Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: Epidermal electronics are non-invasive and non-obstructive skin mounted sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate.

Abstract: Epidermal electronics are non-invasive and non-obstructive skin mounted sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate.

Abstract: Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.

Abstract: Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The present specification provides a two-dimensional code identification method and device, and a two-dimensional code positioning and identification model establishment method and device. The two-dimensional code identification method includes: obtaining a to-be-identified two-dimensional code, and performing global feature positioning detection on the to-be-identified two-dimensional code by using a pre-established two-dimensional code positioning and identification model; performing focus adjustment, based on a predetermined image resolution, on the to-be-identified two-dimensional code on which positioning detection is performed; and decoding the to-be-identified two-dimensional code on which focus adjustment is performed. The present specification can improve the identification accuracy of two-dimensional codes shot in complex scenarios.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The disclosure discloses a video enhancement method and device, and belongs to the field of image processing. The method includes that: each frame in a video is sequentially acquired; and for each current frame, attribute information reflecting a moving state or luminance is determined, a preset mapping relationship is searched to obtain a control parameter corresponding to the attribute information, and video enhancement operation is executed on the current frame by using the control parameter. The device includes: an acquisition module and an enhancement module. By the disclosure, the problem of processing inflexibility caused by execution of the same enhancement over each frame in the video is solved, each frame in the video may be differentially enhanced, frame-based video enhancement is implemented, a video enhancement effect is effectively improved, and quality of the video is improved.

Abstract: The present specification provides a two-dimensional code identification method and device, and a two-dimensional code positioning and identification model establishment method and device. The two-dimensional code identification method includes: obtaining a to-be-identified two-dimensional code, and performing global feature positioning detection on the to-be-identified two-dimensional code by using a pre-established two-dimensional code positioning and identification model; performing focus adjustment, based on a predetermined image resolution, on the to-be-identified two-dimensional code on which positioning detection is performed; and decoding the to-be-identified two-dimensional code on which focus adjustment is performed. The present specification can improve the identification accuracy of two-dimensional codes shot in complex scenarios.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The present specification provides a two-dimensional code identification method and device, and a two-dimensional code positioning and identification model establishment method and device. The two-dimensional code identification method includes: obtaining a to-be-identified two-dimensional code, and performing global feature positioning detection on the to-be-identified two-dimensional code by using a pre-established two-dimensional code positioning and identification model; performing focus adjustment, based on a predetermined image resolution, on the to-be-identified two-dimensional code on which positioning detection is performed; and decoding the to-be-identified two-dimensional code on which focus adjustment is performed. The present specification can improve the identification accuracy of two-dimensional codes shot in complex scenarios.

Abstract: The present specification provides a two-dimensional code identification method and device, and a two-dimensional code positioning and identification model establishment method and device. The two-dimensional code identification method includes: obtaining a to-be-identified two-dimensional code, and performing global feature positioning detection on the to-be-identified two-dimensional code by using a pre-established two-dimensional code positioning and identification model; performing focus adjustment, based on a predetermined image resolution, on the to-be-identified two-dimensional code on which positioning detection is performed; and decoding the to-be-identified two-dimensional code on which focus adjustment is performed. The present specification can improve the identification accuracy of two-dimensional codes shot in complex scenarios.

Abstract: An electronic door opening/closing apparatus and an electronic door opening/closing detection method, apparatus, and device are disclosed. The electronic door opening/closing apparatus includes: an electronic lock, disposed at a side-hinged door and configured to limit a turn of a door panel of the side-hinged door when the electronic lock is locked; a turning detector, disposed at the side-hinged door and configured to detect a turning parameter of the door panel of the side-hinged door to generate a turning parameter signal; a position detector, disposed at the side-hinged door and configured to generate a door state signal based on a position-approaching condition; and a main controller, configured to determine an open or closed state of the side-hinged door. The turning parameter signal is combined with the door state signal to accurately determine the open or closed state of the side-hinged door, and to effectively prevent malicious lock deception.

Abstract: An electronic door opening/closing apparatus and an electronic door opening/closing detection method, apparatus, and device are disclosed. The electronic door opening/closing apparatus includes: an electronic lock, disposed at a side-hinged door and configured to limit a turn of a door panel of the side-hinged door when the electronic lock is locked; a turning detector, disposed at the side-hinged door and configured to detect a turning parameter of the door panel of the side-hinged door to generate a turning parameter signal; a position detector, disposed at the side-hinged door and configured to generate a door state signal based on a position-approaching condition; and a main controller, configured to determine an open or closed state of the side-hinged door. The turning parameter signal is combined with the door state signal to accurately determine the open or closed state of the side-hinged door, and to effectively prevent malicious lock deception.

Abstract: Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.

Abstract: A dual-mode epidermal sensor/electrode that, when worn on a human chest, is capable of synchronously/continuously monitoring electrical activity and mechano-acoustic activity of a cardiovascular system. The dual-mode epidermal sensor/electrode consists of a pair of stretchable electrocardiogram (ECG) electrodes made out of filamentary serpentine gold nano-membranes and a stretchable seismocardiogram (SCG) sensor comprising a filamentary serpentine PVDF. The dual-mode epidermal sensor/electrode is light, thin, flexible, and requires no operational power. The sensor can be laminated conformably and unobtrusively on a human chest to provide high fidelity ECG measurements and SCG measurements, and an estimated beat-to-beat blood pressure (BP). The dual-mode epidermal sensor is fabricated using a cost-effective, cut-and-paste method of construction.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: Epidermal electronics are sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate. Also, a stretchable planar coil made of serpentine ribbons can be used as a wireless strain gauge and/or a near field communication (NFC) antenna. Other embodiments are described herein.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.