and a predicted path of a first vehicle. The method further includes determining predicted positions along the predicted path and determining predicted positions of a second vehicle and comparing vehicle envelopes for the two vehicles to determine a predicted collision zone of the vehicles.

Abstract: Various embodiments herein each include at least one of systems, methods, and software for value transfer between disparate systems. One such embodiment includes receiving a transfer request to transfer a value from a first account provider to an account maintained with a second account provider and including data identifying an individual or entity that initiated the transfer request. This method also includes identifying the second account provider based on data included in the transfer request and generating a request to transfer the value of the transfer request to the account in a format compatible with the second account provider. The method may then transmit the generated request to the second account provider.

Abstract: Stable pharmaceutical compositions are provided, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: Various embodiments herein each include at least one of systems, methods, and software for value transfer between disparate systems. One such embodiment includes receiving a transfer request to transfer a value from a first account provider to an account maintained with a second account provider and including data identifying an individual or entity that initiated the transfer request. This method also includes identifying the second account provider based on data included in the transfer request and generating a request to transfer the value of the transfer request to the account in a format compatible with the second account provider. The method may then transmit the generated request to the second account provider.

Abstract: The present invention provides stable pharmaceutical compositions, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions, as well as methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: An apparatus and computerized method of tracking a usage of an exercise equipment includes providing a sensor operably connected to the exercise equipment, wherein the sensor is in a low power state, automatically exiting the low power state whenever a change in the exercise equipment is detected by the sensor, automatically capturing a usage event associated with the exercise equipment, automatically transmitting a set of data associated with the usage event to a collection application programming interface (API) on a server, automatically entering the low power state of the sensor, storing the set of data associated with the usage event in a database communicably coupled to the server, determining a usage data for the exercise equipment based on the set of data associated with two or more usage events using the server, and transmitting the usage data to one or more remote devices communicably coupled to the server or the database.

Abstract: The present invention provides stable pharmaceutical compositions, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions, as well as methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: The present invention provides stable pharmaceutical compositions, comprising a pharmaceutically effective amount of testosterone or a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable oil vehicle, and a stabilizing amount of benzyl alcohol, for example, about 1% to 3% weight/volume of benzyl alcohol. The present invention also provides a process for stabilizing testosterone-containing pharmaceutical compositions by ageing them at a temperature of about 20° C. to about 60° C. for at least 48 hours, e.g., prior to secondary packing and labeling. These compositions were stable over the shelf life of the product, without exhibiting crystal formation, even upon storing at temperatures of about 2° C. to about 8° C. Other aspects of the invention relate to methods for making such pharmaceutical compositions, and methods of using such pharmaceutical compositions for hormone replacement therapy, e.g.

Abstract: A system generating virtual reality spatial representation of functional spaces and a method for using the same is disclosed. The system comprises of a remote server executing a plurality of instructions to generate a three dimensional spatial representation of functional spaces upon receiving an input such as a floor plan from the user of the system. The spatial representation thus created is rendered in virtual or mixed reality and allows the user to interact with the representation. In addition, the system of the present disclosure allows the user to collaborate with one or more other users to add a plurality of virtual objects into the spatial representation and use the annotated representation for designing functional spaces. Other methods are also described herein.

Abstract: This disclosure is directed to methods, computer program products, and systems for providing surface vehicle tracking data, including indications of potential collision zones, to an airport map display system onboard an aircraft. In one example, a method includes identifying historical navigation route data, aerodrome guidance features, and a predicted path of a first vehicle. The method further includes determining predicted positions along the predicted path and determining predicted positions of a second vehicle and comparing vehicle envelopes for the two vehicles to determine a predicted collision zone of the vehicles.

Abstract: A Virtual Cloud Exchange (VCX) and method for establishing connectivity between a host computer in a customer network and a cloud service provider, includes a customer facing software defined network (SDN) switch; a cloud computing service facing SDN switch; and a processor executing instructions to generate a customer facing network routing virtual network function (VNF) and a cloud facing network routing VNF; and configure a first open virtual switch (vSwitch) and a second open vSwitch. The customer facing SDN switch generates a first overlay tunnel between the customer facing SDN switch and the first open vSwitch and the cloud facing SDN switch generates a second overlay tunnel between the cloud facing SDN switch and the second open vSwitch.

Abstract: Systems and techniques for delivery of contextual interest from interaction information are described that process user interactions with digital content to generate user interest scores for various topics. A contextual user interest system uses user interaction data to identify and contextualize content, and assigns propensity scores to the contextualized content. By dynamically contextualizing pages of content, the contextual user interest system may adapt to changes in the content and provide more accurate and robust information over time, which is not possible using conventional techniques. The contextualized pages of content are used to assign user interest scores across a number of topics to users who have visited the pages of content, and the user interest scores are normalized in a manner that allows a user's degree of interest in a topic to be compared to that of another user.

Abstract: A method involves a headless IoT device wirelessly communicating a MAC address to a client device in response to a scan by the client device, and receiving from the client device a vendor action frame comprising access credentials for communicating via a Wi-Fi access point. The IoT device applies the credentials to authenticate to the Wi-Fi access point, forms an application layer for communicating over the Wi-Fi access point network, and communicates with the client device via the application layer.

Abstract: A system generating virtual reality spatial representation of functional spaces and a method for using the same is disclosed. The system comprises of a remote server executing a plurality of instructions to generate a three dimensional spatial representation of functional spaces upon receiving an input such as a floor plan from the user of the system. The spatial representation thus created is rendered in virtual or mixed reality and allows the user to interact with the representation. In addition, the system of the present disclosure allows the user to collaborate with one or more other users to add a plurality of virtual objects into the spatial representation and use the annotated representation for designing functional spaces. Other methods are also described herein.